graduation at Medicina from Universidade Estadual de Campinas (1984), master's at Immunology from Universidade Estadual de Campinas (1990) and doctorate at Pharmacology from Universidade de São Paulo (1994). He is currently professor of experimental medicine at Universidade de São Paulo. Has experience in Medicine, focusing on Allergology and Clinical Imunology, acting on the following subjects: fagócitos, asma, inflamação, neutrófilos and superóxido. (Source: Lattes Curriculum)
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Primary immunodeficiencies are a group of approximately 300 diseases that may present with increased susceptibility to infections, autoimmunity, inflammation, allergies, and increased susceptibility to Cancer. In the present proposal, we will investigate chronic granulomatous disease (CGD), X-linked Hyper IgM Syndrome (X-HIGM), and Severe Combined Immunodeficiency (SCID). As well, we will…
Healthy aging and longevity are a growing topic of interest. They depend on the complex interplay between nuclear and mitochondrial DNA, the environment and the microbiota, that is, the whole set of bacteria living in the different parts of our body with their whole set of genes. Understanding this complex nature versus nurture balance is one of the greatest challenges in human genetics a…
Allergic diseases are a global public health problem due to exposure to a wide range of allergens in genetically predisposed people. The diagnosis of allergy is usually made on the basis of clinical history, skin prick test and the quantification of allergen-specific IgE. However, the allergy diagnosis is compromised in pediatric age and elderly patients due to immaturity and senescence o…
5:00 Welcome and Opening Ceremony 6:00-6:30 PM PID around the world: are these diseases the same? 6:30-7:00 PM Life-threatening infectious diseases: monogenic inborn errors of immunity OCTOBER 5TH, 2017 8:30-10:00 Infections and PID 10:30-11:00 "Complement deficiencies: what is new?" 11:00-12:00 Clinical Cases Session: 3 select cases 2:00-3:30pm Autoimmunity 3:30-4:00 pm Conference: "Ne…
Primary immunodeficiencies are a group of more than 200 different diseases associated with genetic disorders that affect the development and/or function of the immune system. Many of them can cause death during the first year of life if not treated in time, however, a timely therapy allows patients to survive to adulthood. For this to occur, early diagnosis of immunodeficiency based on a …
(Only some records are available in English at this moment)
Primary Immunodeficiencies (PIDs) are a heterogeneous group of genetic diseases with repercussions on the immune response. Severe Combined Immunodeficiency (SCID) is characterized by high T lymphocyte deficiency, which affects cellular and humoral immunity, and generates severe abnormalities in the development and functions of the immune system. Newborns with SCID present the disease in t…
Chronic granulomatous disease (GDD) is a rare immunodeficiency that affects the microbicidal function of phagocytes due mutations in the NADPH oxidase system, causing susceptibility to recurrent infections, granulomas, and hyperinflammation. DGC Patients have a defect in the production of reactive oxygen species (ROS), failure of neutrophil extracellular traps (NETs) formation, and increa…
The Zika Virus is a neurotropic flavivirus that has recently emerged in the Americas and has become an international public health problem. The increase in the prevalence of ZIKV infections in Brazil coincided with an increase in the occurrence of Microcephaly cases and other neurological complications in neonates caused by fetal neuronal lesions, coining the Zika Congenital Syndrome. The…
Primary immunodeficiencies (PIDs) are a heterogeneous group of genetic diseases with repercussions on the immune response. Severe combined immunodeficiency (SCID) is characterized by high T lymphocyte deficiency, which affects cellular and humoral immunity, and generates severe abnormalities in the development and functions of the immune system. Newborns with SCID present the disease in …
(Only some records are available in English at this moment)
The NADPH oxidase system is an enzymatic complex that generates superoxide. It is formed by membrane components, gp91-phox and p22-phox subunits (flavocytochrome b558), and cytoplasmic components (p47-phox, p67-phox and p40-phox). Defects in the expression of these components lead to Chronic Granulomatous Disease (CGD), a severe primary immunodeficiency characterized by the early onset of…
High-throughput RNA sequencing (RNA-seq) is a powerful method for discovering, profiling and quantifying RNA transcripts, turning into possible its use for indentifying splicing events. However, the need for RNA-seq data analysis and interpretation still remains a big hurdle for many research and clinical applications. One of the main goals of this project is to identify the differentiall…
Severe Combined Immunodeficiency (SCID) is the most severe form of primary immunodeficiency and is characterized by the absence or dysfunction of T lymphocytes, associated with a defective antibody response, which might result from intrinsic defects in B lymphocytes or inadequate T-cell activity. If left untreated, SCID patients will eventually die by their second year of life and this ma…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 29 / 16 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 45 / 21 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 83 / 46 | All research grants and scholarships |
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CV Lattes
ORCID