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Célia Regina da Silva Garcia

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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Chemistry from the Federal University of Rio de Janeiro (1981), Master in Biophysics, UFRJ (1987), and Doctorate in Biophysics, (1990) UFRJ with sandwich Doctorate and internships: Whitehead Institute, MIT in Boston (USA), University of Pacific, California (USA). Post-doctorate: King's College (England) and Babraham Institute in Cambridge (England) and at the National Institute of Bioscience and Human Technology in Tsukuba (Japan). Full Professor at USP (from 2001) and the Department of Clinical and Toxicological Analysis - FCF- University of São Paulo (2018-). Visiting Professor in the Department of Pathology, NYU (New York University), New York, USA (2004-2005) Adjunct Professor at Rutgers, The State University of New Jersey University (USA). Our research aims to investigate how chemical signals in the host-pathogen relationship modulate the malaria parasite cycle. The laboratory's main research lines include Screening of synthetic and natural compounds with a focus on the development of new drugs for the treatment of malaria. Membrane receptors of the GPCR (G protein-coupled receptor) type make up about 50% of the drug target in the pharmaceutical industry. We investigated Plasmodium falciparum GPCRs using a high throughput screening and cell imaging approach. For her work in malaria, she is a Fellow of the John Simon Guggenheim Memorial Foundation, a speaker at several international and national congresses. Associate Editor of Current Research in Microbial Sciences and a member of the editorial board of the journals: Molecular and Biochemical Parasitology, Methods X, Current Opinion in Microbiology, Current Topics in Medicinal Chemistry, Cellular and Molecular Life Sciences. Member of the CNPq editorial committee (2013-2018). Consultant to several national and international agencies: Welcome Trust, European Research Council, US-Israel Binational Science Foundation, Medical Research Council, Ministry of Science and Technology (MCT) in Portugal (2000 to 2002). Prof. Garcia coordinated the USP Research Center (NUSCEP) Cell signaling in the pathogen-host interaction (2012-2018). She is a full member of the Brazilian Academy of Sciences (2018), the World Academy of Sciences (TWAS - 2020), and the São Paulo State Academy (ACIESP) (2020). Fellow of the American Society for Cell Biology. President of the International Affairs Committee of the American Society for Cell Biology (ASCB) and advisor and collaborator of the Dean of Graduate Studies at the University of São Paulo (2019-). (Source: Lattes Curriculum)

Research grants
Scholarships in Brazil
Scholarships abroad
FAPESP support in numbers * Updated October 24, 2020
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (29)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications25
Citations261
Cit./Article10.4
Data from Web of Science

LEE, ANDREW H.; DHINGRA, SATISH K.; LEWIS, IAN A.; SINGH, MANEESH K.; SIRIWARDANA, AMILA; DALAL, SEEMA; RUBIANO, KELLY; KLEIN, MATTHIAS S.; BASKA, KATELYNN S.; KRISHNA, SANJEEV; et al. Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. SCIENTIFIC REPORTS, v. 8, . Web of Science Citations: 3. (11/51295-5)

SCARPELLI PEREIRA, PEDRO H.; CURRA, CHIARA; GARCIA, CELIA R. S.. Ubiquitin Proteasome System as a Potential Drug Target for Malaria. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 18, n. 5, p. 315-320, . Web of Science Citations: 6. (11/51295-5)

ANA CAROLINA RENNÓ SODERO; BÁRBARA ABRAHIM-VIEIRA; PEDRO HENRIQUE MONTEIRO TORRES; PEDRO GERALDO PASCUTTI; CÉLIA RS GARCIA; VITOR FRANCISCO FERREIRA; DAVID RODRIGUES DA ROCHA; SABRINA BAPTISTA FERREIRA; FLORIANO PAES SILVA JR. Insights into cytochrome bc(1) complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do Instituto Oswaldo Cruz, v. 112, n. 4, p. 299-308, . Web of Science Citations: 2. (11/51295-5)

ANA CAROLINA RENNÓ SODERO; BÁRBARA ABRAHIM-VIEIRA; PEDRO HENRIQUE MONTEIRO TORRES; PEDRO GERALDO PASCUTTI; CÉLIA RS GARCIA; VITOR FRANCISCO FERREIRA; DAVID RODRIGUES DA ROCHA; SABRINA BAPTISTA FERREIRA; FLORIANO PAES SILVA JR. Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do Instituto Oswaldo Cruz, v. 112, n. 4, p. -, . (11/51295-5)

