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Marcos Roberto de Mattos Fontes

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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Graduation in Physics at the University of São Paulo (1989), Master in Sciences (1992), and PhD (1995) in Physics by University of São Paulo; Post-doctorals at the University of Melbourne (2001) and University of Queensland (2004), both in Australia. At this moment, he is a Full Professor in Biophysics at the São Paulo State University (UNESP) - Institute of Biosciences - Botucatu/SP. He has experience in Molecular Biophysics field, including protein crystallography, bioinformatics, calorimetry and other biophysical techniques. The main research fields include animal toxins, nuclear import proteins, DNA repair proteins and other proteins with biotechnological importance. He is the head of the Department of Physics and Biophysics and head of the Structural Biology Laboratory. He was the coordinator of Applied and General Biology graduation course (4 years) and head of the Department of Physics and Biophysics by three terms. He was responsible for the third laboratory in South America able to work with protein crystallography techniques and he worked in the project responsible for the first protein solved by crystallography in South America (1995) during his PhD. He has supervised 29 MSc/PhD and over than 30 diploma thesis and already coordinated over than 20 research projects granted by FAPESP, CNPq e FINEP (Brazilian governmental research agencies). Nowadays, he is Editor of Scientific Reports (Nature group) journal and reviewer of over 20 scientific journals and was responsible for oral communications in several international conferences. He was vice-presidente and treasurer of Brazilian Society of Toxinology. He has an active role as a Scientific Consultant in the area of research and development with pharmaceutical companies and also acts as a Senior Visiting Researcher at Fiocruz-Rondônia..He already published more than 130 scientific articles in important scientific journals which were already cited over than 3400 times in other articles with H index of 32. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher
Researchers describe action of molecule that is more potent than botulinum toxin 
Articles published in Pesquisa FAPESP Magazine about the researcher:
Allies for an antidotal serum 
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Scholarships abroad
FAPESP support in numbers * Updated May 15, 2021
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications19
Citations58
Cit./Article3.1
Data from Web of Science

MAKIYAMA, RODRIGO K.; FERNANDES, CARLOS A. H.; DREYER, THIAGO R.; MODA, BRUNO S.; MATIOLI, FABIO F.; FONTES, MARCOS R. M.; MAIA, IVAN G.. Structural and thermodynamic studies of the tobacco calmodulin-like rgs-CaM protein. International Journal of Biological Macromolecules, v. 92, p. 1288-1297, . Web of Science Citations: 5. (13/17864-8, 10/03001-0)

PAVANI, RAPHAEL SOUZA; DA SILVA, MARCELO SANTOS; HENRIQUE FERNANDES, CARLOS ALEXANDRE; MORINI, FLAVIA SOUZA; ARAUJO, CHRISTIANE BEZERRA; DE MATTOS FONTES, MARCOS ROBERTO; SANT'ANNA, OSVALDO AUGUSTO; MACHADO, CARLOS RENATO; CANO, MARIA ISABEL; FRAGOSO, STENIO PERDIGAO; et al. Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi. PLoS Neglected Tropical Diseases, v. 10, n. 12, . Web of Science Citations: 5. (14/13375-5, 14/02978-0, 13/07467-1, 15/10580-0, 14/24170-5, 13/17864-8)

SALVADOR, GUILHERME H. M.; DOS SANTOS, JULIANA I.; BORGES, RAFAEL J.; FONTES, MARCOS R. M.. Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A(2)-like toxin. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1866, n. 3, p. 473-481, . Web of Science Citations: 3. (15/17286-0)

WATANABE‚ L.; SHANNON‚ J.D.; VALENTE‚ R.H.; RUCAVADO‚ A.; ALAPE-GIRÓN‚ A.; KAMIGUTI‚ A.S.; THEAKSTON‚ R.D.G.; FOX‚ J.W.; GUTIÉRREZ‚ J.M.; ARNI‚ R.K.. Amino acid sequence and crystal structure of BaP1‚ a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities. Protein Science, v. 12, n. 10, p. 2273-2281, .

