CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Engenharia Química from Universidade de Mogi das Cruzes (1978), master's at Biochemistry from Universidade Federal de São Paulo (1983) and ph.d. at Biochemistry from Universidade Federal de São Paulo (1992). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: kallikrein, substrato fluorescente, kallikreins, cysteine protease and trypanosoma cruzi. (Source: Lattes Curriculum)
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We have been using mass spectrometry since 1994 as a control tool in the parallel synthesis of peptides established by us since 1990 and this experience has accredited us to use mass spectrometry during development of new projects, as well as in the complementary projects. For 03 years UNIFESP has been structuring the area of oncology, adding researchers from different areas and different…
Considerable progress in the study of proteases was based on the development of synthetic peptides, which resulted in the chromogenic and fluorescent substrates. Quenched fluorescent peptides based on the transfer of energy by resonance of a fluorescent to a quancher group was the more recent and significant progress in the field that we are involve since 1990's. The synthesis of these FR…
The project covers developments of organic syntheses focused on the peptides, peptideomimetics and amino acids and libraries of peptides aimed at the study of proteases. In view of the diversity of proteolytic enzymes that we will be dealing with and because of the involvement of the same in different physiological or physiopathological processes and the integration with organic chemistry…
Proteolytic enzymes are of great medical interest because they are involved in diseases suchas cancer, inflammatory conditions and cardiovascular diseases, and as potential therapeutictargets or biomarkers for prognosis. Kallikreins are members of the serine protease familyand gained attention in recent years due to the fact that they are differentially expressed inpathological processes.…
Skin is the first barrier protection against injuries, infections and is involved in immunoregulatory mechanisms. Proteases are play roles in these physiological and pathophysiological functions including skin desquamation. This project will focus on two tissue kallikrein 5 and7 (KLK5 and KLK7) highly expressed and functional in human skin. Both are serine proteases, but KLK5 such as tryp…
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry emerge as the first line techniques for rapid identification of bacteria. In contrast to DNA-based methods, the detection of mass patterns by mass spectrometry does not require reference genome or protein sequences. Due to the reemergence of leptospirosis in non-endemic regions, it is now recognized a…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 3 | Completed research grants |
| 6 / 4 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 13 / 8 | All research grants and scholarships |
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