CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Portugal
PHD in Biochemistry at the Universidade de São Paulo (USP) (1974), full professor since 2002 at the Department of Biochemistry, USP. Her work is focused in the the identification of ligands/receptors, pos-translational modifications and signaling during the interaction of Trypanosoma cruzi with host mammalian cell and extracellular matrix. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Un parásito listo para el ataque |
| Parasite poised for the attack |
| News published in Agência FAPESP Newsletter about the researcher |
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S-nitrosylation and phosphorylation are reversible post-translational modifications that have been implicated in the regulation of protein function. We described recently that S-nitrosylation and phosphorylation of proteins occur in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisano)…
Herein we propose to identify posttranslational modifications of proteins from T. cruzi in two distinct conditions, both relevants for the infection step: adhesion to extracellular matrix and exposure to mild pH decrease (pH 6). Levels of phosphorylation and S-nitrosylation of proteins will be determined in both conditions, with special attention to the flagellar proteins, since flagellu…
The acute phase of Chagas Disease presents a generalized infection, with Trypanosoma cruzi present in almost all the organs and in the interior of different types of cell: smooth, skeletal and cardiac muscle fibers, fibroblasts, endothelial, glial, Schwann cells, neurons, macrophages and adipocytes. The peripheral nervous system is compromised, as, for example, in the alterations that occ…
(Only some records are available in English at this moment)
Post-translational modifications by phosphorylation and s-nitrosylation were detected by proteomic analysis in several key enzymes of cell signaling processes in the parasite when it comes into contact with ECM. Some of these proteins are involved in cAMP, cGMP and calcium-mediated signaling processes, such as cAMP phosphodiesterase (PDE) and calmodulin. This project aims to validate the …
S-nitrosylation is a reversible post-translational modification that has been implicated in the regulation of protein function. We described recently that S-nitrosylation of proteins occurs in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisano) showed that proteins from the cytoskelet…
It is well established in the literature that elements of the extracellular matrix (ECM) are involved in the Trypanosoma cruzi adhesion to mammalian cells. Our laboratory has recently shown that incubation of trypomastigotes (infectious form) extracellular matrix (ECM) from epithelial cells leads to changes in the levels of phosphorylation, nitration and S-nitrosylation of parasite protei…
(Only some records are available in English at this moment)
| 1 / 0 | Ongoing research grants |
| 15 / 5 | Completed research grants |
| 22 / 10 | Completed scholarships in Brazil |
| 38 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 217 |
| Cit./Article | 13.6 |
| Data from Web of Science | |
MANSO ALVES, MARIA JULIA; KAWAHARA, REBECA; VINER, ROSA; COLLI, WALTER; MATTOS, ELICIANE CEVOLANI; THAYSEN-ANDERSEN, MORTEN; LARSEN, MARTIN ROSSEL; PALMISANO, GIUSEPPE. Comprehensive glycoprofiling of the epimastigote and trypomastigote stages of Trypanosoma cruzi. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 182-192, JAN 16 2017. Web of Science Citations: 17. (13/16478-7, 14/25494-9, 14/06863-3)
REIS TEIXEIRA, ANDRE AZEVEDO; SARDINHA DE VASCONCELOS, VERONICA DE CASSIA; COLLI, WALTER; MANSO ALVES, MARIA JULIA; GIORDANO, RICARDO JOSE. Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins. PLoS Neglected Tropical Diseases, v. 9, n. 9, SEP 2015. Web of Science Citations: 9. (13/16478-7, 08/54806-8)
