CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Maria A Nagai received her bachelor's degree in Biology at the University of São Paulo (1980) and her Ph.D. in Biochemistry at the University of São Paulo (1987). Postdoctoral fellowship at Cancer Research Campaign Human Cancer Genetics Research Group, Department of Pathology, University of Cambridge, Cambridge, UK, 1993. She is an Associate Professor at the Discipline of Oncology, Department of Radiology and Oncology, Medical School, University of São Paulo. Coordinator of the Molecular Genetics Laboratory and DNA Sequencing Core Facility at the Center for Translational Oncology, Cancer Institute for the State of São Paulo. Her research projects have received continuous funding from Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). She has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: solid tumors, breast cancer, gene expression, 2D and 3D cell culture, functional genomics, and molecular genetics. Her lab focuses on identifying and characterizing new molecular prognostic and predictive biomarkers in breast cancer. (Source: Lattes Curriculum)
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Breast cancer is a complex and heterogeneous disease showing substantial variations in genetics, histopathology and clinical course of the disease and can be defined as a set of conditions with at least four distinct intrinsic molecular subtypes. Intratumoral heterogeneity is the main obstacle to treatment success and personalized medicine application. Despite rapid advancement in the mol…
Breast cancer is a very heterogeneous group of diseases showing substantial variations in their molecular and clinical characteristics. Breast cancer is the most common cancer and the major source of morbidity and mortality among women worldwide. In Brazil, according to data from the Ministry of Health, breast cancer is the most prevalent malignancy after skin cancer and the leading cause…
(Only some records are available in English at this moment)
Breast cancer (BC) is the most frequent malignancy in women worldwide. BC is a highly heterogeneous disease, with multiple tumor subtypes, which present distinct morphology and molecular characteristics with implications on the clinical course of the disease. Despite advances in the molecular classification of breast cancer, there is still a need to identify new biomarkers for prognosis a…
The ovarian steroid hormones progesterone and estrogen play vital roles in the development of normal mammary gland and are likewise linked to mammary carcinogenesis via their receptors. Progesterone receptor (PR) is expressed as two isoforms, PR-A and PR-B. In human breast tumors the PR-A/PR-B expression ratio is altered, with the PR-A isoform predominating. Transgenic mice carrying an ad…
The pro-apoptotic gene PAWR (PKC apoptosis regulator WT1, also known as PAR-4 Prostate apoptosis response-4) is known to selectively induce apoptosis in a variety of cancer cells. High levels of protein kinase A within cells and endoplasmic reticulum stress to PAR-4 confer the ability selectively to cancer, inducing apoptosis by both intrinsic and extrinsic mechanisms. Recently, studies h…
(Only some records are available in English at this moment)
| 18 / 11 | Completed research grants |
| 33 / 8 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 52 / 19 | All research grants and scholarships |
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