Flávio Vieira Loures
CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Licenciatura em Ciências Biológicas from Universidade de São Paulo (2006), bachelor's at Ciencias Biologicas from Universidade de São Paulo (2004), master's at Imunologia from Depato. de Imunologia/Instituto de Ciências Biomédicas/USP (2007) and doctorate at Immunology from Universidade de São Paulo (2010). (Source: Lattes Curriculum)
- Multi-User Equipment approved in grant 2018/14762-3: flow cytometer FACS lyric, AP.EMU
Abstract
Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppress...
- Immunosuppression in paracoccidioidomycosis: the regulatory role of myeloid-derived suppressor cells (MDSCs) on host immunity, tissue pathology and genetic adaptation of fungal cells, AP.JP2
Abstract
Previous studies in paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppress...
- The IDO-AhR axis controls Th17/Treg immunity in a pulmonary model of fungal infection, PUB.ART
Abstract
In infectious diseases, the enzyme indolemine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune regulation mediated by the Kyn-mediated expansion of regulatory T cells via Aryl hydrocarbon receptor (AhR). In pulmonary paracoccidioidomycos...
- Tolerogenic plasmacytoid dendritic cells control Paracoccidioides brasiliensis infection by inducting regulatory T cells in an IDO-dependent manner, PUB.ART
Abstract
Plasmacytoid dendritic cells (pDCs), considered critical for immunity against viruses, were recently associated with defense mechanisms against fungal infections. However, the immunomodulatory function of pDCs in pulmonary paracoccidiodomycosis (PCM), an endemic fungal infection of Latin America, has been poorly defined. Here, we investigated the role of pDCs in the pathogenesis of PCM ...
- Study of the plasmacytoid and myeloid dendritic cells function during Paracoccidioides brasiliensis infection, AP.JP
Abstract
Dendritic cells (DCs) constitute a link between the innate and adaptive immunity. According to the subclass and activation pattern they may play an important role in regulatory and protective immunological effects to the host. In paracoccidioidomycosis (PCM), the systemic mycosis with highest incidence in Latin America, the role of DCs has been poorly studied, although several lines of ...
- The role of indoleamine 2, 3-dioxygenase 1 (IDO-1) in immunosuppressive mechanisms of myeloid-derived suppressor cells (MDSCs) in Pulmonary Paracoccidioidomycosis, BP.PD
Abstract
Previous studies in Paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that immunity of hosts is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 Indoleamine Dioxygenase (IDO1) and regulatory T cells (Treg). IDO1 was also seen to orchestrate local and systemic immunosuppress...
- Action of Liver-X receptor (LXR) agonists on the depletion of myeloid derived supressor cells (MDSCs) in murine pulmonary paracoccidioidomycosis, BP.IC
Abstract
A previous study on Paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that the host immunity is strongly regulated by several suppressor mechanisms mediated by plasmocytoid dendritic cells, by the enzyme 2,3 indoleamine dioxygenase (IDO1) and regulatory T cells (Treg). The activity of IDO1 was demonstrated by orchestrating local and systemic im...
- Bioinformatic analysis of transcriptional and proteomic profile of P. brasiliensis yeasts present in chronic granulomatous lesions of C57BL/6 WT mice, BP.TT
(Only some records are available in English at this moment)
- Function of interferons in murine pulmonary PCM: comparative evaluation of disease severity between control mice and knockouts for IFN-alpha/betaR, IFN-gammaR and IRF-1, BP.IC
Abstract
Dendritic cells (DCs) constitute a link between the innate and adaptive immunity. According to the subclass and activation pattern they may play an important role in regulatory and protective immunological effects to the host. In paracoccidioidomycosis (PCM), the systemic mycosis with highest incidence in Latin America, the role of DCs has been poorly studied, although several lines of ...
- Characterization of human pDCs in PCM: innate receptors expression and tolerance mechanisms, BP.IC
Abstract
Dendritic cells (DCs) constitute a link between the innate and adaptive immunity. According to the subclass and activation pattern they may play an important role in regulatory and protective immunological effects to the host. In paracoccidioidomycosis (PCM), the systemic mycosis with highest incidence in Latin America, the role of DCs has been poorly studied, although several lines of ...
- Type I interferons function in murine pulmonary PCM: comparative assessment of disease severity between control and knockout mice for IFN-aBR, BP.IC
Abstract
Dendritic cells (DCs) constitute a link between the innate and adaptive immunity. According to the subclass and activation pattern they may play an important role in regulatory and protective immunological effects to the host. In paracoccidioidomycosis (PCM), the systemic mycosis with highest incidence in Latin America, the role of DCs has been poorly studied, although several lines of ...
