CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1980), graduate at Ciências Biológicas from Universidade de São Paulo (1979) and ph.d. at Biochemistry from Universidade de São Paulo (1987). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: breast cancer, cancer de mama, gene expression, cancer and carcinoma. (Source: Lattes Curriculum)
Breast cancer is a complex and heterogeneous disease showing substantial variations in genetics, histopathology and clinical course of the disease and can be defined as a set of conditions with at least four distinct intrinsic molecular subtypes. Intratumoral heterogeneity is the main obstacle to treatment success and personalized medicine application. Despite rapid advancement in the mol…
Breast cancer is a very heterogeneous group of diseases showing substantial variations in their molecular and clinical characteristics. Breast cancer is the most common cancer and the major source of morbidity and mortality among women worldwide. In Brazil, according to data from the Ministry of Health, breast cancer is the most prevalent malignancy after skin cancer and the leading cause…
Breast cancer is the most common cancer and the leading cause of morbidity and mortality among women worldwide. In Brazil, data from cancer registries of the Ministry of Health indicate breast cancer as the second most common malignancy and a major cause of mortality in the female population, with estimates of incidence of 52 000 new cases of breast cancer for the biennium 2012 / 2013, re…
The SPSAS Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment aims to improve the quality of translational cancer research training, and provide opportunities for students and fellows to expand their understanding. Despite tremendous advances in the understanding of their causes, cancer related deaths now exceed those from coronary heart disease and stroke,…
(Only some records are available in English at this moment)
The ovarian steroid hormones progesterone and estrogen play vital roles in the development of normal mammary gland and are likewise linked to mammary carcinogenesis via their receptors. Progesterone receptor (PR) is expressed as two isoforms, PR-A and PR-B. In human breast tumors the PR-A/PR-B expression ratio is altered, with the PR-A isoform predominating. Transgenic mice carrying an ad…
The pro-apoptotic gene PAWR (PKC apoptosis regulator WT1, also known as PAR-4 Prostate apoptosis response-4) is known to selectively induce apoptosis in a variety of cancer cells. High levels of protein kinase A within cells and endoplasmic reticulum stress to PAR-4 confer the ability selectively to cancer, inducing apoptosis by both intrinsic and extrinsic mechanisms. Recently, studies h…
Breast cancer is a common disease with high morbidity and mortality. The etiology of breast cancer is heterogeneous and complex and this neoplastic is considered a multifactorial disease. Genetic predisposition is the major risk factor for breast cancer. The genetic alterations include activation of oncogenes and loss of function of cancer suppressor genes.Studies in our laboratory using …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 16 / 9 | Completed research grants |
| 32 / 7 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 50 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 15 |
| Citations | 184 |
| Cit./Article | 12.3 |
| Data from Web of Science | |
DO AMARAL, JONATAS BUSSADOR; URABAYASHI, MARCEL SHINITI; MACHADO-SANTELLI, GLAUCIA MARIA. Cell death and lumen formation in spheroids of MCF-7 cells. Cell Biology International, v. 34, n. 3, p. 267-274, MAR 2010. Web of Science Citations: 12. (06/01026-0)
NAGAI, MARIA APARECIDA; GERHARD, RENE; SALAORNI, SIBELI; TAVARES GUERREIRO FREGNANI, JOSE HUMBERTO; NONOGAKI, SUELY; NETTO, MARIO MOURAO; SOARES, FERNANDO AUGUSTO. Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer. International Journal of Oncology, v. 37, n. 1, p. 41-49, JUL 2010. Web of Science Citations: 27. (06/01026-0)
NAGAI, MARIA APARECIDA; GERHARD, RENE; FREGNANI, JOSE HUMBERTO T. G.; NONOGAKI, SUELY; RIERGER, REGINA BARBOSA; NETTO, MARIO MOURAO; SOARES, FERNANDO A.. Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients. Breast Cancer Research and Treatment, v. 126, n. 1, p. 1-14, FEB 2011. Web of Science Citations: 54. (06/01026-0)
BONATTO, NAIELI; CARLINI, MARIA JOSE; DE BESSA GARCIA, SIMONE APARECIDA; NAGAI, MARIA APARECIDA. PHLDA1 (pleckstrin homology-like domain, family A, member 1) knockdown promotes migration and invasion of MCF10A breast epithelial cells. CELL ADHESION & MIGRATION, v. 12, n. 1, p. 37-46, 2018. Web of Science Citations: 1. (15/10208-3)
SANTOS, MARIANA LOPES DOS; PALANCH, CAROLINA GONÇALVES; SALAORNI, SIBELI; SILVA, WILSON ARAUJO DA; NAGAI, MARIA APARECIDA. Transcriptome characterization of human mammary cell lines expressing different levels of ERBB2 by serial analysis of gene expression. International Journal of Oncology, v. 28, n. 6, p. 1441-1461, June 2006.
BESSA, SIMONE APARECIDA DE; SALAORNI, SIBELI; PATRÃO, DIOGO F. C.; MOURÃO NETO, MÁRIO; BRENTANI, MARIA MITZI; NAGAI, MARIA APARECIDA. JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status. International Journal of Molecular Medicine, v. 17, n. 2, p. 363-367, Feb. 2006.
BUIM‚ M.E.; SOARES‚ F.A.; SARKIS‚ Á.S.; NAGAI‚ M.A.. The Transcripts of SFRP1‚ CEP63 and EIF4G2 Genes Are Frequently Downregulated in Transitional Cell Carcinomas of the Bladder. ONCOLOGY, v. 69, n. 6, p. 445-454, 2005.
