PHD in Biochemistry at the Universidade de São Paulo (USP) (1974), full professor since 2002 at the Department of Biochemistry, USP. Her work is focused in the the identification of ligands/receptors, pos-translational modifications and signaling during the interaction of Trypanosoma cruzi with host mammalian cell and extracellular matrix. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Un parásito listo para el ataque |
| Parasite poised for the attack |
| News published in Agência FAPESP Newsletter about the researcher |
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S-nitrosylation and phosphorylation are reversible post-translational modifications that have been implicated in the regulation of protein function. We described recently that S-nitrosylation and phosphorylation of proteins occur in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisano)…
Herein we propose to identify posttranslational modifications of proteins from T. cruzi in two distinct conditions, both relevants for the infection step: adhesion to extracellular matrix and exposure to mild pH decrease (pH 6). Levels of phosphorylation and S-nitrosylation of proteins will be determined in both conditions, with special attention to the flagellar proteins, since flagellu…
The acute phase of Chagas Disease presents a generalized infection, with Trypanosoma cruzi present in almost all the organs and in the interior of different types of cell: smooth, skeletal and cardiac muscle fibers, fibroblasts, endothelial, glial, Schwann cells, neurons, macrophages and adipocytes. The peripheral nervous system is compromised, as, for example, in the alterations that occ…
(Only some records are available in English at this moment)
Post-translational modifications by phosphorylation and s-nitrosylation were detected by proteomic analysis in several key enzymes of cell signaling processes in the parasite when it comes into contact with ECM. Some of these proteins are involved in cAMP, cGMP and calcium-mediated signaling processes, such as cAMP phosphodiesterase (PDE) and calmodulin. This project aims to validate the …
S-nitrosylation is a reversible post-translational modification that has been implicated in the regulation of protein function. We described recently that S-nitrosylation of proteins occurs in T. cruzi trypomastigotes during their interaction with ECM, an obligatory step in the invasion process. Unpublished data (in collaboration with G. Palmisano) showed that proteins from the cytoskelet…
It is well established in the literature that elements of the extracellular matrix (ECM) are involved in the Trypanosoma cruzi adhesion to mammalian cells. Our laboratory has recently shown that incubation of trypomastigotes (infectious form) extracellular matrix (ECM) from epithelial cells leads to changes in the levels of phosphorylation, nitration and S-nitrosylation of parasite protei…
(Only some records are available in English at this moment)
| 16 / 5 | Completed research grants |
| 22 / 10 | Completed scholarships in Brazil |
| 38 / 15 | All research grants and scholarships |
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CV Lattes
ORCID