(Only some records are available in English at this moment)
- How does plasmacytoid dendritic cells contribute to host defenses against invasive aspergillosis?, BE.EP.PD
Abstract
In preliminary studies Ramirez-Ortiz et al. 2011, demonstrate that plasmacytoid dendritic cells (pDCs) phagocytose Aspergillus fumigatus conidia and spread over the surface of the hyphal morphotype. In response to hyphal stimulation, pDCs directly inhibit fungal growth and release IFN-± and TNF-±. These studies together with this project challenge the prevailing dogma regarding the spec...
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 9 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 21 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 6 |
| Citations | 41 |
| Cit./Article | 6.8 |
| Data from Web of Science | |
DE ARAUJO, ELISEU FRANK; MEDEIROS, DANIELLA HELENA; DE LIMA GALDINO, NAYANE ALVES; CONDINO-NETO, ANTONIO; GARCIA CALICH, VERA LUCIA; LOURES, FLAVIO VIEIRA. Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner. PLOS PATHOGENS, v. 12, n. 12, DEC 2016. Web of Science Citations: 10. (14/18668-0, 14/22630-9, 15/12328-6)
NUNES, BRUNO GHIROTTO; LOURES, FLAVIO VIEIRA; SIQUEIRA BUENO, HELOISA MARIA; CANGUSSU, ERICA BARONI; GOULART, ERNESTO; COATTI, GIULIANA CASTELLO; CALDINI, ELIA GARCIA; CONDINO-NETO, ANTONIO; ZATZ, MAYANA. Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. European Journal of Human Genetics, v. 25, n. 12, p. 1388-1396, DEC 2017. Web of Science Citations: 0. (15/19435-2, 13/08028-1, 14/04783-2)
PREITE, NYCOLAS WILLIAN; FERIOTTI, CLAUDIA; DE LIMA, DHEMERSON SOUZA; DA SILVA, BRUNO BORGES; CONDINO-NETO, ANTONIO; PONTILLO, ALESSANDRA; GARCIA CALICH, VERA LUCIA; LOURES, FLAVIO VIEIRA. The syk-coupled C-Type lectin receptors Dectin-2 and Dectin-3 are involved in Paracoccidioides brasiliensis recognition by human Plasmacytoid Dendritic cells. FRONTIERS IN IMMUNOLOGY, v. 9, MAR 20 2018. Web of Science Citations: 1. (17/00711-5, 13/02396-9, 16/23189-0, 14/04783-2)
DE CASTRO, PATRICIA ALVES; COLABARDINI, ANA CRISTINA; MANFIOLLI, ADRIANA OLIVEIRA; CHIARATTO, JESSICA; SILVA, LILIAN PEREIRA; MATTOS, ELICIANE CEVOLANI; PALMISANO, GIUSEPPE; ALMEIDA, FAUSTO; PERSINOTI, GABRIELA FELIX; ANNICK RIES, LAURE NICOLAS; et al. Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance. PLOS GENETICS, v. 15, n. 12, DEC 2019. Web of Science Citations: 0. (17/07536-4, 16/21392-2, 14/06863-3, 16/12948-7, 16/07870-9, 16/22062-6, 14/04783-2, 17/19288-5)
DE ARAUJO, ELISEU FRANK; FERIOTTI, CLAUDIA; DE LIMA GALDINO, NAYANE ALVES; PREITE, NYCOLAS WILLIAN; GARCIA CALICH, VERA LUCIA; LOURES, FLAVIO VIEIRA. The IDO-Ahr axis controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection. FRONTIERS IN IMMUNOLOGY, v. 8, JUL 24 2017. Web of Science Citations: 16. (11/51258-2, 14/04783-2)
ARAUJO, ELISEU F.; LOURES, FLAVIO V.; BAZAN, SILVIA B.; FERIOTTI, CLAUDIA; PINA, ADRIANA; SCHANOSKI, ALESSANDRA S.; COSTA, TANIA A.; CALICH, VERA L. G.. Indoleamine 2,3-Dioxygenase Controls Fungal Loads and Immunity in Paracoccidioidomicosis but is More Important to Susceptible than Resistant Hosts. PLoS Neglected Tropical Diseases, v. 8, n. 11, NOV 2014. Web of Science Citations: 14. (12/01765-8)
(References retrieved automatically from State of São Paulo Research Institutions)
LOURES, Flávio Vieira. O receptor de reconhecimento de patógenos TLR-2 e a proteína adaptadora MYD88 apresentam um importante papel na infecção murina contra o Paracoccidioides brasiliensis. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (06/61048-7)