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Regina Pekelmann Markus


Universidade de São Paulo (USP). Instituto de Biociências (IB)  (Institutional affiliation from the last research proposal)
Birthplace: Brazil

Full Professor of the Institute of Biosciences at the University of São Paulo and Senior Researcher at CNPq. Member of the Academies of Sciences of the State of São Paulo (ACIESP, 1980) and Brazilian (ABC, 2012). Graduated in Biomedical Sciences from Escola Paulista de Medicina (1970) and Ph.D. in Pharmacology from the same institution in 1974. Full Professor in Pharmacology from USP (1989). Since the beginning of her career, she has been active in Scientific Societies and has been President of SBFTE (Brazilian Society of Experimental Pharmacology and Therapeutics) and member of FESBE and SBPC Board of Directors as General Secretary and Treasurer. She served on Advisory Committees of CAPES and CNPq, Deliberative Council CNPq and titular of the Secretariat for Research and Development Policies and Programs of MCTI (2003) and the National Council for Ethics in Research in Laboratory Animals. She is currently the president of the Evaluation Committee of Embrapii. Since 2007 he has served as Vice-President of the Friends Association of the Weizmann Institute, Brazil. She is a reviewer for several international journals and belongs to the Editorial Board of the Journal Pineal Research, Frontiers in Cellular Endocrinology and Brain Behavior and Immunity. She co-chaired the 3rd SCR FASEB on Melatonin Biology, Clinics and Therapeutics (2013, Niagara Falls, USA) and is a member of the International Union for Pharmacology Committee (IUPHAR) for melatonin receptors.Research line:Chronopharmacology with emphasis on the role of melatonin on the inflammatory responses is our main interest. We introduced the concept of an Immune-Pineal Axis, responsible for alternation between melatonin production by pineal or immunocompetent cells. Currently, we are collaborating in the development of new molecular platform of selective and mixed ligands of melatonin receptors focusing on cancer therapies, overweight and neurodegenerative diseases based on the concept of the Immune-Pineal Axis. The search for a theory that allows the integration of melatonin functions as a chronobiotic and an immunomodular agent, considering the different sources of melatonin, lead to the MEL-Index, a gene index that relates transcription of genes that code synthesis and degradation enzymes, in order to estimate the ability of a tissue to synthesize melatonin. These data applied to different tumors may serve as a prognostic index of their evolution. In collaboration with researchers at the Weizmann Institute of Israel Research in 2018, we demonstrated that mouse bone marrow is capable of synthesizing melatonin rhythmically, under the direct command of sympathetic nervous system and coupled to an endogenous TNF rhythm. Reevaluating the paradigm shift of the daily rhythm of bone and blood formation is the corollary of this line of research. The extra-pineal production of melatonin by resident macrophages, including alveolar macrophages, has been shown to be essential for protection against pollution and, also in inhibiting the expression of proteins that allow viruses, such as SARS-COV2. After 25 years of work, this line of research is now recognized in the literature. In 2018, the immune-pineal axis was considered an orchestrator of the defense response (PMID: 30917240). In addition, the immune-pineal axis concept is now being explored by authors who come to prove the relevance of an organization between pineal and extra-pineal production of melatonin, to provide an adequate defense response. Its deviations serve as a scenario for the development of pathologies based on silent inflammations. (Source: Lattes Curriculum)

Articles published in Pesquisa FAPESP Magazine about the researcher:
Desprotegido contra el Alzheimer 
Unprotected against Alzheimer’s 
Memorias de origen 
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