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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Maria Cristina Cintra Gomes Marcondes in research grants and scholarships supported by FAPESP.
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In our previous works related to cancer and Cachexia the main objectives are to elucidate the metabolic and molecular changes occurred during the development of the cancer cachectic state. Cachexia imposed by cancer, is considered a major problem in the treatment of solid tumors, especially pancreatic, stomach, lung and colon since these patients by intensive mobilization of substrates of…
Background: Cachexia is one of the most important causes of many cancer-related deaths. Cancer-cachexia is a complex metabolic syndrome characterised by involuntary weight loss, mostly due to the skeletal muscle tissue wasting. Leucine supplementation has been used to minimise muscle tissue depletion due to its ability to stimulate protein synthesis pathways and inhibit protein degradatio…
In our laboratory, we have as main objective the elucidation of metabolic and molecular effects of the cachectic state induced by tumour growth. Cancer-cachexia is considered a major problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon cancer, since these patients have intensive mobilization of host tissues, preferably depleting the skeletal muscle pro…
Cancer during pregnancy merges two complex metabolic and hormonal conditions, both poorly understood, which have the potential to exacerbate the condition of both the mother and the foetus. The branched chain amino acid leucine acts to improve cellular activity, especially by increasing protein synthesis. This study aims to analyse the modulatory effect of a leucine-rich diet on tumour-in…
(Only some records are available in English at this moment)
Cancer cachexia is a complex, systemic and multifactorial syndrome that cause several metabolic alterations. Skeletal muscle atrophy, the main consequence of cachexia, occurs due to protein imbalance. Protein degradation pathways can be activated by the Walker Factor, a cachexia-inducing protein, and by serum inflammatory cytokines, since inflammation is a common characteristic of cachexi…
In our previous works related to cancer and cachexia, the main objectives are to elucidate the metabolic and molecular changes that occurred during the development of the cachectic cancer state. Cachexia imposed by cancer, is considered a significant problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon since these patients by intensive mobilization of …
(Only some records are available in English at this moment)
The mechanism of protein catabolism in the skeletal muscle has been widely studied, especially that induced by a proteolysis-inducing factor (PIF; or even by Walker Factor), as occurred in human and experimental animal tumours. These studies include the cellular signaling processes and metabolic pathways involved mainly in the process of cachexia. In our previous studies we observed that …
In our previous works related to cancer and cachexia, the main objectives are to elucidate the metabolic and molecular changes that occurred during the development of the cachectic cancer state. Cachexia imposed by cancer, is considered a significant problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon since these patients by intensive mobilization of …
The placenta is the primary organ of communication between mother and foetus and is responsible for ensuring all the necessary sources to guarantee the healthier embryo and foetus development. The placenta establishment and development is in a continuous and organized way. Thus it is possible to evaluate the foetal growth and progress. TGF-² superfamily members are associated with the reg…
(Only some records are available in English at this moment)
Cancer affects about 5% of women under 50 years. In Europe, women between 20 to 49 years had an incidence increase colon cancer, especially related to obesity. Currently, with an increased survival in cancer patients is possible the opportunity of a pregnancy after cancer treatment. Chemotherapeutic agents are one of the main cancer treatments and some problems related to infertility and …
Most ovarian cancers are diagnosed late and have a poor prognosis that hasn't changed significantly over the last 30 years. Screening for ovarian cancer does not appear to reduce mortality therefore, the best chance to reduce mortality from ovarian cancer is prevention and identifying women at high risk. Epidemiology studies have confirmed that 5-10 years of oral contraceptive (OC) use re…
Cachexia is a multi-factorial syndrome that affects up to 80% of cancer patients and is significantly related to decrement of quality of life and cancer deaths. Skeletal muscle wasting is the main consequence of cachexia and largely contributes to involuntary weight loss. This skeletal muscle wasting is a result of an increase in protein breakdown and decrease in protein synthesis. Protei…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 21 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 32 / 22 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 63 / 47 | All research grants and scholarships |
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