CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (FORP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
master's at Physiology from Universidade de São Paulo (1990) and ph.d. at Physiology from Universidade de São Paulo (1993). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: hipotermia, temperatura corporal, óxido nítrico, hypoxia and toad. (Source: Lattes Curriculum)
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The objective of this proposal is to obtain resources for the purchase of a -70°C freezer, as several laboratories in this Unit have always used small spaces provided by Dr. Del-Bel. However, this equipment reached its maximum capacity, forcing us to request this funding from FAPESP, when submitting the "parent" Project (Regular Research Project 2022/12290-2) which had not been granted by…
Periodontitis is an inflammatory, non-communicable disease that affects the protective and supporting tissue, and presents scaling and root planing as standard treatment. In recent years, different therapeutic strategies have been proposed for the adjuvant treatment of periodontal diseases, but little is known about how natural substances can interact with the progression of periodontal d…
The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of…
Hydrogen sulfide (H2S), recently described as the third member of the group of gaseous transmitters, is produced endogenously by metabolic pathways with predominant participation of two enzymes: cystathionine beta-synthase (CBS ) and cystathionine gamma-lyase (CSE ). The presence and participation of CBS and CSE for generating H2S in response to hypoxia have been reported in the carotid b…
Hydrogen sulfide (H2S) has been recently appointed as an important endogenous gas acting during systemic inflammation. In animal models of systemic inflammation, H2S basal levels are altered in the preoptic area of the hypothalamus (POA) in response to the administration of endotoxin (bacterial lipopolysaccharide, LPS). Furthermore, we demonstrated that H2S in POA modulates the febrile re…
(Only some records are available in English at this moment)
Inflammation is a physiological process crucial for tissue protection and repair but can lead to complications when dysregulated. In the central nervous system (CNS), inflammation plays a significant role in traumatic brain injury (TBI), where primary brain damage is followed by prolonged neuroinflammation, contributing to severe behavioral, neuropsychiatric, neurodegenerative, and cognit…
Periodontitis is a chronic, multifactorial, and non-communicable inflammatory condition that affects the supportive and protective tissues of the teeth. As a result, numerous therapeutic strategies are proposed to complement the treatment of periodontal diseases. However, there is a gap in understanding how natural substances may interact within the context of periodontal disease progress…
Orofacial pain, including those associated with Temporomandibular Disorders (TMDs), has a notable prevalence and complexity, with a multifactorial etiology. The therapeutic approach to TMDs requires a multidisciplinary perspective, including non-invasive therapies and, in some cases, surgical procedures. This study aims to evaluate the efficacy of a carbon monoxide donor (CORM-401) admini…
(Only some records are available in English at this moment)
Periodontitis is an inflammatory disease that affects the protective and supportive tissue, with scaling and root planing as the standard treatment. In recent years, different therapeutic strategies have been proposed for the adjuvant treatment of periodontal pathologies, but little is known about how natural substances can interact with the progression of periodontal disease and the host…
In dentistry, acute inflammation in the orofacial region has great relevance, since it favors the production of edema, pain, and discomfort to the patient. The use of experimental models is fundamental for the production of knowledge on the subject. Currently, vascular permeability in the orofacial region is invariably evaluated by means of the Evans Blue test, in murine models. However, …
Systemic inflammation associated syndromes are linked to high mortality rates and remain a challenge in emergency medicine. The administration of lipopolysaccharide (LPS) mimics systemic inflammation in an experimental animal model that produces pro-inflammatory cytokines such as TNF-±, IL-1² and IL-6, in addition to changes in body temperature, such as fever and hypothermia, depending on…
(Only some records are available in English at this moment)
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth, leading to bone loss and potentially tooth loss. The disease arises from an imbalance between the oral microbiota and the host immune response, resulting in bacterial colonization, particularly by Porphyromonas gingivalis. Standard treatment typically involves mechanical debridement, often combi…
The inflammatory reflex (IR) is a classic neural reflex composed of an afferent arm that perceives the immune challenge and transmits the information from the immune system to the central nervous system. Here specific areas elaborate this information and, in turn, activate an efferent arm that inhibits the production of pro-inflammatory cytokines and enhances that of anti-inflammatory med…
Ischemic stroke is a leading cause of death and disability in the world. Still, even nowadays, there are a limited number of treatments for these patients. Another problem is that successful stroke treatment requires rapid intervention. Because of such limitations, stroke treatments so far have had only a modest impact on the outcomes of patients. Brain or body cooling has been thought to…
Obstructive sleep apnea (OSA) is a severe breathing disorder, characterized by periodic obstruction of the upper airways during sleep with eventual impact in the cardiovascular and respiratory systems as well as in the inflammatory status. OSA and its critical respiratory complications may be associated with obesity hypoventilation syndrome. Previous studies have documented the role of le…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 23 / 13 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 55 / 22 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 7 | Completed scholarships abroad |
| 94 / 50 | All research grants and scholarships |
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