Maria Julia Manso Alves
CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Portugal
PHD in Biochemistry at the Universidade de São Paulo (USP) (1974), full professor since 2002 at the Department of Biochemistry, USP. Her main field of work is the interaction- Trypanosoma cruzi- mammalian host, identifying ligants and receptors in the invasion process. Elements of the extracellular matrix (laminin) and Tc85 group ( family gp85/trans-sialidase from T. cruzi) are being studied and the protein sequences involved identifyed by phage display and synthetic peptides. The relevance of vesicles from T. cruzi in the infectivity and post-transductional modifications of proteins from the infective stage of the parasite during the adhesion step and the signaling pathways involved are other focus of research (Source: Lattes Curriculum)
- Signaling pathways involved in the interaction of Trypanosoma Cruzi with extracellular matrix isolated from distinct cell lines, AP.R
Abstract
S-nitrosylation and phosphorylation are reversible post-translational modifications that have been implicated in the regulation of protein function. We described recently that S-nitrosylation and phosphorylation of proteins occur in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisan...
- Trypanosoma Cruzi signaling due to changes in the external conditions: ECM and pH changes, AP.R
Abstract
Herein we propose to identify posttranslational modifications of proteins from T. cruzi in two distinct conditions, both relevants for the infection step: adhesion to extracellular matrix and exposure to mild pH decrease (pH 6). Levels of phosphorylation and S-nitrosylation of proteins will be determined in both conditions, with special attention to the flagellar proteins, since flagel...
- Interaction between Trypanosoma cruzi and host: binders, receptors and conditioners of intracellular development, AP.TEM
Abstract
The acute phase of Chagas Disease presents a generalized infection, with Trypanosoma cruzi present in almost all the organs and in the interior of different types of cell: smooth, skeletal and cardiac muscle fibers, fibroblasts, endothelial, glial, Schwann cells, neurons, macrophages and adipocytes. The peripheral nervous system is compromised, as, for example, in the alterations that o...
(Only some records are available in English at this moment)
- The role of second messengers in the signaling pathways of the Trypanosoma Cruzi interaction with the extracellular matrix, BP.PD
Abstract
Post-translational modifications by phosphorylation and s-nitrosylation were detected by proteomic analysis in several key enzymes of cell signaling processes in the parasite when it comes into contact with ECM. Some of these proteins are involved in cAMP, cGMP and calcium-mediated signaling processes, such as cAMP phosphodiesterase (PDE) and calmodulin. This project aims to validate th...
- Parasite signaling pathways involved in the interaction of Trypanosoma Cruzi with extracellular matrix isolated from distinct cell lines, BP.PD
Abstract
S-nitrosylation is a reversible post-translational modification that has been implicated in the regulation of protein function. We described recently that S-nitrosylation of proteins occurs in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisano) showed that proteins from the cytoskel...
- Trypanosoma Cruzi adhesion to extracellular matrix from different cells: analysis of post-translational modifications and proteolysis of extracellular matrix elements, BP.IC
Abstract
It is well established in the literature that elements of the extracellular matrix (ECM) are involved in the Trypanosoma cruzi adhesion to mammalian cells. Our laboratory has recently shown that incubation of trypomastigotes (infectious form) extracellular matrix (ECM) from epithelial cells leads to changes in the levels of phosphorylation, nitration and S-nitrosylation of parasite prot...
- Identification of flagellar proteins from Trypanosoma Cruzi modified due to the parasite adhesion to the host extracelullar matrix and cytoskeleton, BP.PD
Abstract
Chagas disease was firstly described in 1909 and since them, different aspects of this illness have being studied. The adhesion step of the infective forms (trypomastigotes) to components of the extracellular matrix (ECM) seems to be essential for the establishment of the parasite inside the host cells. Glycoproteins from the gp85/Trans-sialidase family are crucial in this step. Althoug...
