- Research Grants
bachelor's at Bacharelado Em Ciências Biológicas from Universidade de São Paulo (2005), bachelor's at Licenciatura Em Ciências Biológicas from Universidade de São Paulo (2007), master's at Genetics from Universidade de São Paulo (2010) and PhD at Genetics from Universidade de São Paulo (2015). Has experience in Genetics, acting on the following subjects: placenta, x chromosome inactivation, allele specific expression, imprinted genes and herança epigenética. (Source: Lattes Curriculum)
X-chromosome inactivation (XCI) is an epigenetic phenomenon observed in female mammals cells to ensure transcriptional dosage compensation of X-linked genes between males (XY) and females (XX). Most processes and steps involved in XCI in mice are well studied, however, in humans our knowledge is still very limited, especially during early embryo development. Advances in single-cell whol...
Epigenetic phenomena as genomic imprinting and X chromosome inactivation (XCI) have been widely studied in mice. While most of the processes and steps involved in XCI in mice are well studied, in humans our knowledge is still very limited, specially during early embryo development.Advances in single-cell whole transcriptome high throughput sequencing techniques (RNA-Seq) bring a new era...
In mammals, X chromosome inactivation (XCI) is the transcriptional silencing of all but one X present in female normal somatic cells. This process ensures dosage compensation for X-linked genes among females (XX) and males (XY).There are two XCI patterns: random, where in each cell the Xi (inactive X) is chosen by chance; or imprinted, where the X chromosome activity depends on parental...
In female mammals, one X chromosome is transcriptionally inactivated (XCI), leading to dosage compensation between sexes, which is fundamental for embryo viability. We recently analyzed X chromosome allele-specific expression globally during human embryonic development, and identified the XCI process to start during human preimplantation development at the blastocyst stage in a random p...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
MELLO, Joana Carvalho Moreira de. Estudos da inativação do cromossomo X em humanos: iniciação e imprinting. 2015. Tese (Doutorado) – Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (09/17481-6)
MELLO, Joana Carvalho Moreira de. Estudo do padrão de inativação do cromossomo X em tecido extra-embrionário humano. 2010. Dissertação (Mestrado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (06/05382-5)