CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Maria Cristina Cintra Gomes Marcondes in research grants and scholarships supported by FAPESP.
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In our previous works related to cancer and Cachexia the main objectives are to elucidate the metabolic and molecular changes occurred during the development of the cancer cachectic state. Cachexia imposed by cancer, is considered a major problem in the treatment of solid tumors, especially pancreatic, stomach, lung and colon since these patients by intensive mobilization of substrates of…
Background: Cachexia is one of the most important causes of many cancer-related deaths. Cancer-cachexia is a complex metabolic syndrome characterised by involuntary weight loss, mostly due to the skeletal muscle tissue wasting. Leucine supplementation has been used to minimise muscle tissue depletion due to its ability to stimulate protein synthesis pathways and inhibit protein degradatio…
In our laboratory, we have as main objective the elucidation of metabolic and molecular effects of the cachectic state induced by tumour growth. Cancer-cachexia is considered a major problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon cancer, since these patients have intensive mobilization of host tissues, preferably depleting the skeletal muscle pro…
Cancer during pregnancy merges two complex metabolic and hormonal conditions, both poorly understood, which have the potential to exacerbate the condition of both the mother and the foetus. The branched chain amino acid leucine acts to improve cellular activity, especially by increasing protein synthesis. This study aims to analyse the modulatory effect of a leucine-rich diet on tumour-in…
(Only some records are available in English at this moment)
In our previous results related to Cancer and cachexia studied the metabolic and molecular changes occurred during the development of the Cancer cachectic state. Cachexia imposed by Cancer, is considered a major problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon since these patients have an intensive substrate mobilization from host body tissues, sin…
Chemotherapy during pregnancy can be safely recommended, beging in the second trimester of pregnancy. However, placental exposure to chemotherapy is associated with its developmental failures that lead to fetal growth restriction, due to inflammatory pathways activit and synthesis pathways downregulated on placental tissue. Some treatments, such as leucine, progesterone, sitagliptin and l…
(Only some records are available in English at this moment)
The main objective of the physiological alterations of pregnancy is the healthy development of the fetus-pregnant dyad, and, among these alterations, the placenta stands out, which acts as a selective and communication barrier. However, even with the natural protection mechanisms, the organism is subject to suffering of pathologies that can potentially affect the course of pregnancy, and,…
The mechanism of protein catabolism in the skeletal muscle has been widely studied, especially that induced by a proteolysis-inducing factor (PIF; or even by Walker Factor), as occurred in human and experimental animal tumours. These studies include the cellular signaling processes and metabolic pathways involved mainly in the process of cachexia. In our previous studies we observed that …
(Only some records are available in English at this moment)
Cancer cachexia is a complex, systemic, multifactorial syndrome that causes several metabolic alterations, affecting multiple organs, including the heart. Cardiac failures in patients with cancer cachexia have been widely reported, representing a severe problem limiting patient survival, but often underestimated and insufficiently studied. Cancer and heart diseases have been associated wi…
Most ovarian cancers are diagnosed late and have a poor prognosis that hasn't changed significantly over the last 30 years. Screening for ovarian cancer does not appear to reduce mortality therefore, the best chance to reduce mortality from ovarian cancer is prevention and identifying women at high risk. Epidemiology studies have confirmed that 5-10 years of oral contraceptive (OC) use re…
Cachexia is a multi-factorial syndrome that affects up to 80% of cancer patients and is significantly related to decrement of quality of life and cancer deaths. Skeletal muscle wasting is the main consequence of cachexia and largely contributes to involuntary weight loss. This skeletal muscle wasting is a result of an increase in protein breakdown and decrease in protein synthesis. Protei…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 21 / 15 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 34 / 24 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 67 / 51 | All research grants and scholarships |
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