Full time professor at the School of Dentistry of Ribeirão Preto (FORP) - University of São Paulo (USP). Specialist and MSc in Pediatric Dentistry and PhD in Sciences, degrees conferred by FORP-USP. During the PhD course did an internship at the Mesenchymal Biology and Signaling Laboratory at the School of Dentistry at University of Michigan (Ann Arbor, USA). Post-doctoral fellow in Immunology at the Laboratory of Inflammation and Immunology of Parasitic Infections at the School of Pharmaceutical Sciences of Ribeirão Preto-USP. Interest in basic research with clinical application, with emphasis on the relationship between immune response, cellular differentiation and mineralized tissue metabolism (bone and teeth). Ad-hoc revisor for CAPES, FAPESP and several scientific journals (Source: Lattes Curriculum)
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Microbial or traumatic dental injuries can result in pathological resorption of mineralized tissue (bone and tooth). This research proposal aims to investigate the mechanisms involved in two models of bone and dental resorption, resulting from root canal infection and from dental avulsion and replantation. To assess the mechanisms involved in the process of bone and dental resorption of m…
Tumor necrosis factor-z (TNF-z) role in in vitro induction of dental pulp cell proliferation, migration and differentiation of dental pulp cells is already known and indicates that this mediator might be and important regulator of the recruitment of cells to injured sites for tissue regeneration or repair. Nevertheless, all these phenomena were demonstrated in vitro in cell culture models…
Apical periodontitis represents a localized immune-inflammatory response directed against microorganisms inside the root canal. Previously we have demonstrated a poor bone healing following root canal treatment, indicating that improper root canal therapy has been used probably due to the low understanding of the dynamics of the pathology. Therefore, the investigation of the biological me…
(Only some records are available in English at this moment)
Objective: This study aims to investigate tooth resorption resulting from endodontic infection, in the presence or absence of TNF-z receptor-1 (TNFR1). Methods: To evaluate the mechanisms involved in the process of tooth resorption, 10 C57BL/6 mice (Wild-type; wild) and 10 mice genetically deficient (knockout) of TNFR1 will be used. For induction of apical periodontitis, the animals will …
The recommended treatment for avulsed teeth in youngsters is dental reimplantation, but tooth survival is low and dependent on the extra-alveolar time and on the storage medium in which the tooth was stored. Considering that most reimplants are performed at a late stage when root surface cells have lost viability, it is necessary to conduct studies that aim to identify substances that pre…
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine released by macrophages in the immune- inflammatory response, with a role in induction cell proliferation, migration and differentiation of dental pulp cells. This study aims to evaluate the hypothesis that TNF-alpha signaling via TNFR1 results in inhibition of mineralization, while signaling via TNFR2 leads to cell differentiation. Th…
Tumor Necrosis Factor-alpha (TNF-alpha) role in in vitro induction of dental pulp cell proliferation, migration and differentiation of dental pulp cells is already known and indicates that this mediator might be and important regulator of the recruitment of cells to injured sites for tissue regeneration or repair. Nevertheless, all these phenomena were demonstrated in vitro in cell cultur…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 14 / 7 | Completed scholarships in Brazil |
| 21 / 13 | All research grants and scholarships |
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CV Lattes
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