CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Postgraduate degree in Biomedicine from the University State of Londrina (2004), PhD in Immunology from the University of São Paulo (2011) and Post-doctorate in Immunology from the University of São Paulo (2012-2016). Post-doctorate at the Center of Excellence in Metabolomics and Bioanalysis (CEMBIO- USP - Madrid, Spain). She currently works as a Laboratory Specialist and researcher in the Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo. I have experience in the area of #8203;#8203;Immunology and molecular biology, with an emphasis on cellular immunology and infectious diseases (leishmaniasis and malaria). I work as coordinator of FAPESP and CNPq research and extension projects (Biotreco - BiocientistaMirim - USP). My line of research aims to study how non-coding RNAs, microRNAs and long non-coding RNAs act in the regulation of gene expression during the pathogen-host interaction. We explored the role of these molecules in the transcriptional and post-transcriptional regulation of genes involved in macrophage activation during. infection with Leishmania. (Source: Lattes Curriculum)
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The modulation of macrophage activation is mediated by long noncoding RNA (lncRNA) and microRNAs (miRNAs), acting in the transcriptional and/or post-transcriptional regulation of genes that can promote the death of Leishmania. lncRNAs regulate chromosomal structure, mRNA transcription, splicing and protein translation. MiRNAs regulate the translation and degradation of the target gene tra…
Understanding as parasite and host factors contribute to the pathogenesis of leishmaniasis is highly relevant to understanding the modulation of macrophage activation mediated by long noncoding RNA (lncRNA) and microRNAs (miRNAs). They can influence the transcriptional and post-transcriptional regulation of genes that can promote the survival or death of the parasite. The lncRNAs regulate…
The control of gene expression is a complex network that could be mediated by three regulators: 1) transcription factors (TFs), via binding to regulatory DNA regions such as promoters or enhancers in the target gene that regulated mRNA transcription; 2) long noncoding RNA (lncRNA), via interaction with DNA, RNA or protein, regulating the chromosomal structure, transcription of mRNAs and m…
Post-transcriptional regulation mediated by microRNAs in infectious processes caused by bacteria, viruses and parasites, as well as tumor cells, is intensively studied in recent years. The Leishmania infection is also able to modulate the expression of miRNAs and regulate genes involved in macrophage response to parasite. The Leishmania-modulation of miRNAs expression of macrophage could …
(Only some records are available in English at this moment)
In this project, we aim to evaluate the function of the long non-coding (lncRNAs) NKILA and PACER in the regulation of NF-kB and activation of microbicidal mechanisms in macrophages infected with Leishmania infantum. We formulated the hypothesis that infection with L. infantum alters the expression of the lncRNAs NKILA and PACER and consequently the activation of NFkB and genes for the ac…
In this project, we aim to investigate their influence on the regulation of the expression of miR-294 and miR-302 during the response of macrophages infected with L. infantum. We formulated the hypothesis that infection with L. infantum increases the expression of miR-294 and miR-302 and these affect the mRNA levels of target genes related to the production of cytokines and NO in macropha…
In this project, we aim to understand the function of miR-372 and miR-373 in the regulation of HIF1A and its network of target genes and the impact on the response of macrophages infected with Leishmania infantum. We formulate the hypothesis that infection with L. infantum leads an increase the of miR-372/373 expression and these molecules alter the levels of HIF-1± mRNA/protein and, cons…
(Only some records are available in English at this moment)
In this project, we aim to evaluate the interaction of the Hypoxia inducible-factor 1a transcription factor (HIF-1a) and the long noncoding RNA HIF1A-AS3 and its role in glycolytic metabolism in macrophages infected with Leishmania infantum. We hypothesized that infection with L. infantum changes the oxygen supply and induces the gene expression of HIF-1± and the lncRNA encoded in the ant…
Mammalian host infected with protozoan parasite Leishmania amazonensis causes a cutaneous leishmaniosis, a neglected disease that present a higher prevalence in Brazil. The establishment of immunological response uses post-transcriptional resources, such as microRNAs, which are largely studied in leishmaniasis. The ways to forward the control of gene expression regulation from polyamines …
The protozoan Leishmania can subvert the immune response against intracellular pathogens through the regulation of gene expression, such as transcriptional and post-transcriptional mechanisms for the establishment of the infection. The transcriptional mechanisms occur through the action of transcription factors, which can bind to the promoter region of the gene, inducing its transcription…
(Only some records are available in English at this moment)
The relationship of long noncoding RNAs (lncRNAs) in the immunometabolic connections during Leishmania infection remains poorly tested. Here, we propose an integrative approach to study the function of lncRNA HIF1A-AS3 encoded in HIF1A antisense strand in the Leishmania-induced shifts in metabolic networks in murine macrophages, deciphering the molecular mechanisms of this phenomenon and …
In this project, we aim to evaluate the function of miR-372/373 in the regulation of glucose metabolism in macrophages infected with Leishmania infantum. We hypothesize that the infection with L. infantum increases the expression of human miR-372/miR-373, and these molecules alter the mRNA/protein levels of HIF-1± and consequently a network of target genes involved in glycolysis in macrop…
The dynamic and complex metabolic coupling established between Leishmania and its host results from a long co-evolutionary process. Due to the constant and sudden alterations imposed by the host microenvironment, such metabolic coupling continues to be dynamically regulated. The constant pursuit and competition for nutrients within the host-Leishmania duet will alter the host metabolic pa…
| 1 / 1 | Ongoing grants |
| 7 / 4 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 20 / 16 | All research grants and scholarships |
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