Abstract
Proteglycans are macromecules composed by a specific core protein to witch linear chains of heteropolysaccharides, the glycosaminoglycans, are covalently linked. The proteglycans participate in many functions as angiogenesis, cellular differentiation and proliferation, adhesion, apoptosis, invasion and metastasis. MicroRNAs, small non-coding RNAs with 19 to 25 nucleotides, play critical r…