master's at Physiology from Universidade de São Paulo (1990) and ph.d. at Physiology from Universidade de São Paulo (1993). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: hipotermia, temperatura corporal, óxido nítrico, hypoxia and toad. (Source: Lattes Curriculum)
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Neuroimmune interactions have been extensively explored in order to find new therapeutic targets for inflammatory diseases. With the discovery of the "cholinergic anti-inflammatory pathway", several studies were conducted exploring the anti-inflammatory potential of the vagus nerve. However, more recently, evidence has suggested that baroreceptors (essential for arterial pressure control)…
The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of…
Hydrogen sulfide (H2S), recently described as the third member of the group of gaseous transmitters, is produced endogenously by metabolic pathways with predominant participation of two enzymes: cystathionine beta-synthase (CBS ) and cystathionine gamma-lyase (CSE ). The presence and participation of CBS and CSE for generating H2S in response to hypoxia have been reported in the carotid b…
Hydrogen sulfide (H2S) has been recently appointed as an important endogenous gas acting during systemic inflammation. In animal models of systemic inflammation, H2S basal levels are altered in the preoptic area of the hypothalamus (POA) in response to the administration of endotoxin (bacterial lipopolysaccharide, LPS). Furthermore, we demonstrated that H2S in POA modulates the febrile re…
(Only some records are available in English at this moment)
In dentistry, acute inflammation in the orofacial region has great relevance, since it favors the production of edema, pain, and discomfort to the patient. The use of experimental models is fundamental for the production of knowledge on the subject. Currently, vascular permeability in the orofacial region is invariably evaluated by means of the Evans Blue test, in murine models. However, …
Systemic inflammation associated syndromes are linked to high mortality rates and remain a challenge in emergency medicine. The administration of lipopolysaccharide (LPS) mimics systemic inflammation in an experimental animal model that produces pro-inflammatory cytokines such as TNF-±, IL-1² and IL-6, in addition to changes in body temperature, such as fever and hypothermia, depending on…
Recent studies have been shown an increased incidence of Cardiovascular Diseases (CVDs) in surviving patients of Sepsis and septic shock. Several inflammatory mediators have been considered to be responsible for this cardiovascular changes which can occurs between 1 and 5 years after the previous infection. The activation of the Renin Angiotensin System (RAS) and the increase of proinflam…
(Only some records are available in English at this moment)
Sepsis, an organic dysfunction resulting from a dysregulated response to an infection, has a complex pathophysiology, mainly associated with the excessive production of inflammatory mediators. These mediators have deleterious actions to the body, not only in the acute phase of the disease, but also promote persistent changes in those who survive Sepsis, such as cognitive and memory defici…
(Only some records are available in English at this moment)
Ischemic stroke is a leading cause of death and disability in the world. Still, even nowadays, there are a limited number of treatments for these patients. Another problem is that successful stroke treatment requires rapid intervention. Because of such limitations, stroke treatments so far have had only a modest impact on the outcomes of patients. Brain or body cooling has been thought to…
Obstructive sleep apnea (OSA) is a severe breathing disorder, characterized by periodic obstruction of the upper airways during sleep with eventual impact in the cardiovascular and respiratory systems as well as in the inflammatory status. OSA and its critical respiratory complications may be associated with obesity hypoventilation syndrome. Previous studies have documented the role of le…
5-hydroxytryptamine (5-HT) plays key thermoregulatory role acting in the central nervous system (CNS). 5-HT spinal administration results in hypothermia and emerging data demonstrate that activation of 5-HT receptors within the intermediolateral column (IML) of the spinal cord increases the sympathetic outflow to brown adipose tissue (BAT). In agreement, endogenous 5-HT1A and 5-HT7 recept…
Sex hormones, such as estradiol, play an important role in body temperature regulation and pain sensation. Low estradiol concentrations, often seen in menopausal women, are associated with the occurrence of hot flushes, which are characterized by an intense sensation of heat, followed by profuse sweating and an increase in blood flow to the skin, which leads to reddening of the face and u…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 23 / 13 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 52 / 19 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 5 | Completed scholarships abroad |
| 89 / 45 | All research grants and scholarships |
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