SOARES‚ A.M.; FONTES‚ M.R.M.; GIGLIO‚ J.R.. Phospholipase A2 myotoxins from Bothrops snake venoms: structure-function relationship. CURRENT ORGANIC CHEMISTRY, v. 8, n. 17, p. 1677-1690, .

CARDOSO, FABIO F.; DE SOUZA, MAXIMILIA F.; OLIVEIRA, CRISTIANO L. P.; FONTES, MARCOS R. M.. In-solution structural studies involving a phospholipase A 2-like myotoxin and a natural inhibitor: Plasticity of oligomeric assembly affects mechanisms of inhibition. Biochimie, v. 181, p. 145-153, . Web of Science Citations: 0. (15/17286-0, 12/07112-6, 18/16092-5)

BOLDRINI-FRANCA, JOHARA; PINHEIRO-JUNIOR, ERNESTO LOPES; PEIGNEUR, STEVE; PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; BORGES, RAFAEL JUNQUEIRA; COSTA, TASSIA RAFAELLA; IMAI CARONE, SANTE EMMANUEL; DE MATTOS FONTES, MARCOS ROBERTO; SAMPAIO, SUELY VILELA; et al. Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. SCIENTIFIC REPORTS, v. 10, n. 1, . Web of Science Citations: 1. (15/17286-0, 15/00740-0, 18/14158-9, 17/13485-3, 11/23236-4, 16/24191-8, 14/16182-3, 17/14035-1, 16/04761-4, 15/16714-8, 15/18432-0)

CHI, JORDI; COVA, MARTA; DE LAS RIVAS, MATILDE; MEDINA, ANA; BORGES, RAFAEL JUNQUEIRA; LEIVAR, PABLO; PLANAS, ANTONI; USON, ISABEL; HURTADO-GUERRERO, RAMON; IZQUIERDO, LUIS. Plasmodium falciparum Apicomplexan-Specific Glucosamine-6-Phosphate N-Acetyltransferase Is Key for Amino Sugar Metabolism and Asexual Blood Stage Development. MBIO, v. 11, n. 5, . Web of Science Citations: 0. (16/24191-8)

CHIOATO‚ L.; WARD‚ R.J.. Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis. Toxicon, v. 42, n. 8, p. 869-883, .

SALVADOR, GUILHERME H. M.; BORGES, RAFAEL J.; EULALIO, MICAELA M. C.; DOS SANTOS, LUCILENE D.; FONTES, MARCOS R. M.. Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom. Biochimie, v. 179, p. 54-64, . Web of Science Citations: 0. (16/24191-8)

FERNANDES, CARLOS A. H.; MOREA, EDNA GICELA O.; DOS SANTOS, GABRIEL A.; DA SILVA, VITOR L.; VIEIRA, MARINA ROVERI; VIVIESCAS, MARIA ALEJANDRA; CHATAIN, JEAN; VADEL, AURELIE; SAINTOME, CAROLE; FONTES, MARCOS ROBERTO M.; et al. A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1864, n. 7, . Web of Science Citations: 0. (15/17286-0, 18/04375-2, 19/11496-3)

MEDINA, ANA; TRIVINO, JOSEP; BORGES, RAFAEL J.; MILLAN, CLAUDIA; USON, ISABEL; SAMMITO, MASSIMO D.. ALEPH: a network-oriented approach for the generation of fragment-based libraries and for structure interpretation. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 3, p. 193-208, . Web of Science Citations: 2. (17/13485-3, 16/24191-8)

BORGES, RAFAEL JUNQUEIRA; MEINDL, KATHRIN; TRIVINO, JOSEP; SAMMITO, MASSIMO; MEDINA, ANA; MILLAN, CLAUDIA; ALCORLO, MARTIN; HERMOSO, JUAN A.; FONTES, MARCOS ROBERTO DE MATTOS; USON, ISABEL. SEQUENCE SLIDER: expanding polyalanine fragments for phasing with multiple side-chain hypotheses. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 3, p. 221-237, . Web of Science Citations: 0. (16/24191-8, 17/13485-3)