KOYAMA, FERNANDA C.; CARVALHO, THAIS L. G.; ALVES, EDUARDO; DA SILVA, HENRIQUE B.; DE AZEVEDO, MAURO F.; HEMERLY, ADRIANA S.; GARCIA, CELIA R. S.. The Structurally Related Auxin and Melatonin Tryptophan-Derivatives and their Roles in Arabidopsis thaliana and in the Human Malaria Parasite Plasmodium falciparum. Journal of Eukaryotic Microbiology, v. 60, n. 6, p. 646-651, . Web of Science Citations: 23. (11/51295-5)

ALVES, EDUARDO; IGLESIAS, BERNARDO A.; DEDA, DAIANA K.; BUDU, ALEXANDRE; MATIAS, TIAGO A.; BUENO, VANIA B.; MALUF, FERNANDO V.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS; CATALANI, LUIZ H.; et al. Encapsulation of metalloporphyrins improves their capacity to block the viability of the human malaria parasite Plasmodium falciparum. Nanomedicine-Nanotechnology Biology and Medicine, v. 11, n. 2, p. 351-358, . Web of Science Citations: 8. (11/51295-5)

ALVES, EDUARDO; BARTLETT, PAULA J.; GARCIA, CELIA R. S.; THOMAS, ANDREW P.. Melatonin and IP3-induced Ca2+ Release from Intracellular Stores in the Malaria Parasite Plasmodium falciparum within Infected Red Blood Cells. Journal of Biological Chemistry, v. 286, n. 7, p. 5905-5912, . Web of Science Citations: 60. (07/52924-0)

GAZARINI, MARCOS L.; THOMAS, ANDREW P.; POZZAN, TULLIO; GARCIA, CÉLIA R. S.. Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. JOURNAL OF CELL BIOLOGY, v. 161, n. 1, p. 103-110, . (98/00410-2)

BERALDO, FLÁVIO H.; ALMEIDA, FABIANA M.; SILVA, ALINE M. DA; GARCIA, CÉLIA R. S.. Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle. JOURNAL OF CELL BIOLOGY, v. 170, n. 4, p. 551-557, . (02/06194-7)

MADEIRA, LUCIANA; GALANTE, PEDRO A. F.; BUDU, ALEXANDRE; AZEVEDO, MAURO F.; MALNIC, BETTINA; GARCIA, CELIA R. S.. Genome-Wide Detection of Serpentine Receptor-Like Proteins in Malaria Parasites. PLoS One, v. 3, n. 3, . Web of Science Citations: 24. (07/52924-0)

FARIAS, SHIRLEY L.; GAZARINI, MARCOS L.; MELO, ROBSON L.; HIRATA, IZAURA Y.; JULIANO, MARIA A.; JULIANO, LUIZ; GARCIA, CÉLIA R. S.. Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium. Molecular and Biochemical Parasitology, v. 141, n. 1, p. 71-79, . (02/06194-7, 03/09994-7)

DEDA, DAIANA K.; IGLESIAS, BERNARDO A.; ALVES, EDUARDO; ARAKI, KOITI; GARCIA, CELIA R. S.. Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents. Molecules, v. 25, n. 9, . Web of Science Citations: 0. (17/08684-7, 18/07177-7, 18/21489-1)

SIDEN-KIAMOS, INGA; PACE, TOMASINO; KLONIZAKIS, ANTONIOS; NARDINI, MARCO; GARCIA, CELIA R. S.; CURRA, CHIARA. Identification of Plasmodium berghei Oocyst Rupture Protein 2 (ORP2) domains involved in sporozoite egress from the oocyst. International Journal for Parasitology, v. 48, n. 14, p. 1127-1136, . Web of Science Citations: 2. (16/03952-0)

CAMPOS AGUIAR, ANNA CAROLINE; PANCIERA, MICHELE; SIMAO DOS SANTOS, ERIC FRANCISCO; SINGH, MANEESH KUMAR; GARCIA, MARIANA LOPES; DE SOUZA, GUILHERME EDUARDO; NAKABASHI, MYNA; COSTA, JOSE LUIZ; GARCIA, CELIA R. S.; OLIVA, GLAUCIUS; et al. Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity. Journal of Medicinal Chemistry, v. 61, n. 13, p. 5547-5568, . Web of Science Citations: 7. (11/51295-5, 15/18192-9, 13/07600-3, 13/25613-5, 14/25770-6)

CRUZ, LAURA N.; WU, YANG; ULRICH, HENNING; CRAIG, ALISTER G.; GARCIA, CELIA R. S.. Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1860, n. 7, p. 1489-1497, . Web of Science Citations: 9. (11/51295-5)

