CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1980), graduate at Ciências Biológicas from Universidade de São Paulo (1979) and ph.d. at Biochemistry from Universidade de São Paulo (1987). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: breast cancer, cancer de mama, gene expression, cancer and carcinoma. (Source: Lattes Curriculum)
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Breast cancer is a complex and heterogeneous disease showing substantial variations in genetics, histopathology and clinical course of the disease and can be defined as a set of conditions with at least four distinct intrinsic molecular subtypes. Intratumoral heterogeneity is the main obstacle to treatment success and personalized medicine application. Despite rapid advancement in the mol…
Breast cancer is a very heterogeneous group of diseases showing substantial variations in their molecular and clinical characteristics. Breast cancer is the most common cancer and the major source of morbidity and mortality among women worldwide. In Brazil, according to data from the Ministry of Health, breast cancer is the most prevalent malignancy after skin cancer and the leading cause…
Breast cancer is the most common cancer and the leading cause of morbidity and mortality among women worldwide. In Brazil, data from cancer registries of the Ministry of Health indicate breast cancer as the second most common malignancy and a major cause of mortality in the female population, with estimates of incidence of 52 000 new cases of breast cancer for the biennium 2012 / 2013, re…
The SPSAS Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment aims to improve the quality of translational cancer research training, and provide opportunities for students and fellows to expand their understanding. Despite tremendous advances in the understanding of their causes, cancer related deaths now exceed those from coronary heart disease and stroke,…
(Only some records are available in English at this moment)
The ovarian steroid hormones progesterone and estrogen play vital roles in the development of normal mammary gland and are likewise linked to mammary carcinogenesis via their receptors. Progesterone receptor (PR) is expressed as two isoforms, PR-A and PR-B. In human breast tumors the PR-A/PR-B expression ratio is altered, with the PR-A isoform predominating. Transgenic mice carrying an ad…
The pro-apoptotic gene PAWR (PKC apoptosis regulator WT1, also known as PAR-4 Prostate apoptosis response-4) is known to selectively induce apoptosis in a variety of cancer cells. High levels of protein kinase A within cells and endoplasmic reticulum stress to PAR-4 confer the ability selectively to cancer, inducing apoptosis by both intrinsic and extrinsic mechanisms. Recently, studies h…
Breast cancer is a common disease with high morbidity and mortality. The etiology of breast cancer is heterogeneous and complex and this neoplastic is considered a multifactorial disease. Genetic predisposition is the major risk factor for breast cancer. The genetic alterations include activation of oncogenes and loss of function of cancer suppressor genes.Studies in our laboratory using …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 16 / 9 | Completed research grants |
| 32 / 7 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 50 / 17 | All research grants and scholarships |
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