CARDOSO, FABIO F.; GOMES, ANTONIEL A. S.; DREYER, THIAGO R.; CAVALCANTE, WALTER L. G.; DAL PAI, MAELI; GALLACCI, MARCIA; FONTES, MARCOS R. M.. Neutralization of a bothropic PLA(2)-like protein by caftaric acid, a novel potent inhibitor of ophidian myotoxicity. Biochimie, v. 170, p. 163-172, . Web of Science Citations: 0. (12/07112-6, 15/17286-0)

DE BARROS, ANDREA C.; TAKEDA, AGNES A. S.; DREYER, THIAGO R.; VELAZQUEZ-CAMPOY, ADRIAN; KOBE, BOSTJAN; FONTES, MARCOS R. M.. DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, v. 146, p. 87-96, . Web of Science Citations: 3. (09/14118-8, 13/24705-3)

RICHARDS, LOGAN S.; MILLAN, CLAUDIA; MIAO, JENNIFER; MARTYNOWYCZ, MICHAEL W.; SAWAYA, MICHAEL R.; GONEN, TAMIR; BORGES, RAFAEL J.; USON, ISABEL; RODRIGUEZ, JOSE A.. Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 8, p. 703-712, . Web of Science Citations: 0. (16/24191-8, 17/13485-3)

FERNANDES, CARLOS A. H.; PAZIN, WALLANCE M.; DREYER, THIAGO R.; BICEV, RENATA N.; CAVALCANTE, WALTER L. G.; FORTES-DIAS, CONSUELO L.; ITO, AMANDO S.; OLIVEIRA, CRISTIANO L. P.; FERNANDEZ, ROBERTO MORATO; FONTES, MARCOS R. M.. Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism. SCIENTIFIC REPORTS, v. 7, . Web of Science Citations: 9. (15/17286-0, 13/17864-8)

SALVADOR, GUILHERME H. M.; DOS SANTOS, JULIANA I.; LOMONTE, BRUNO; FONTES, MARCOS R. M.. Crystal structure of a phospholipase A(2) from Bothrops asper venom: Insights into a new putative ``myotoxic cluster{''}. Biochimie, v. 133, p. 95-102, . Web of Science Citations: 8. (15/17286-0, 15/24167-7)

BORGES, RAFAEL J.; CARDOSO, FABIO F.; FERNANDES, CARLOS A. H.; DREYER, THIAGO R.; DE MORAES, DELKIA S.; FLORIANO, RAFAEL S.; RODRIGUES-SIMIONI, LEA; FONTES, MARCOS R. M.. Functional and structural studies of a Phospholipase A(2)-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 1, A, p. 3199-3209, . Web of Science Citations: 10. (15/17286-0, 13/00873-4)

CARDOSO, FABIO F.; BORGES, RAFAEL J.; DREYER, THIAGO R.; SALVADOR, GUILHERME H. M.; CAVALCANTE, WALTER L. G.; DAL PAI, MAELI; GALLACCI, MARCIA; FONTES, MARCOS R. M.. Structural basis of phospholipase A(2)-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, n. 12, p. 2728-2737, . Web of Science Citations: 4. (15/17286-0, 12/07112-6)

CAVALCANTE, WALTER L. G.; NORONHA-MATOS, JOSE B.; TIMOTEO, MARIA A.; FONTES, MARCOS R. M.; GALLACCI, MARCIA; CORREIA-DE-SA, PAULO. Neuromuscular paralysis by the basic phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage. Toxicology and Applied Pharmacology, v. 334, p. 8-17, . Web of Science Citations: 5. (12/00428-8, 13/17864-8, 13/03624-5)

