José Carlos Farias Alves Filho

• Abstract

  Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus from the Herpesviridae family, widely disseminated in the human population and capable of establishing a latent infection in sensory neurons following primary infection. Although classically associated with mucocutaneous manifestations such as cold sores, HSV-1 can also affect the central nervous system, leading to severe …

  Molecular Mechanisms Underlying Regulatory T Cell Activation by HSV-1 and Its Impact During the Infection, AP.R

• Abstract

  This proposal aims to acquire essential equipment to modernize the animal facilities of the Center for the Breeding of Special Mice (CCCE) and the new Center for Research in Biomedical Sciences (CPCBio), both part of the Ribeirão Preto Medical School at the University of São Paulo (FMRP-USP). Proper structuring of these facilities is crucial to ensure the maintenance of mice under specifi…

  Animal Facilities and Biosafety - Line "A", "Modernization of the Animal Facility Infrastructure at the Ribeirão Preto Medical School of the University of São Paulo, AP.PI

• Abstract

  The present FAPESP/BAYLAT workshop aims to bring together researchers from Brazil and Germany interested in immunology. This workshop will provide a platform for early career scientists, including PhD students and Postdocs, to present their immunology research in a bi-national context. Discussions, guided by leading experts, will explore the diverse world of T cell heterogeneity and its c…

  T cell heterogeneity and their Function in Health and Disease, AO.R

(Only some records are available in English at this moment)

• FAPESP Week France, AR.EXT

• Abstract

  Acontecerá a nona edição do Simpósio no mês de Junho de 2024, durante os dias 12, 13 e 14 de junho, denominado IX International Symposium on Inflammatory Diseases - INFLAMMA IX. Trata-se de uma congregação científica com o objetivo de promover aprendizado aos participantes, através de discussões que incentivem a investigação e desenvolvimento do tratamento de doenças inflamatórias. (AU)

  IX International Symposium on Inflammatory Diseases - INFLAMMA IX, AO.R

• Abstract

  The proposed application aims to consolidate collaboration between two well-established research groups at the University of São Paulo, Brazil, and the University Medicine of the Johannes-Gutenberg University Mainz, Germany. Here, we propose visits and exchanges of faculty staff, post-docs, and Ph.D. students, which will allow us to develop qualitatively ongoing projects, provide training…

  Understanding the molecular regulation of Th17 and regulatory T cells in infections and autoimmune diseases, AP.R

(Only some records are available in English at this moment)

• Abstract

  Herpes simplex type 1 (HSV-1) is a virus of the Herpesviridae family and represents a significant public health problem due to its high prevalence, ability to establish latency in sensory neurons, and recurrence of painful lesions. Although frequently associated with mucocutaneous manifestations, such as cold sores, HSV-1 can also affect the central nervous system, resulting in serious co…

  Mechanisms of Immunopathology Control by Tregs during HSV-1 Infection, BP.DD

• Abstract

  Herpes Simplex Virus type 1 (HSV-1) is a double-stranded DNA pathogen that initiates infection in keratinocytes of the skin, mucosa, or genitals, where it replicates extensively, leading to cell lysis and vesicular lesion formation. Subsequently, the virus migrates to sensory ganglia, establishing latent infection. The immune response to HSV-1 relies on a delicate balance between antivira…

  Importance of STING signaling in the modulation of regulatory T lymphocytes by HSV-1 in vivo, BP.MS

• Abstract

  Regulatory T cells (Treg) are a subset of CD4+ T lymphocytes responsible for maintaining immune tolerance. In a tumor context, Tregs contribute to the establishment of an immunosuppressive environment that impairs the recognition and elimination of cancer cells by the immune system. This process contributes to immune evasion and tumor growth, resulting in a worse prognosis for cancer. ERK…

  The Role of ERK5 Signaling in Regulatory T Cells (Treg) in Colorectal Cancer Progression, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Psoriasis is a systemic inflammatory disease, primarily affecting the skin. It is characterized by hyperactivation and high proliferation of keratinocytes, along with an increased infiltration of inflammatory cells in the skin. Despite recent advancements in understanding the pathophysiology and treatment of the disease, the mechanisms of disease development and chronicity remain poorly u…

  Participation of the NOD2/RIPK2 signaling pathway in the pathophysiology of psoriasis., BP.MS

• Abstract

  O HSV-1 pode persistir no hospedeiro, escapando do sistema imunológico através de infecções latentes nos neurônios. Este estudo visa estabelecer um modelo murino de infecção com HSV1 para analisar as alterações metabólicas em linfócitos, especialmente Tregs. Serão utilizados camundongos WT e transgênicos, com a indução do modelo por diferentes protocolos de inoculação. Após coleta de pele…

  Metabolic changes in lymphocytes in the face of viral infection, BP.TT

• Abstract

  O reconhecimento diferencial de patógenos versus de microrganismos não patogênicos é essencial para garantir respostas imunes rápidas e efetivas que limitam a replicação de micróbios patogênicos em células e tecidos. Esse reconhecimento diferencial se faz por receptores localizados no citoplasma das células do sistema imune inato. Entre esses receptores, encontra-se a família de proteínas…

  Mechanisms and consequences of the activation of cytoplasmic receptors by intracellular pathogens, BP.TT

(Only some records are available in English at this moment)