Yara Maria Lucisano Valim

• Abstract

  Neutrophils are part of the innate immune system and play a crucial role in the first line of defense against microorganisms. The activation of these cells triggers the processes of phagocytosis, degranulation and activation of oxidative metabolism, acting jointly, to the death of pathogens. Then, these cells undergo apoptosis, a process essential for controlling and ending of inflammator…

  Systematic study of the molecular mechanisms involved in the inhibition of the oxidative metabolism of the stimulated neutrophils by the Baccharis dracunculifolia, 3-phenylcoumarin derivatives and 3,5,7-triidroxiflavonaimplications on the RA therapeutics, AP.R

• Abstract

  Neutrophils are essential cells for the body defense against invading microrganisms, by acting through phagocytosis, lysosomal enzyme release and reactive oxygen species (ROS) generation. The last function is mediated by the NADPH oxidase complex, which produces superoxide anion, and by myeloperoxidase (MPO), which generates halogenated reactive species such as HOCl. In some inflammatory …

  Study of the mechanism of action of coumarin derivatives on the myeloperoxidase activity: investigation about metabolization of these compounds to phenoxyl free radicals, implications on the oxidative stress and modulation of leukocyte functions, AP.R

• Abstract

  In inflammatory process, neutrophils have an important participation on the phagocytosis, including the production of reactive species of oxygen and lytic lisosomal enzymes and this process can be stimulated by several ways. However, these reactive species and enzymes present in granules can extravasate to extracellularmedium and lead to injury for host cells as that occur in disease by i…

  Study of effect of composition of liposome containing flavonoids on Complement System activation and oxidative metabolism of human neutrophils: implications in the stability and application of this delivery system in the therapy of inflammatory diseases, AP.R

• Abstract

  Neutrophils or polymorphonuclear (PMN) cells are phagocytic with functions highly potent bactericidal and fungicidal. These cells are able to kill microorganisms through mechanisms independent of oxygen (phagocytosis and degranulation) , and oxygen dependent (production of reactive oxygen species). However, in severe situations of cellular activation , release of large cytotoxic molecules…

  Functional and biochemical study of neutrophils from patients with Rheumatoid Arthritis and its implications in the search for new therapeutic strategies, BP.PD

• Abstract

  Neutrophils are part of the innate immune system and play a crucial role in the first line of defense against microorganisms, characterized by the functions to recognize, phagocytose and destroy pathogens. The activation of neutrophils via Fc³ and CR receptors triggers processes of phagocytosis, degranulation and activation of oxidative metabolism, which act together to the death of patho…

  In vitro evaluation of antioxidant and anti-inflammatory derivatives 3-phenylcoumarins in human neutrophils stimulated and in animal models of arthritis., BP.DR

• Abstract

  Neutrophils or Polymorphonuclear (PMN) are phagocytic cells with functions highly potent bactericidal and fungicidal. These cells are capable of killing microorganisms through mechanisms independent of oxygen (with degranulation and release of antimicrobial molecules) and oxygen-dependent (with the production of reactive oxygen species). However, in situations of intense cellular activati…

  Evaluation of the stability of the extract dracunculifolia Baccharis (Asteraceae) in antioxidant activity and the modulatory action of this plant on the oxidative metabolism of neutrophils, BP.IC

(Only some records are available in English at this moment)