Marinilce Fagundes dos Santos

• XXI Congress of the Brazilian Society for Cell Biology, AO.R

• Abstract

  Using in vitro and in vivo systems, we have studied the role of chronic hyperglycemia present in Diabetes Mellitus (DM) on migration and function of fibroblasts. Impaired wound healing is a common complication of DM and contributes to the formation of chronic wounds, which reduce patient's life quality and entail enormous costs for the public health system. We demonstrated deleterious eff…

  Glycotoxicity, oxidative stress and tissue senescence: role of microRNAs and effects on wound healing, AP.R

• Abstract

  Deficient wound healing in diabetic patients is one of the most common complications of hyperglycemia (HG) and is associated with microangiopathy, neuropathy and fibroblasts dysfunction. Some studies using fibroblasts from diabetic patients or fibroblasts cultured under conditions that simulate HG showed changes in cell proliferation and ECM protein synthesis. Few studies, however, have a…

  Hyperglycemia and fibroblast migration in 3-D extracellular matrices, matrix composition and remodeling - potential roles of microRNAs 31, 196a e 29b, AP.R

(Only some records are available in English at this moment)

• Abstract

  Diabetes mellitus (DM) is characterized by chronic hyperglycemia (HG), in a long-term is associated mainly with complications of oxidative stress and glycation. One of the common complications of diabetes is chronic wound; addition to impairment of the vascular system, there are studies suggesting the involvement of specific functions of fibroblasts, important cells in the healing process…

  Effects of high glucose concentration on migration of periodontal fibroblasts: potential regulation of Rho GTPases by micro RNAs, BP.DD

• Abstract

  Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, which damages different cells and tissues. A common long term complication of DM is wound healing impairment, a problem that significantly reduces life quality for the patients. The main mechanisms involved in DM complications are oxidative stress and extracellular matrix (ECM) protein glycation. Glycati…

  ROLE OF OXIDATIVE STRESS AND EXTRACELLULAR MATRIX GLYCATION ON MIGRATION OF DIABETIC SKIN FIBROBLASTS, BP.DR

• Abstract

  During epithelial tumor invasion, proteins that regulate cell-cell interactions, the loss of apical-basal polarization and increased cell motility are differentially expressed. This process is known as epithelial-mesenchymal transition (EMT), and is partially regulated by small molecular weight GTPases from the Rho family (from Ras-Homology). Although much is known about the role of Rho …

  MicroRNAs and tumor invasion: involvement of Rho GTPases, BP.PD

(Only some records are available in English at this moment)