Antonio Cardozo dos Santos

• Abstract

  The clinical use of cisplatin (cis-diaminochloroplatin II) is limited by its severe adverse effects, including neurotoxicity. Platinum compounds accumulate in sensory neurons, causing loss of myelinated fibers, axonal degeneration, and neuronal dysfunction. The main clinical manifestation is peripheral sensory neuropathy characterized by loss of reflexes, paresthesia in the extremities of…

  Cisplatin-induced peripheral sensory neuropathy: Study of the mechanisms of neurotoxicity of cisplatin and neuroprotection of caffeic acid phenethyl ester (CAPE) in PC-12 cells, AP.R

• Abstract

  Organophosphate pesticides (OPs) are widely used in the chemical industry and agriculture worldwide. Many of them are potential causes of Organophosphate-induced delayed neuropathy (OPIDN), characterized by distal degeneration of axons of the central and peripheral nervous system (Wallerian-type degeneration). Our previous studies with OP have associated NRIOP with the increase in the int…

  Organophosphorus-induced delayed neuropathy: in vitro study of the mechanisms of neurotoxicity of trichlorfon and strategies of neuroprotection, AP.R

• Abstract

  Animal venoms constitute a rich source of pharmacologically active substances. Such molecules, named toxins, act either isolated or in synergy through the binding to cell receptors and/or interfering metabolic pathways fundamental to cell viability, inducing local, systemic and even lethal damage to the victim or pray. Exploring the mechanisms of action of toxins has been relevant for pro…

  Native and recombinant animal toxins: functional, structural and molecular analysis, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  Neurodegenerative diseases are major causes of morbidity and mortality in Western countries. Common mechanisms of toxicity involving mitochondrial damage have been suggested, however, a definitive treatment has yet been found. Therefore, there has been a great interest in the development of neuroprotective compounds for the treatment of neurodegenerative diseases. Toxins animals represent…

  Neuroprotective potential evaluation of a synthetic peptide in neurodegenerative diseases: evaluation of genotoxicity and mutagenicity, BP.PD

• Abstract

  The pesticide trichlorfon (dimethyl 2,2,2-trichloro-1-hydroxyethyl Phosphonate) has been widely used in agricultural production and also the control of vectors that transmit various diseases due to its inhibitory effect of acetylcholinesterase (AChE) in insects. However, the toxicity of organophosphate (OP) is not limited to insects, irreversible effects can be induced in humans, such as …

  In vitro study of the mechanisms of neurotoxicity of the organophosphate trichlorfon: strategies for neuroprotection, BP.MS

• Abstract

  The indiscriminate use of pesticides as a strategy to increase the agricultural productivity has increased the intoxication incidence. Due to the large number of voluntary or involuntary cases of organophosphates (OPs) intoxication, it is necessary to elucidate the mechanism of the irreversible cellular degeneration characteristic of organophosphate-induced delayed neuropathy (OPIDN). The…

  Organophosphate-induced delayed neuropathy: in vitro studies of mechanisms of neurotoxicity and neuroprotection, BP.PD

(Only some records are available in English at this moment)