graduation at Medicina from Universidade de Brasília (1973) and doctorate at Physiology from Universidade de São Paulo (1981). He is currently pesquisador responsável at Instituto do Coração do Hospital das Clinicas da FMUSP. Has experience in Medicine, acting on the following subjects: ldl, coronary artery disease, chylomicron metabolism, chylomicron and lipoproteina(a). (Source: Lattes Curriculum)
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In world pioneer studies, we showed nanoparticles (LDE) similar to the lipid structure of low-density lipoprotein (LDL) can concentrate anti-cancer agents, such as paclitaxel, etoposide, and methotrexate, in neoplastic and inflamed tissues. Using LDE as carrier, the toxicity of those agents was drastically reduced, whereas the pharmacologic actions were enhanced. The near-absence of toxic…
The Liquid Scintillation Counter is key equipment in our Laboratory to carry out the studies on HDL metabolism, lipid transfer, pharmacokinetics and biodistribution, cholesterol efflux and cellular uptake of drugs and nanoparticles, proposed in the sub-projects of this Thematic Project. (AU)
In previous and pioneer studies, we showed that, upon injection in the blood circulation, non-protein lipid nanoemulsions (LDE) with composition resembling low-density lipoprotein (LDL) have the ability to carry chemotherapeutic agents and concentrate them in malignant tumors or inflammation sites. By using LDE as vehicle, toxicity of those drugs was pronouncedly reduced without loss of a…
Acute Myocardial Infarction (AMI), the main death cause in the Western world and in Brazil, is accompanied by cardiac remodeling that frequently results in cardiac failure. The inflammatory process that occurs in AMI is the main causal fator of cardiac remodeling. The aim is to investigate the effects of metothrexate (MTX), an imunossupressor and anti-proliferative agent, on the model of…
(Only some records are available in English at this moment)
The clinical treatment of coronary artery disease (CAD) is still restricted to interventions on risk factors, reflected in the administration of statins and antiplatelet. Analyzing the strong proliferative-inflammatory component of the disease, a treatment strategy based on antiproliferative drugs such as those used in cancer treatment, can be a very promising therapeutic route, directed …
| 2 / 2 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 15 / 2 | Completed scholarships in Brazil |
| 32 / 13 | All research grants and scholarships |
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CV Lattes
ORCID