CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Química Industrial from Universidade de Ribeirão Preto (1983), master's at Química Inorgânica from Universidade Estadual Paulista Júlio de Mesquita Filho (1987) and doctorate at Química Inorgânica from Universidade Estadual Paulista Júlio de Mesquita Filho (1992). Has experience in Chemistry, acting on the following subjects: óxido nítrico, rutênio, nitric oxide, nitrosil and complexos de rutênio. (Source: Lattes Curriculum)
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Light irradiation has long been used in several countries as an approved therapy against cancer, in a technique called Photodynamic Therapy (PDT). Essentially, the process uses light, oxygen and a photosensitizer (PS) to produce reactive oxygen species (ROS). However, PDT has proven to be more effective for early stages of cancer, as many more advanced tumors are hypoxic. In this project,…
It is known from previous studies that nitric oxide (NO) is a biological messenger of physiological and anticancer processes, and its functions depend on its concentration and place of action. These characteristics have motivated the search for a clinical application of compounds that can, in a controlled way, release NO. Among this possibility, the group led by prof. Roberto S. da Silva …
The discovery that nitric oxide (NO) can be used as a molecule with high cytotoxic potential, has driven researchers in order to prepare compounds that can act as release agents of NO by external stimulus. Several aspects of this feature should be considered in relation to: - rate release of NO; target where NO is released; formation of reactive nitrogen species; metabolism, among other f…
The objective of this project is the study of energy transfer between donor electron species and complex trans- [RuNO (pc-R) (N02)] (PC-R is modified phthalocyanine) as producing agents of reactive oxygen species (ROS) and nitrogen (ERONs) by light irradiation at 500 nm to 700 nm region. Measurements of NO, singlet oxygen and its derivatives shall be determined on the basis of different c…
(Only some records are available in English at this moment)
Radiation therapy (RT) is effective in combating cancer, but tumor resistance can limit its efficacy. Combining RT with chemotherapy aims to reduce doses, but concerns arise regarding toxicity to normal tissues. Photodynamic therapy (PDT) emerges as a promising alternative, utilizing photosensitizers (PSs) activated by visible light to destroy tumor cells. Although effective in various ca…
Photodynamic therapy (PDT) via X-rays is a promising technique for the treatment of oncological diseases, as this radiation penetrates deeper into tissues compared to PDT using light. Photosensitizers, mostly derived from porphyrins, play a crucial role in this therapy. Their advantages and limitations determine treatment efficiency. Thus, photosensitizers capable of controlled release of…
Hypoxia not only promotes tumor metastasis, but also strengthens tumor resistance to therapies that require the involvement of oxygen, such as photodynamic therapy (PDT). On this, taking advantage of the high reactivity of manganese dioxide (MnO2) and copper oxide (Cu2O) nanoparticles, for hydrogen peroxide (H2O2), in terms of O2 generation, we based the presented project. This research p…
(Only some records are available in English at this moment)
Nitric oxide (NO) is a biological messenger that is vitally important in many physiological processes, such as cardiovascular control, neural signaling and defense against microorganisms and tumors. In addition, NO is also anticancer, which would allow the use of NO donor compounds in clinical treatments. Based on the chemical and biological characteristics of the NO molecule, it is vital…
The ruthenium nitrosyl complexes had shown different biological activities, among them the antitumoral properties. Therefore, the aim of this work is the development of ruthenium-phtalocyanine conjugated with lanthanide dopped silica nanoparticles, once the nanoparticles absorb light in x-ray region and emit light in therapeutic window region, causing the nitric oxide release and allowin…
Nitric oxide (NO) radical species is involved in many biological processes. Notwithstanding the great importance of NO in biological systems, studies on their pharmacological and physiological properties are limited because of their high reactivity and short half-life time. Thus, the development of compounds that can release NO, can be an alternative to solve these problems and potentiall…
(Only some records are available in English at this moment)
Cancer is a substantial global health challenge, and conventional treatments frequently exhibit limitations and undesirable effects. This underscores the need to explore different and innovative therapeutic approaches. Photodynamic therapy (PDT) offers a minimally invasive alternative treatment that can be combined with other treatments. Although the effect of PDT on target cells is alrea…
The project submitted here untitled "Combination of metal based photosensitizers and low level light therapy as upgrade purpose of photodynamic therapy application" is part of the research line of Prof Roberto Santana da Silva (USP), and Michael R. Hamblin (Harvard School and Massachussets General Hospital). This involves the synergistic effect of low levels of visible or near-infrared (N…
The project submitted here untitled " Synergistic effect of low level light therapy, photodynamic therapy and chemotherapy using ruthenium phthalocianines and cisplatin as novel approach for cancer treatment" is part of the research line of Prof Roberto Santana da Silva (USP), and Michael R. Hamblin (Harvard School and Massachussets General Hospital). This involves the synergistic effect…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 18 / 14 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 22 / 12 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 52 / 37 | All research grants and scholarships |
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