CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduation at Medicina from Universidade Federal de São Paulo (1972), master (Ms) in Microbiology, Immunology and Parasitology at Universidade Federal de São Paulo (1978) and PhD in Immunology at Institute of Biomedical Sciences, Universidade de São Paulo (1982). Post-doctoral as New York University (NY-UAS) and Institute Pasteur (Paris-France). Full professor since 2003 at ICB-USP. President of the Brazilian Society of Immunology (2004-2006). Has experience in Immunology, focusing on Celular Immunology, Inflammation and Immunity, acting on experimental models of human diseases like infections by viruses, bacteria, protozoan and fungi, viruses as well in asthma models. (Source: Lattes Curriculum)
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Asthma is considered a pulmonary allergic inflammatory syndrome, which, in its classic form, is associated with uncontrolled activity of CD4-positive cells called T helper 2 (Th2). Current therapies for asthma are mostly symptomatic, but specific immunotherapy (IT) consisting of continuous administration of increasing doses of allergen is potentially curative. The inconveniences of IT are…
A specific subset of CD4 T cells, namely T follicular helper (Tfh) cells, characterized by expression of transcription factor Bcl6, are unique in their ability to access the B cell follicle and drive germinal center (GC) reactions leading to isotype switching, affinity maturation, and production of high affinity antibodies and memory B cells. Therefore, in addition to the influence of "cl…
Allergy prevalence and severity of asthma are increasing worldwide. Asthma is a chronic lung inflammatory syndrome and its classical phenotype is associated with deregulated activity of Thelper2 (Th2) cells. The current therapies to asthmatic patients are basically symptomatic and not therapeutic. Murine models have been developed to study asthma mechanisms and ovalbumin (OVA) is the most…
Allergic asthma can vanish over time either spontaneously or induced by allergen specific immunotherapy. In mice with established airway allergic inflammation, chronic intranasal allergen challenges decreases progressively airway allergic inflammation. Here we compared the contribution of different regulatory pathways that could be associated with this phenomenon, known as local inhalatio…
(Only some records are available in English at this moment)
The prevalence and severity of allergies and asthma in particular are increasing worldwide. Currently, asthma is considered a chronic inflammatory pulmonary syndrome in its classic form is associated with the uncontrolled T helper cell 2 (Th2) activities . Murine models have been developed to study the mechanisms of asthma and ovalbumin (OVA) is the most commonly used allergen. In previo…
The prevalence and severity of allergy, including asthma, are on the rise worldwide. At present, asthma is considered a lung chronic inflammatory disease and its classic form is associated with uncontrolled T helper (Th)2 cells activity. Murine models have been developed to investigate mechanisms of asthma, and ovalbumin (OVA) is the most commonly used allergen. However, this protein is a…
The prevalence and severity of asthma has been increasing worldwide. Asthma is considered a chronic pulmonary inflammatory syndrome and its classical form is associated with deregulated Th2 type immunity. Murine models have been developed to study asthma mechanisms, and ovalbumin (OVA) is the most commonly used antigen. However, the OVA model does not represent the scenario that asthmatic…
(Only some records are available in English at this moment)
T Follicular helper cells (Tfh) are a population of CD4+ T lymphocytes, essential for the generation of high affinity humoral response, since they have a unique ability to interact with B cells and promote germinal centers (CG).In CG, the interaction of Tfh with B cells leads to immunoglobulin isotype exchange, affinity maturation, and generation of memory B cells. Therefore, understandin…
Allergic responses are considered as cellular processes originated basically from the immune system. However, the dramatic rise in the prevalence of such disorders suggests a more complex phenomenon. Recent clinical and experimental evidences implicate both the epithelium and sensitive neurons, through C type fibers, directly in the development of allergic inflammation. Nevertheless, the …
| 1 / 1 | Ongoing grants |
| 20 / 11 | Completed research grants |
| 26 / 6 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 50 / 20 | All research grants and scholarships |
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