(Only some records are available in English at this moment)
| 14 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 21 / 8 | Completed scholarships in Brazil |
| 36 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 226 |
| Cit./Article | 18.8 |
| Data from Web of Science | |
REIS TEIXEIRA, ANDRE AZEVEDO; SARDINHA DE VASCONCELOS, VERONICA DE CASSIA; COLLI, WALTER; MANSO ALVES, MARIA JULIA; GIORDANO, RICARDO JOSE. Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins. PLoS Neglected Tropical Diseases, v. 9, n. 9, SEP 2015. Web of Science Citations: 9.
MANSO ALVES, MARIA JULIA; KAWAHARA, REBECA; VINER, ROSA; COLLI, WALTER; MATTOS, ELICIANE CEVOLANI; THAYSEN-ANDERSEN, MORTEN; LARSEN, MARTIN ROSSEL; PALMISANO, GIUSEPPE. Comprehensive glycoprofiling of the epimastigote and trypomastigote stages of Trypanosoma cruzi. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 182-192, JAN 16 2017. Web of Science Citations: 17.
MAGDESIAN, MARGARET H.; TONELLI, RENATA R.; FESSEL, MELISSA R.; SILVEIRA, MARIANA S.; SCHUMACHER, ROBERT I.; LINDEN, RAFAEL; COLLI, WALTER; ALVES, MARIA JÚLIA M.. A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Tzypanosoma cruzi infection. Experimental Cell Research, v. 313, n. 1, p. 210-218, Jan. 2007.
SILBER, ARIEL M.; GALVEZ ROJAS, ROBERT L.; URIAS, URSULA; COLLI, WALTER; ALVES, MARIA JÚLIA MANSO. Biochemical characterization of the glutamate transport in Trypanosoma cruzi. International Journal for Parasitology, v. 36, n. 2, p. 157-163, Feb. 2006.
SILBER, ARIEL M.; TONELLI, RENATA R.; MARTINELLI, MARCELA; COLLI, WALTER; ALVES, MARIA JÚLIA M.. Active transport of L-proline in Trypanosoma cruzi. Journal of Eukaryotic Microbiology, v. 49, n. 6, p. 441-446, Nov. 2002.
TONELLI, R. R.; TORRECILHAS, A. C.; JACYSYN, J. F.; JULIANO, M. A.; COLLI, W.; ALVES, M. J. M.. In vivo infection by Trypanosoma cruzi: The conserved FLY domain of the gp85/trans-sialidase family potentiates host infection. Parasitology, v. 138, n. 4, p. 481-492, APR 2011. Web of Science Citations: 10.
L.C. MILETTI; M. ALMEIDA-DE-FARIA; W. COLLI; M.J.M. ALVES. Immunocytochemical and biochemical detection of alpha-L-fucosidase in Trypanosoma cruzi. Brazilian Journal of Medical and Biological Research, v. 36, n. 5, p. 595-603, Maio 2003.
H. ULRICH; M.J.M. ALVES; W. COLLI. RNA and DNA aptamers as potential tools to prevent cell adhesion in disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 3, p. 295-300, Mar. 2001.
OLIVEIRA‚ M.F.; BIJOVSKY‚ A.T.; CARVALHO‚ T.U.; SOUZA‚ W.; ALVES‚ M.M.; COLLI‚ W.. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitology Research, v. 87, n. 12, p. 1043-1049, 2001.
MATTOS, ELICIANE C.; SCHUMACHER, ROBERT I.; COLLI, WALTER; ALVES, MARIA JULIA M.. Adhesion of Trypanosoma cruzi Trypomastigotes to Fibronectin or Laminin Modifies Tubulin and Paraflagellar Rod Protein Phosphorylation. PLoS One, v. 7, n. 10, OCT 4 2012. Web of Science Citations: 10.
MANSO ALVES, MARIA JULIA; KAWAHARA, REBECA; VINER, ROSA; COLLI, WALTER; MATTOS, ELICIANE CEVOLANI; THAYSEN-ANDERSEN, MORTEN; LARSEN, MARTIN ROSSEL; PALMISANO, GIUSEPPE. Comprehensive glycoprofiling of the epimastigote and trypomastigote stages of Trypanosoma cruzi. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 182-192, JAN 16 2017. Web of Science Citations: 17.
