bachelor's at Licenciatura em Ciências Biológicas from Universidade de São Paulo (2006), bachelor's at Ciencias Biologicas from Universidade de São Paulo (2004), master's at Imunologia from Depato. de Imunologia/Instituto de Ciências Biomédicas/USP (2007) and doctorate at Immunology from Universidade de São Paulo (2010). (Source: Lattes Curriculum)
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Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppressiv…
Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppressiv…
In infectious diseases, the enzyme indolemine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune regulation mediated by the Kyn-mediated expansion of regulatory T cells via Aryl hydrocarbon receptor (AhR). In pulmonary paracoccidioidomycosis…
Plasmacytoid dendritic cells (pDCs), considered critical for immunity against viruses, were recently associated with defense mechanisms against fungal infections. However, the immunomodulatory function of pDCs in pulmonary paracoccidiodomycosis (PCM), an endemic fungal infection of Latin America, has been poorly defined. Here, we investigated the role of pDCs in the pathogenesis of PCM ca…
Dendritic cells (DCs) constitute a link between the innate and adaptive immunity. According to the subclass and activation pattern they may play an important role in regulatory and protective immunological effects to the host. In paracoccidioidomycosis (PCM), the systemic mycosis with highest incidence in Latin America, the role of DCs has been poorly studied, although several lines of wo…
Granulomas are important immunological structures in host defense against the dimorphic fungal Paracoccidioides brasiliensis, the main causative agent of Paracoccidioidomycosis (PCM), a chronic systemic mycosis endemic in several Latin America countries. The interaction of P. brasiliensis with the host tissue initially triggers a congestive-exsudative inflammatory reaction, with a predomi…
In paracoccidioidomycosis, the most prevailing systemic mycosis in Latin America, previous studies revealed that the host's immunity is strongly dictated by a diversity of suppressing mechanisms mediated by plasmocytoid dendritic cells, by the 2,3 indoleamine dioxygenase enzyme (IDO1) and regulatory T cells. The activity of IDO1 was demonstrated when orchestrating local and systemic immun…
Granulomas are immunological structures important in the host defense against the thermally dimorphic fungus Paracoccidioides brasiliensis, the main agent causative of Paracoccidioidomycosis (PCM), a systemic chronic mycosis endemic several Latin America countries. The interaction of P. brasiliensis with host tissue initially triggers a congestive-exudative inflammatory reaction with a pr…
(Only some records are available in English at this moment)
A previous study on Paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that the host immunity is strongly regulated by several suppressor mechanisms mediated by plasmocytoid dendritic cells, by the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). The activity of IDO1 was demonstrated by orchestrating local and systemic immu…
Granulomas are immunological structures important in the host defense against the thermally dimorphic fungus Paracoccidioides brasiliensis, the main agent causative of Paracoccidioidomycosis (PCM), a systemic chronic mycosis endemic several Latin America countries. The interaction of P. brasiliensis with host tissue initially triggers a congestive-exudative inflammatory reaction with a pr…
(Only some records are available in English at this moment)
In preliminary studies Ramirez-Ortiz et al. 2011, demonstrate that plasmacytoid dendritic cells (pDCs) phagocytose Aspergillus fumigatus conidia and spread over the surface of the hyphal morphotype. In response to hyphal stimulation, pDCs directly inhibit fungal growth and release IFN-± and TNF-±. These studies together with this project challenge the prevailing dogma regarding the specia…
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 12 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 24 / 18 | All research grants and scholarships |
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CV Lattes
ORCID