L.C. MILETTI; M. ALMEIDA-DE-FARIA; W. COLLI; M.J.M. ALVES. Immunocytochemical and biochemical detection of alpha-L-fucosidase in Trypanosoma cruzi. Brazilian Journal of Medical and Biological Research, v. 36, n. 5, p. 595-603, Maio 2003. (99/12459-9)
H. ULRICH; M.J.M. ALVES; W. COLLI. RNA and DNA aptamers as potential tools to prevent cell adhesion in disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 3, p. 295-300, Mar. 2001. (99/12459-9)
MATTOS, ELICIANE C.; CANUTO, GISELE; MANCHOLA, NUBIA C.; MAGALHAES, RUBENS D. M.; CROZIER, THOMAS W. M.; LAMONT, DOUGLAS J.; TAVARES, MARINA F. M.; COLLI, WALTER; FERGUSON, MICHAEL A. J.; ALVES, MARIA JULIA M.. Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix. PLoS Neglected Tropical Diseases, v. 13, n. 2, FEB 2019. Web of Science Citations: 1. (13/16002-2, 16/14506-1, 18/03727-2, 14/25494-9)
SOARES, RODRIGO P.; XANDER, PATRICIA; COSTA, ADRIANA OLIVEIRA; MARCILLA, ANTONIO; MENEZES-NETO, ARMANDO; DEL PORTILLO, HERNANDO; WITWER, KENNETH; WAUBEN, MARCA; NOLTE-'T HOEN, ESTHER; OLIVIER, MARTIN; et al. Highlights of the Sao Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication. JOURNAL OF EXTRACELLULAR VESICLES, v. 6, n. 1, NOV 26 2017. Web of Science Citations: 9. (16/12111-0, 16/17245-4, 16/01917-3)
MAGDESIAN, MARGARET H.; TONELLI, RENATA R.; FESSEL, MELISSA R.; SILVEIRA, MARIANA S.; SCHUMACHER, ROBERT I.; LINDEN, RAFAEL; COLLI, WALTER; ALVES, MARIA JÚLIA M.. A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Tzypanosoma cruzi infection. Experimental Cell Research, v. 313, n. 1, p. 210-218, Jan. 2007. (04/03303-5)
SILBER, ARIEL M.; GALVEZ ROJAS, ROBERT L.; URIAS, URSULA; COLLI, WALTER; ALVES, MARIA JÚLIA MANSO. Biochemical characterization of the glutamate transport in Trypanosoma cruzi. International Journal for Parasitology, v. 36, n. 2, p. 157-163, Feb. 2006. (04/03303-5)
SILBER, ARIEL M.; TONELLI, RENATA R.; MARTINELLI, MARCELA; COLLI, WALTER; ALVES, MARIA JÚLIA M.. Active transport of L-proline in Trypanosoma cruzi. Journal of Eukaryotic Microbiology, v. 49, n. 6, p. 441-446, Nov. 2002. (99/12459-9)
OLIVEIRA‚ M.F.; BIJOVSKY‚ A.T.; CARVALHO‚ T.U.; SOUZA‚ W.; ALVES‚ M.M.; COLLI‚ W.. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitology Research, v. 87, n. 12, p. 1043-1049, 2001. (99/12459-9)
OLIVEIRA‚ M.F.; BIJOVSKY‚ A.T.; CARVALHO‚ T.U.; SOUZA‚ W.; ALVES‚ M.M.; COLLI‚ W.. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitology Research, v. 87, n. 12, p. 1043-1049, 2001. (99/12459-9)
MATTOS, ELICIANE C.; CANUTO, GISELE; MANCHOLA, NUBIA C.; MAGALHAES, RUBENS D. M.; CROZIER, THOMAS W. M.; LAMONT, DOUGLAS J.; TAVARES, MARINA F. M.; COLLI, WALTER; FERGUSON, MICHAEL A. J.; ALVES, MARIA JULIA M.. Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix. PLoS Neglected Tropical Diseases, v. 13, n. 2, FEB 2019. Web of Science Citations: 1. (13/16002-2, 18/03727-2, 16/14506-1, 14/25494-9)
COUTINHO, JOAO V. P.; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; DE OLIVEIRA, GILBERTO SANTOS; MANCHOLA, NUBIA CAROLINA; SANTIAGO, VERONICA FEIJOLI; COLLI, WALTER; WRENGER, CARSTEN; MANSO ALVES, MARIA JULIA; PALMISANO, GIUSEPPE. The thermal proteome stability profile of Trypanosoma cruzi in epimastigote and trypomastigote life stages. JOURNAL OF PROTEOMICS, v. 248, SEP 30 2021. Web of Science Citations: 0. (18/18257-1, 17/03966-4, 17/04032-5, 17/19854-0, 15/26722-8, 18/13283-4, 18/15549-1, 14/06863-3)
MULE, S. N.; MANCHOLA, N. C.; DE OLIVEIRA, G. S.; PEREIRA, M.; MAGALHAES, R. D. M.; TEIXEIRA, A. A.; COLLI, W.; ALVES, M. J. M.; PALMISANO, G.. Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix. JOURNAL OF PROTEOMICS, v. 231, JAN 16 2021. Web of Science Citations: 0. (14/25494-9, 14/10046-0, 18/03727-2, 17/04032-5, 18/18257-1, 18/13283-4, 18/15549-1, 12/03887-3)
KHUSAL, K. G.; TONELLI, R. R.; MATTOS, E. C.; SOARES, C. O.; DI GENOVA, B. M.; JULIANO, M. A.; URIAS, U.; COLLI, W.; ALVES, M. J. M.. Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells. Parasitology Research, v. 114, n. 1, p. 155-165, JAN 2015. Web of Science Citations: 5.
