CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Biomedicina from Universidade Estadual de Londrina (2004). Has experience in , focusing on Biological Sciences, acting on the following subjects: plasmodium chabaudi as, pla, iab, cd1d, hla, ccr5, polimorfismo, paraná, quimiocina sdf1-3´a, leishmaniose, hiv, rna, ntt, p9 and rna sintético dupla fita, hep-2, citotoxicidade. (Source: Lattes Curriculum)
The control of gene expression is a complex network that could be mediated by three regulators: 1) transcription factors (TFs), via binding to regulatory DNA regions such as promoters or enhancers in the target gene that regulated mRNA transcription; 2) long noncoding RNA (lncRNA), via interaction with DNA, RNA or protein, regulating the chromosomal structure, transcription of mRNAs and m…
Post-transcriptional regulation mediated by microRNAs in infectious processes caused by bacteria, viruses and parasites, as well as tumor cells, is intensively studied in recent years. The Leishmania infection is also able to modulate the expression of miRNAs and regulate genes involved in macrophage response to parasite. The Leishmania-modulation of miRNAs expression of macrophage could …
The hypothesis of this project is that the miRNA profile of macrophage can be altered during entry and replication of Leishmania amazonensis infection on macrophage, and can subvert the host immune response. In this way, the change in the miRNAs profile of macrophages, it is involved in the control of pos-transcriptional levels in the intracellular signaling the pathways of the innate imm…
Mammalian host infected with protozoan parasite Leishmania amazonensis causes a cutaneous leishmaniosis, a neglected disease that present a higher prevalence in Brazil. The establishment of immunological response uses post-transcriptional resources, such as microRNAs, which are largely studied in leishmaniasis. The ways to forward the control of gene expression regulation from polyamines …
The protozoan Leishmania can subvert the immune response against intracellular pathogens through the regulation of gene expression, such as transcriptional and post-transcriptional mechanisms for the establishment of the infection. The transcriptional mechanisms occur through the action of transcription factors, which can bind to the promoter region of the gene, inducing its transcription…
Leishmania is a protozoan parasite that is the causative agent of Leishmaniasis. This parasite alternate its life cycle between promastigotes inside the invertebrate host and amastigotes inhabiting immune phagocytic cells on the vertebrate host, among then, the macrophages. Parasites subvert the activation of macrophages microbicidal mechanisms, favoring the polyamines production by the A…
| 1 / 1 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 1 / 0 | Completed scholarships in Brazil |
| 9 / 6 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 75 |
| Cit./Article | 8.3 |
| Data from Web of Science | |
MUXEL, SANDRA M.; AOKI, JULIANA I.; FERNANDES, JULIANE C. R.; LARANJEIRA-SILVA, MARIA F.; ZAMPIERI, RICARDO A.; ACUNA, STEPHANIE M.; MULLER, KARL E.; VANDERLINDE, RUBIA H.; FLOETER-WINTER, LUCILE M.. Arginine and Polyamines Fate in Leishmania Infection. FRONTIERS IN MICROBIOLOGY, v. 8, JAN 15 2018. Web of Science Citations: 12. (15/25942-4, 16/22896-4, 14/50717-1, 16/19815-2)
MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. SCIENTIFIC REPORTS, v. 7, MAR 9 2017. Web of Science Citations: 26. (10/52688-8, 14/20809-1, 12/15263-4, 14/50717-1)
MUXEL, SANDRA MARCIA; ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. FRONTIERS IN IMMUNOLOGY, v. 9, NOV 29 2018. Web of Science Citations: 3. (14/50717-1, 16/19815-2, 14/20809-1, 16/03273-6, 17/23519-2)
ACUNA, STEPHANIE MAIA; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. MicroRNAs: Biological Regulators in Pathogen-Host Interactions. CELLS, v. 9, n. 1, JAN 2020. Web of Science Citations: 0. (17/23519-2, 18/23512-0, 18/24693-9)
AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. The impact of arginase activity on virulence factors of Leishmania amazonensis. Current Opinion in Microbiology, v. 52, p. 110-115, DEC 2019. Web of Science Citations: 0. (17/23933-3, 14/50717-1, 16/03273-6, 16/19815-2)
MARCIA MUXEL, SANDRA; MAMANI-HUANCA, MARICRUZ; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA; LOPEZ-GONZALVEZ, ANGELES; BARBAS, CORAL. Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 24, DEC 2019. Web of Science Citations: 0. (17/23519-2, 18/23512-0, 18/24693-9, 16/03273-6)
MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; CARVALHO-SOUSA, CLAUDIA EMANUELLE; FLOETER-WINTER, LUCILE MARIA; MARKUS, REGINA P.. The RelA/cRel nuclear factor-B (NF-B) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. Journal of Pineal Research, v. 60, n. 4, p. 394-404, MAY 2016. Web of Science Citations: 22. (10/52688-8, 13/13691-1, 12/15263-4, 14/50717-1)
RIBEIRO FERNANDES, JULIANE CRISTINA; AOKI, JULIANA IDE; ACUNA, STEPHANIE MAIA; ZAMPIERI, RICARDO ANDRADE; MARKUS, REGINA P.; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 9, MAR 20 2019. Web of Science Citations: 2. (14/50717-1, 16/19815-2, 16/03273-6, 12/15263-4, 17/23519-2)
ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; RIBEIRO FERNANDES, JULIANE CRISTINA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis. PLoS One, v. 12, n. 11, NOV 14 2017. Web of Science Citations: 10. (15/25942-4, 16/19815-2, 14/50717-1)
(References retrieved automatically from State of São Paulo Research Institutions)
MUXEL, Sandra Marcia. Papel das células T convencionais e não-convencionais do baço durante a infecção pelo Plasmodium chabaudi AS.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/54889-2)