CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (FORP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
master's at Physiology from Universidade de São Paulo (1990) and ph.d. at Physiology from Universidade de São Paulo (1993). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: hipotermia, temperatura corporal, óxido nítrico, hypoxia and toad. (Source: Lattes Curriculum)
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The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of…
Hydrogen sulfide (H2S), recently described as the third member of the group of gaseous transmitters, is produced endogenously by metabolic pathways with predominant participation of two enzymes: cystathionine beta-synthase (CBS ) and cystathionine gamma-lyase (CSE ). The presence and participation of CBS and CSE for generating H2S in response to hypoxia have been reported in the carotid b…
Hydrogen sulfide (H2S) has been recently appointed as an important endogenous gas acting during systemic inflammation. In animal models of systemic inflammation, H2S basal levels are altered in the preoptic area of the hypothalamus (POA) in response to the administration of endotoxin (bacterial lipopolysaccharide, LPS). Furthermore, we demonstrated that H2S in POA modulates the febrile re…
Tonic immobility (IT) is a behavioral defensive innate fear triggered in situations of inescapable confrontation between predator-prey. This response is characterized by loss of righting reflex and the relative lack of responsiveness to environmental stimuli. Consistent studies have shown the involvement of different brain areas to modulate this response, including the periaqueductal gray…
(Only some records are available in English at this moment)
The activation of the Angiotensin-converting enzyme 2 (ACE2), a component of the counter-regulatory axis of the Renin-Angiotensin System, has been reported as a potential target in the control of systemic inflammation. ACE2 is essential for the functioning of the intestinal transporter B(0)AT1, responsible for the absorption of tryptophan, a precursor of serotonin (5-HT). 5-HT is essentia…
Sepsis, an organic dysfunction resulting from a dysregulated response to an infection, has a complex pathophysiology, mainly associated with the excessive production of inflammatory mediators. These mediators have deleterious actions to the body, not only in the acute phase of the disease, but also promote persistent changes in those who survive Sepsis, such as cognitive and memory defici…
(Only some records are available in English at this moment)
Obstructive sleep apnea (OSA) is a severe breathing disorder, characterized by periodic obstruction of the upper airways during sleep with eventual impact in the cardiovascular and respiratory systems as well as in the inflammatory status. OSA and its critical respiratory complications may be associated with obesity hypoventilation syndrome. Previous studies have documented the role of le…
5-hydroxytryptamine (5-HT) plays key thermoregulatory role acting in the central nervous system (CNS). 5-HT spinal administration results in hypothermia and emerging data demonstrate that activation of 5-HT receptors within the intermediolateral column (IML) of the spinal cord increases the sympathetic outflow to brown adipose tissue (BAT). In agreement, endogenous 5-HT1A and 5-HT7 recept…
Sex hormones, such as estradiol, play an important role in body temperature regulation and pain sensation. Low estradiol concentrations, often seen in menopausal women, are associated with the occurrence of hot flushes, which are characterized by an intense sensation of heat, followed by profuse sweating and an increase in blood flow to the skin, which leads to reddening of the face and u…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 21 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 51 / 18 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 81 / 38 | All research grants and scholarships |
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