Roberto Santana da Silva

• Abstract

  The discovery that nitric oxide (NO) can be used as a molecule with high cytotoxic potential, has driven researchers in order to prepare compounds that can act as release agents of NO by external stimulus. Several aspects of this feature should be considered in relation to: - rate release of NO; target where NO is released; formation of reactive nitrogen species; metabolism, among other...

  Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug, AP.R
• 13th European biological inorganic chemistry conference - EUROBIC 13, AR.EXT

• Abstract

  The objective of this project is the study of energy transfer between donor electron species and complex trans- [RuNO (pc-R) (N02)] (PC-R is modified phthalocyanine) as producing agents of reactive oxygen species (ROS) and nitrogen (ERONs) by light irradiation at 500 nm to 700 nm region. Measurements of NO, singlet oxygen and its derivatives shall be determined on the basis of different...

  Cytotoxicity and photo-cytotoxicity of nitrosyl ruthenium anticancer drug in aqueous solution or incorporated in a drug delivery system.an innovative purpose for metal based drug, AP.R

(Only some records are available in English at this moment)

• Abstract

  The ruthenium nitrosyl complexes had shown different biological activities, among them the antitumoral properties. Therefore, the aim of this work is the development of ruthenium-phtalocyanine conjugated with lanthanide dopped silica nanoparticles, once the nanoparticles absorb light in x-ray region and emit light in therapeutic window region, causing the nitric oxide release and allow...

  Evaluation of Ruthenium-phtalocyanine complex conjugated with lanthanide dopped silica theranostic effect over neoplastic cells, BP.MS

• Abstract

  Nitric oxide (NO) radical species is involved in many biological processes. Notwithstanding the great importance of NO in biological systems, studies on their pharmacological and physiological properties are limited because of their high reactivity and short half-life time. Thus, the development of compounds that can release NO, can be an alternative to solve these problems and potentia...

  Evaluation of cellular localization and cytotoxicity by fluorescence microscopy of ruthenium complexes as nitric oxide deliver agents. studies of chemical, kinetic and biological aspects, BP.MS

• Abstract

  Nitric oxide (NO) is a signaling biological molecule that is involved a vital role in many physiological processes, acting in cardiovascular control, neural signaling, tumor activity and defense mechanisms against microorganisms. In addition, NO is also known as anticancer agent which would enable the use of NO donor's compounds in clinical treatments, for example in Photodynamic Therap...

  Chemo-phototherapeutic process of phthalocyanine-ruthenium system and cisplatin: chemical and photobiological evaluation in aqueous solution and in drug delivery system, BP.DR

(Only some records are available in English at this moment)

• Abstract

  The project submitted here untitled " Synergistic effect of low level light therapy, photodynamic therapy and chemotherapy using ruthenium phthalocianines and cisplatin as novel approach for cancer treatment" is part of the research line of Prof Roberto Santana da Silva (USP), and Michael R. Hamblin (Harvard School and Massachussets General Hospital). This involves the synergistic effe...

  Synergistic effect of low level light therapy, photodynamic therapy and chemotherapy using ruthenium phthalocianines and cisplatin as novel approach for cancer treatment, BE.EP.DR

• Abstract

  The project submitted here untitled "Combination of metal based photosensitizers and low level light therapy as upgrade purpose of photodynamic therapy application" is part of the research line of Prof Roberto Santana da Silva (USP), and Michael R. Hamblin (Harvard School and Massachussets General Hospital). This involves the synergistic effect of low levels of visible or near-infrared ...

  Combination of ruthenium based photosensitizers and low level light therapy as upgrade purpose for photodynamic therapy application, BE.PQ

• Abstract

  Nitric oxide (NO) is a biological messenger that has vital importance in many physiological processes, such as cardiovascular control, the neural signaling and defense against microorganisms and tumors. Furthermore, NO is also anticancer which would allow the use of NO donor compounds in clinical trials, for example, in Photodynamic Therapy (PDT). Based on chemical and biological charac...

  Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug, BE.EP.DR

(Only some records are available in English at this moment)