FREITAS, VANESSA M.; DO AMARAL, JONATAS BUSSADOR; SILVA, THAIOMARA A.; SANTOS, EMERSON S.; MANGONE, FLAVIA R.; PINHEIRO, JOAO DE JESUS; JAEGER, RUY G.; NAGAI, MARIA A.; MACHADO-SANTELLI, GLAUCIA MARIA. Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion. Molecular Cancer, v. 12, JAN 5 2013. Web of Science Citations: 25. (10/07699-1, 06/01026-0)
PEREIRA, MICHELLY C.; DE BESSA-GARCIA, SIMONE A.; BURIKHANOV, RAVSHAN; PAVANELLI, ANA CAROLINA; ANTUNES, LOURIVAL; RANGNEKAR, VIVEK M.; NAGAI, MARIA A.. Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells. International Journal of Oncology, v. 43, n. 2, p. 531-538, AUG 2013. Web of Science Citations: 11. (10/16543-5)
DO AMARAL, JONATAS BUSSADOR; REZENDE-TEIXEIRA, PAULA; FREITAS, VANESSA MORAIS; MACHADO-SANTELLI, GLAUCIA MARIA. MCF-7 Cells as a Three-Dimensional Model for the Study of Human Breast Cancer. TISSUE ENGINEERING PART C-METHODS, v. 17, n. 11, p. 1097-1107, NOV 2011. Web of Science Citations: 21. (06/01026-0)
CASOLARI, DEBORA A.; PEREIRA, MICHELLY C.; DE BESSA GARCIA, SIMONE A.; NAGAI, MARIA A.. Insulin-like growth factor-1 and 17 beta-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells. International Journal of Molecular Medicine, v. 28, n. 3, p. 337-342, SEP 2011. Web of Science Citations: 7. (06/01026-0)
MARCHIORI, A. C.; CASOLARI, D. A.; NAGAI, M. A.. Transcriptional up-regulation of PHLDA1 by 17 beta-estradiol in MCF-7 breast cancer cells. Brazilian Journal of Medical and Biological Research, v. 41, n. 7, p. 579-582, JUL 2008. Web of Science Citations: 10. (04/04607-8, 06/01026-0)
CARLINI, MARIA JOSE; RECOUVREUX, MARIA SOL; SIMIAN, MARINA; NAGAI, MARIA APARECIDA. Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands. BMC CANCER, v. 18, JUN 25 2018. Web of Science Citations: 1. (14/13470-8, 15/10208-3)
DE ALCANTARA FILHO, PAULO R.; MANGONE, FLAVIA R.; PAVANELLI, ANA C.; DE BESSA GARCIA, SIMONE A.; NONOGAKI, SUELY; DE TOLEDO OSORIO, CYNTHIA A. B.; DE ANDRADE, VICTOR P.; NAGAI, MARIA A.. Gene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC). BREAST CANCER MANAGEMENT, v. 7, n. 2, MAY 2018. Web of Science Citations: 0. (13/07035-4)
DE BESSA GARCIA, SIMONE APARECIDA; PAVANELLI, ANA CAROLINA; CRUZ E MELO, NATALIA; NAGAI, MARIA APARECIDA. Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. International Journal of Molecular Medicine, v. 39, n. 4, p. 809-818, APR 2017. Web of Science Citations: 5. (13/07035-4)
NAGAI, MARIA APARECIDA; RÓS, NANCY DA; MOURÃO NETO, MÁRIO; FARIA JÚNIOR, SILVIO RODRIGUES DE; BRENTANI, MARIA MITZI; HIRATA JÚNIOR, ROBERTO; NEVES, EDUARDO JORDÃO. Gene expression profiles in breast tumors regarding the presence or absence of estrogen and progesterone receptors. International Journal of Cancer, v. 111, n. 6, p. 892-899, Oct. 2004.
GARCIA, S. A. B.; NAGAI, M. A.. Transcriptional regulation of bidirectional gene pairs by 17 beta-estradiol in MCF-7 breast cancer cells. Brazilian Journal of Medical and Biological Research, v. 44, n. 2, p. 112-122, FEB 2011. Web of Science Citations: 4. (06/01026-0)
DOS SANTOS, M. L.; GIMENES, K. P.; SILVA, JR., W. A.; NAGAI, M. A.. Transcriptome changes induced by docetaxel in human mammary cell lines expressing different levels of ERBB2. International Journal of Molecular Medicine, v. 23, n. 6, p. 733-743, JUN 2009. Web of Science Citations: 6. (06/01026-0)
MANGONE, FLAVIA R.; VALOYES, MAIRA A. V.; DO NASCIMENTO, RENAN G.; CONCEICAO, MERCIA P. F.; BASTOS, DANIEL R.; PAVANELLI, ANA C.; SOARES, IBERE C.; DE MELLO, EVANDRO S.; NONOGAKI, SUELY; OSORIO, CYNTHIA A. B.; et al. Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer. BIOMARKERS IN MEDICINE, v. 14, n. 16, p. 1539-1554, NOV 2020. Web of Science Citations: 0. (19/05252-4)
(References retrieved automatically from State of São Paulo Research Institutions)
FILHO, Lourival Antunes de Oliveira. Papel da expressão celular e extracelular do Par-4 na formação tumoral e sensibilidade a droga. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (13/08110-0)
CASOLARI, Débora Arcieri. Interação entre as vias de sinalização do IGF-I, do ER e da integrina 1 na regulação da transcrição do genes PHLDA1 e PAWR. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (05/04183-6)
CAMILLO, Cláudia Malheiros Coutinho. Análise da expressão deferencial de genes em linhagens celulares de carcinoma de próstata. 130 f. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (00/00196-2)
PAVANELLI, Ana Carolina. Avaliação do transcriptoma e proteoma de células de câncer de mama com diferente perfil de expressão de SPARC (secreted protein acidic and rich in cysteine) na presença e ausência de docetaxel. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (12/03920-0)