SCHUCK, DESIREE C.; JORDAO, ALESSANDRO K.; NAKABASHI, MYNA; CUNHA, ANNA C.; FERREIRA, VITOR F.; GARCIA, CELIA R. S.. Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 78, p. 375-382, . Web of Science Citations: 28. (11/51295-5)

SCHUCK, DESIREE CIGARAN; RIBEIRO, RAMIRA YURI; NERY, ARTHUR A.; ULRICH, HENNING; GARCIA, CELIA R. S.. Flow Cytometry as a Tool for Analyzing Changes in Plasmodium falciparum Cell Cycle Following Treatment with Indol Compounds. Cytometry Part A, v. 79A, n. 11, p. 959-964, . Web of Science Citations: 18. (07/52924-0)

SCHUCK, DESIREE C.; FERREIRA, SABRINA B.; CRUZ, LAURA N.; DA ROCHA, DAVID R.; MORAES, MIRIAM S.; NAKABASHI, MYNA; ROSENTHAL, PHILIP J.; FERREIRA, VITOR F.; GARCIA, CELIA R. S.. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malaria Journal, v. 12, . Web of Science Citations: 25. (07/52924-0)

WU, YANG; CRUZ, LAURA N.; SZESTAK, TADGE; LAING, GAVIN; MOLYNEUX, GEMMA R.; GARCIA, CELIA R. S.; CRAIG, ALISTER G.. An external sensing system in Plasmodium falciparum-infected erythrocytes. Malaria Journal, v. 15, . Web of Science Citations: 4. (11/51295-5)

ALVES, EDUARDO; MALUF, FERNANDO V.; BUENO, VANIA B.; GUIDO, RAFAEL V. C.; OLIVA, GLAUCIUS; SINGH, MANEESH; SCARPELLI, PEDRO; COSTA, FAHYME; SARTORELLO, ROBSON; CATALANI, LUIZ H.; et al. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2 alpha) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 6. (11/51295-5, 13/07600-3, 11/21442-6)

GONCALVES, FLAVIA; DE MORAES, MIRIAM SANTOS; FERREIRA, LORRAINE BRAGA; OLIVEIRA CARREIRA, ANA CLAUDIA; KOSSUGUE, PATRICIA MAYUMI; CIDREIRA BOARO, LETICIA CRISTINA; BENTINI, RICARDO; DA SILVA GARCIA, CELIA REGINA; SOGAYAR, MARI CLEIDE; ARANA-CHAVEZ, VICTOR ELIAS; et al. Combination of Bioactive Polymeric Membranes and Stem Cells for Periodontal Regeneration: In Vitro and In Vivo Analyses. PLoS One, v. 11, n. 3, . Web of Science Citations: 7. (10/17698-2, 11/51295-5, 11/21442-6)

AGUIAR, ANNA CAROLINE; DE SOUSA, LORENA R. F.; GARCIA, CELIA R. S.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.. New Molecular Targets and Strategies for Antimalarial Discovery. Current Medicinal Chemistry, v. 26, n. 23, p. 4380-4402, . Web of Science Citations: 6. (11/51295-5, 13/07600-3)

SCARPELLI, PEDRO H.; TESSARIN-ALMEIDA, GIULLIANA; VICOSO, KENIA LOPES; LIMA, WANIA REZENDE; BORGES-PEREIRA, LUCAS; MEISSNER, KAMILA ANNA; WRENGER, CARSTEN; RAFAELLO, ANNA; RIZZUTO, ROSARIO; POZZAN, TULLIO; et al. Melatonin activates FIS1, DYN1, and DYN2 Plasmodium falciparum related-genes for mitochondria fission: Mitoemerald-GFP as a tool to visualize mitochondria structure. Journal of Pineal Research, v. 66, n. 2, . Web of Science Citations: 4. (11/51295-5, 14/14347-5, 15/26722-8, 12/12807-3)

LIMA, WANIA REZENDE; MARTINS, DAVID CORREA; PARREIRA, KLEBER SIMONIO; SCARPELLI, PEDRO; DE MORAES, MIRIAM SANTOS; TOPALIS, PANTELIS; HASHIMOTO, RONALDO FUMIO; GARCIA, CELIA R. S.. Genome-wide analysis of the human malaria parasite Plasmodium falciparum transcription factor PfNF-YB shows interaction with a CCAAT motif. ONCOTARGET, v. 8, n. 69, p. 113987-114001, . Web of Science Citations: 1. (11/51295-5, 11/50761-2, 15/01587-0)