PEREIRA, MILTON; SOARES, CHRISLAINE; BAPTISTA CANUTO, GISELE ANDRE; MAGGI TAVARES, MARINA FRANCO; COLLI, WALTER; ALVES, MARIA JULIA M.. Down Regulation of NO Signaling in Trypanosoma cruzi upon Parasite-Extracellular Matrix Interaction: Changes in Protein Modification by Nitrosylation and Nitration. PLoS Neglected Tropical Diseases, v. 9, n. 4, APR 2015. Web of Science Citations: 5. (12/03887-3, 12/05621-0)
TONELLI, R. R.; COLLI, W.; ALVES, M. J. M.. Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro. FRONTIERS IN IMMUNOLOGY, v. 3, 2013. Web of Science Citations: 12. (10/15042-2)
CANEPA‚ G.E.; BOUVIER‚ L.A.; URIAS‚ U.; MIRANDA‚ M.R.; COLLI‚ W.; ALVES‚ M.J.M.; PEREIRA‚ C.A.. Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi. FEMS Microbiology Letters, v. 247, n. 1, p. 65-71, 2005. (04/03303-5)
TONELLI, RENATA R.; GIORDANO, RICARDO J.; BARBU, ELENA MAGDA; TORRECILHAS, ANA CLAUDIA; KOBAYASHI, GERSON S.; LANGLEY, ROBERT R.; ARAP, WADIH; PASQUALINI, RENATA; COLLI, WALTER; ALVES, MARIA JULIA M.. Role of the gp85/Trans-Sialidases in Trypanosoma cruzi Tissue Tropism: Preferential Binding of a Conserved Peptide Motif to the Vasculature In Vivo. PLoS Neglected Tropical Diseases, v. 4, n. 11, p. e864, 2010. Web of Science Citations: 28. (04/03303-5)
MARROQUIN-QUELOPANA, MIRYAM; OYAMA JÚNIOR, SERGIO; PERTINHEZ, THELMA AGUIAR; SPISNI, ALBERTO; JULIANO, MARIA APARECIDA; JULIANO, LUIZ; COLLI, WALTER; ALVES, MARIA JÚLIA M.. Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Biochemical and Biophysical Research Communications, v. 325, n. 2, p. 612-618, Dec. 2004. (99/12459-9)
ULRICH, HENNING; MAGDESIAN, MARGARET H.; ALVES, MARIA JÚLIA M.; COLLI, WALTER. In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion. Journal of Biological Chemistry, v. 277, n. 23, p. 20756-20762, June 2002. (99/12459-9)
SILBER, ARIEL M.; TONELLI, RNATA R.; LOPES, CAMILA G.; CUNHA-E-SILVA, NARCISA; TORRECILHAS, ANA CLAUDIA T.; SCHUMACHER, ROBERT I.; COLLI, WALTER; ALVES, MARIA JULIA M.. Glucose uptake in the mammalian stages of Trypanosoma cruzi. Molecular and Biochemical Parasitology, v. 168, n. 1, p. 102-108, NOV 2009. Web of Science Citations: 34. (04/03303-5)
MISERANI MAGALHAES, RUBENS DANIEL; MATTOS, ELICIANE CEVOLANI; ROZANSKI, ANDREI; FAVORETTO GALANTE, PEDRO ALEXANDRE; PALMISANO, GIUSEPPE; CRUZ, ANGELA KAYSEL; COLLI, WALTER; CAMARGO, ANAMARIA ARANHA; MANSO ALVES, MARIA JULIA. Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix. PLoS Neglected Tropical Diseases, v. 14, n. 5, MAY 2020. Web of Science Citations: 1. (18/18257-1, 14/06863-3, 13/16002-2, 18/15549-1, 14/25494-9, 14/10046-0)
BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5, MAY 2017. Web of Science Citations: 2. (15/50075-2, 12/04601-6, 12/07361-6, 14/25494-9, 12/18756-1)
MULE, SIMON NGAO; COSTA-MARTINS, ANDRE GUILHERME; ROSA-FERNANDES, LIVIA; DE OLIVEIRA, GILBERTO SANTOS; RODRIGUES, CARLA MONADELI F.; QUINA, DANIEL; ROSEIN, GRAZIELLA E.; GERALDES TEIXEIRA, MARTA MARIA; PALMISANO, GIUSEPPE. PhyloQuant approach provides insights into Trypanosoma cruzi evolution using a systems-wide mass spectrometry-based quantitative protein profile. COMMUNICATIONS BIOLOGY, v. 4, n. 1, MAR 11 2021. Web of Science Citations: 0. (18/13283-4, 17/04032-5, 14/06863-3, 18/15549-1, 18/18257-1, 14/25494-9)