TOYAMA, DANIELA DE OLIVEIRA; GAETA, HENRIQUE HESSEL; TERASHIMA DE PINHO, MARCUS VINICIUS; PENA FERREIRA, MARCELO JOSE; ROMOFF, PAULETE; MATIOLI, FABIO FILIPPI; MAGRO, ANGELO JOSE; DE MATTOS FONTES, MARCOS ROBERTO; TOYAMA, MARCOS HIKARI. An Evaluation of 3-Rhamnosylquercetin, a Glycosylated Form of Quercetin, against the Myotoxic and Edematogenic Effects of sPLA(2) from Crotalus durissus terrificus. BIOMED RESEARCH INTERNATIONAL, . Web of Science Citations: 3. (11/06704-4, 13/12077-8, 12/06502-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BERNARDES, Natália Elisa. Estudos estruturais com a importina-α do fungo Neurospora crassa e sequências de localização nuclear.  121 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (12/16371-5

FERNANDES, Carlos Alexandre Henrique. Estudos estruturais com fosfolipases A2 isoladas de venenos de serpentes dos gêneros Bothrops e Crotalus.  164 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (09/10905-5

BORGES, Rafael Junqueira. Estudos estruturais com fosfolipases A2 homólogas de veneno botrópicos em presença de íons com importância funcional.  112 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (09/12155-3

JUNIOR, Carlos Roberto Natal. Estudo estrutural da interação da crotoxina e suas subunidades com membranas modelo. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (18/05090-1

BORGES, Rafael Junqueira. Structural studies of PLA2-like toxins and development of the structure solution method sequence slider. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (13/00873-4

MAGRO, Angelo José. Estudos estruturais experimentais e teóricos com proteínas do veneno da serpente Bothrops jararacussu.  85 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (04/02376-9

SANTOS, Juliana Izabel dos. Estudos estruturais com miotoxinas do tipo fosfolipases A2 homólogas do veneno de serpentes do gênero Bothrops : avanços no entendimento da relação estrutura-função.  165 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (07/59084-8

SALVADOR, Daniela Priscila Marchi. EStudos estuturais com miotoxinas Lys49-PLA2(s) nativas e complexadas com vitamina E.  127 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (03/04469-1

SALVADOR, Guilherme Henrique Marchi. Estudos estruturais com fosfolipases A2 e fosfolipases A2 homólogas isoladas no veneno de Bothrops moojeni.  80 f. Dissertação (Mestrado) -  Instituto de Biociências de Botucatu.  Universidade Estadual Paulista "Júlio de Mesquita Filho".  (10/02799-8

SOUZA, Edmarcia Elisa de. Clonagem, expressão e purificação de domínios da proteína AtRLI2 (RNase L Inhibitor), um supressor endógeno de silenciamento por RNA de Arabidopis thaliana, visando estudos estruturais.  71 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (07/52895-0

TAKEDA, Agnes Alessandra Sekijima. Estudos estruturais com a importina.  89 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (04/04659-8

BARROS, Andréa Coelho de. Estudos estruturais com a importina-α de mamíferos e peptídeos de sequências de localização nuclear (NLS).  91 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (09/11510-4

FERNANDES, Carlos Alexandre Henrique. Estudos estruturais e filogenéticos com fosfolipases e serino proteases de venenos de serpentes botrópicas nativas e quimicamente modificadas.  98 f. Dissertação (Mestrado) -  Instituto de Biociências de Botucatu.  Universidade Estadual Paulista "Júlio de Mesquita Filho".  Botucatu.  (07/51417-8

MAGRO, Angelo José. Determinação estrutural das fosfolipases homólogas BnSP-7 e BnSP-6 : considerações a respeito de suas estruturas quaternárias e mecanismos de inibição.  50 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (01/12053-4

BERNARDES, Natália Elisa. Estudos estruturais com a importina-α do fungo Neurospora crassa e peptídeos de sequências de localização nuclear (NLS) de proteínas relacionadas ao metabolismo de fungos. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (14/10289-0

BARROS, Andréa Coelho de. Estudos estruturais com a importina-σ de mamíferos e peptídeos de sequências de localização nuclear (NLS) de proteínas envolvidas no reparo de DNA. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (11/09905-0

SALVADOR, Guilherme Henrique Marchi. Estudos estruturais de complexos entre fosfolipases A2 homólogas isoladas do veneno de Bothrops moojeni e inibidores da atividade miotóxica. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (12/10830-8

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