GARCIA, CELIA R. S.; ALVES, EDUARDO; PEREIRA, PEDRO H. S.; BARTLETT, PAULA J.; THOMAS, ANDREW P.; MIKOSHIBA, KATSUHIKO; PLATTNER, HELMUT; SIBLEY, L. DAVID. InsP(3) Signaling in Apicomplexan Parasites. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 17, n. 19, p. 2158-2165, . Web of Science Citations: 7. (11/51295-5)

KOYAMA, FERNANDA C.; AZEVEDO, MAURO F.; BUDU, ALEXANDRE; CHAKRABARTI, DEBOPAM; GARCIA, CELIA R. S.. Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 12, p. 22320-22330, . Web of Science Citations: 5. (11/51295-5)

BORGES-PEREIRA, LUCAS; MEISSNER, KAMILA ANNA; WRENGER, CARSTEN; GARCIA, CELIA R. S.. Plasmodium falciparum GFP-E-NTPDase expression at the intraerythrocytic stages and its inhibition blocks the development of the human malaria parasite. PURINERGIC SIGNALLING, v. 13, n. 3, p. 267-277, . Web of Science Citations: 2. (11/51295-5, 13/10288-1, 15/26722-8, 12/12807-3, 10/51593-3)

MORAES, MIRIAM S.; BUDU, ALEXANDRE; SINGH, MANEESH K.; BORGES-PEREIRA, LUCAS; LEVANO-GARCIA, JULIO; CURRA, CHIARA; PICCI, LEONARDO; PACE, TOMASINO; PONZI, MARTA; POZZAN, TULLIO; et al. Plasmodium falciparum GPCRlike receptor SR25 mediates extracellular K+ sensing coupled to Ca2+ signaling and stress survival. SCIENTIFIC REPORTS, v. 7, . Web of Science Citations: 4. (11/51295-5)

DIAS, BARBARA K. M.; NAKABASHI, MYNA; ALVES, MARINA RANGEL RODRIGUES; PORTELLA, DANIELLE PAGLIAMINUTO; DOS SANTOS, BENEDITO MATHEUS; ALMEIDA, FAHYME COSTA DA SILVA; RIBEIRO, RAMIRA YURI; SCHUCK, DESIREE C.; JORDAO, ALESSANDRO KAPPEL; GARCIA, CELIA R. S.. ThePlasmodium falciparumeIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle. Journal of Pineal Research, . Web of Science Citations: 0. (17/08684-7, 18/07177-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BAGNARESI, Piero. Inter-relação do ritmo e da ação de drogas antimaláricas na infecção da malária de roedores. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (03/08611-7

Patent applications

PROCESSO DE OBTENÇÃO DE MICRO E NANOCÁPSULAS POLIMÉRICAS BIOCOMPATÍVEIS, MICRO E NANOCÁPSULAS POLIMÉRICAS BIOCOMPATÍVEIS E SEU USO COMO ANTIMALÁRICO BR1020140214798 - Universidade de São Paulo (USP). Koiti Araki; Célia Regina da Silva Garcia; Luiz Henrique Catalani; Daiana Kotra Deda Nogueira; Eduardo Alves dos Santos; Bernardo Almeida Iglesias - August 2014, 29

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180093452 - Universidade de São Paulo (USP). Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - May 2018, 08

PHARMACEUTICAL COMPOSITION, DRUG SCREENING METHOD AND METHOD FOR TREATING MALARIA CN200980139052 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Célia Regina Da Silva Garcia; Bettina Malnic; Luciana Madeira Da Silva; Pedro Alexandre Favoretto Galante - October 2009, 02

PHARMACEUTICAL COMPOSITION, DRUG SCREENING METHOD AND METHOD FOR TREATING MALARIA PCT/BR2009/000331 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Célia Regina Da Silva Garcia; Bettina Malnic; Luciana Madeira Da Silva; Pedro Alexandre Favoretto Galante - October 2009, 02

COMPOSIÇÃO FARMACÊUTICA, MÉTODO DE TRIAGEM DE DROGAS E MÉTODO DE TRATAMENTO PARA MALÁRIA PI0804314-0 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Célia Regina Da Silva Garcia; Bettina Malnic; Luciana Madeira Da Silva; Pedro Alexandre Favoretto Galante - October 2008, 03

PHARMACEUTICAL COMPOSITION, DRUG SCREENING METHOD AND METHOD FOR TREATING MALARIA US13/119,707 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Célia Regina Da Silva Garcia; Bettina Malnic; Luciana Madeira Da Silva; Pedro Alexandre Favoretto Galante - October 2009, 02

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