MAGDESIAN, MARGARET H.; TONELLI, RENATA R.; FESSEL, MELISSA R.; SILVEIRA, MARIANA S.; SCHUMACHER, ROBERT I.; LINDEN, RAFAEL; COLLI, WALTER; ALVES, MARIA JÚLIA M.. A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Tzypanosoma cruzi infection. Experimental Cell Research, v. 313, n. 1, p. 210-218, Jan. 2007.
SILBER, ARIEL M.; GALVEZ ROJAS, ROBERT L.; URIAS, URSULA; COLLI, WALTER; ALVES, MARIA JÚLIA MANSO. Biochemical characterization of the glutamate transport in Trypanosoma cruzi. International Journal for Parasitology, v. 36, n. 2, p. 157-163, Feb. 2006.
SILBER, ARIEL M.; TONELLI, RENATA R.; MARTINELLI, MARCELA; COLLI, WALTER; ALVES, MARIA JÚLIA M.. Active transport of L-proline in Trypanosoma cruzi. Journal of Eukaryotic Microbiology, v. 49, n. 6, p. 441-446, Nov. 2002.
TONELLI, R. R.; TORRECILHAS, A. C.; JACYSYN, J. F.; JULIANO, M. A.; COLLI, W.; ALVES, M. J. M.. In vivo infection by Trypanosoma cruzi: The conserved FLY domain of the gp85/trans-sialidase family potentiates host infection. Parasitology, v. 138, n. 4, p. 481-492, APR 2011. Web of Science Citations: 10.
L.C. MILETTI; M. ALMEIDA-DE-FARIA; W. COLLI; M.J.M. ALVES. Immunocytochemical and biochemical detection of alpha-L-fucosidase in Trypanosoma cruzi. Brazilian Journal of Medical and Biological Research, v. 36, n. 5, p. 595-603, Maio 2003.
H. ULRICH; M.J.M. ALVES; W. COLLI. RNA and DNA aptamers as potential tools to prevent cell adhesion in disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 3, p. 295-300, Mar. 2001.
OLIVEIRA‚ M.F.; BIJOVSKY‚ A.T.; CARVALHO‚ T.U.; SOUZA‚ W.; ALVES‚ M.M.; COLLI‚ W.. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitology Research, v. 87, n. 12, p. 1043-1049, 2001.
MATTOS, ELICIANE C.; SCHUMACHER, ROBERT I.; COLLI, WALTER; ALVES, MARIA JULIA M.. Adhesion of Trypanosoma cruzi Trypomastigotes to Fibronectin or Laminin Modifies Tubulin and Paraflagellar Rod Protein Phosphorylation. PLoS One, v. 7, n. 10, OCT 4 2012. Web of Science Citations: 10.
TROCOLI TORRECILHAS, ANA CLAUDIA; TONELLI, RENATA ROSITO; PAVANELLI, WANDER ROGERIO; DA SILVA, JOAO SANTANA; SCHUMACHER, ROBERT IVAN; DE SOUZA, WANDERLEY; CUNHA E SILVA, NARCISA; ABRAHAMSOHN, ISES DE ALMEIDA; COLLI, WALTER; MANSO ALVES, MARIA JULIA. Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response. Microbes and Infection, v. 11, n. 1, p. 29-39, JAN 2009. Web of Science Citations: 86.
PEREIRA, MILTON; SOARES, CHRISLAINE; BAPTISTA CANUTO, GISELE ANDRE; MAGGI TAVARES, MARINA FRANCO; COLLI, WALTER; ALVES, MARIA JULIA M.. Down Regulation of NO Signaling in Trypanosoma cruzi upon Parasite-Extracellular Matrix Interaction: Changes in Protein Modification by Nitrosylation and Nitration. PLoS Neglected Tropical Diseases, v. 9, n. 4, APR 2015. Web of Science Citations: 8.