Abstract
Cisplatin is one of the most widely used and effective chemotherapeutic agents for the treatment of several humanmalignancies. This study evaluated the effects of peri-pubertal cisplatin administration on several reproductive end-points andthe reversibility of these effects in adulthood. Peri-pubertal Wistar male rats (45 days old) were divided into two groups: control(saline 0.9%) and ci…