Graduation in Physics at the University of São Paulo (1989), Master in Sciences (1992), and PhD (1995) in Physics by University of São Paulo; Post-doctorals at the University of Melbourne (2001) and University of Queensland (2004), both in Australia. At this moment, he is a Full Professor in Biophysics at the São Paulo State University (UNESP) - Institute of Biosciences - Botucatu/SP. He is currently working as a part-time Senior Visiting Researcher at IEAMAR/UNESP (Institute for Advanced Studies of the Sea) - São Vicente/SP. He has experience in Molecular Biophysics field, including protein crystallography, bioinformatics, calorimetry and other biophysical techniques. The main research fields include animal toxins, nuclear import proteins, DNA repair proteins and other proteins with biotechnological importance. He is the head of the Department of Physics and Biophysics and head of the Structural Biology Laboratory. He was the coordinator of Applied and General Biology graduation course (4 years) and head of the Department of Physics and Biophysics by three terms. He was responsible for the third laboratory in South America able to work with protein crystallography techniques and he worked in the project responsible for the first protein solved by crystallography in South America (1995) during his PhD. He has supervised 33 MSc/PhD and over than 30 diploma thesis and already coordinated over than 20 research projects granted by FAPESP, CNPq e FINEP (Brazilian governmental research agencies). Nowadays, he is Editor of Scientific Reports (Nature group) journal and reviewer of over 20 scientific journals and was responsible for oral communications in several international conferences. He was vice-presidente and treasurer of Brazilian Society of Toxinology. He was Senior Visiting Researcher at Fiocruz-Rondônia (2019-2022). He already published aproximatly 150 scientific articles in important scientific journals which were already cited over than 3600 times in other articles with H index of 34. (Source: Lattes Curriculum)
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Neglected tropical diseases (NTD) are defined by World Health Organization (WHO) as "a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries - affect more than one billion people and cost developing economies billions of dollars every year. Populations living in poverty, without adequate sanitation and in close contact with infectious …
The high pressure liquid chromatography (HPLC) system is an equipment used for purification / separation of biological macromolecules. Several chromatographic techniques may be used, including size, charge, affinity, hydrophobicity, etc. (AU)
Envenoming caused by snakebites is considered a public health problem in many tropical and subtropical countries and has recently been included in the list of Neglected Tropical Diseases by the World Health Organization. In Latin America, the majority of ophidic accidents are caused by snakes from Bothrops and Crotalus genus. One of the main complications regarding bothropic envenomation …
The scientific collaboration between Prof. Bostjan Kobe and Prof. Fontes started during his post-doctoral at the University of Melbourne - Australia in May/1999. Since then, Prof. Fontes had the opportunity to return to Prof Bostjan's laboratory twice, and Prof. Bostjan also came to Brazil (Botucatu) twice. This long-term interaction resulted in the publication of 10 papers in journals …
(Only some records are available in English at this moment)
Snakebites are a worldwide public health problem, considered by the World Health Organization as a neglected tropical disease, which may lead to permanent debilitating sequelae and, eventually, to death. In Brazil, the Crotalus snake genus (popularly known as rattlesnakes) promotes the highest fatality rate by snakebites. The toxic effects promoted by crotalic venom are due to the action …
Snakebites are a public health problem, concerning tropical and subtropical regions, rural and poor areas of Latin America, Africa, Asia and Oceania. In Brazil, Bothrops and Crotalus genera account for about 98% of reported snakebites. Bothropic envenomation is characterized by intense local myonecrosis (and other local effects) inefficiently neutralized by antivenom, which can induce sli…
(Only some records are available in English at this moment)
The quantitative study of the protein-binding interaction has been shown to be essential for the study of nuclear import mechanisms. Particularly, in the so-called classical nuclear import pathway these data are essential, because import±-± (Imp±) is coupled to cargo proteins to be transported to the nucleus from nuclear localization sequence (NLS) recognition. Imp± are classified into di…
Crotoxin (CTX) is the most abundant toxin present in the venom of Crotalus durissus terrificus, accounting for about 60 per cent of the dry venom weight of this snake. CTX has neurotoxic, myotoxic and coagulant activities and it is the main responsible for the high number of death by ophidian accidents caused by snakes of the genus Crotalus. In addition to those characteristics, it was di…
(Only some records are available in English at this moment)
Most ophidian accidents in Latin America are caused by Bothrops genus snakes. Myonecrosis, which is not efficiently neutralized by antivenom treatment, is one of the consequences of these accidents. Myotoxic phospholipases A2 (PLA2s) and PLA2-like proteins are usually abundant in bothropic venom and one of the main responsible for muscular necrosis. These proteins are myotoxic by breaking…
Importin-alpha (Impa) is a protein that mediates nuclear import via recognition of nuclear localization sequences (NLSs) in the macromolecule that will be transported. The concave surface of Impa contains conserved residues that form two NLS binding sites known as major and minor NLS binding sites. To better understand NLS recognition and gain information about the fungal nuclear import p…
The majority of ophidian accidents in Brazil are caused by Bothrops genus snakes. Myonecrosis, which is not efficiently neutralized by administration of antiophidian serum, is one of the consequences of these accidents. Myotoxic phospholipases A2 (PLA2s) are the main component of bothropic venom and one of the main responsible for muscular necrosis. These toxins are classified as PLA2s or…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 16 / 10 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 58 / 33 | Completed scholarships in Brazil |
| 6 / 4 | Completed scholarships abroad |
| 86 / 53 | All research grants and scholarships |
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