Denise de Oliveira Silva

• Abstract

  The research in our laboratory is focused on the study of metallodrugs to open new perspectives in the fields of bioinorganic and pharmacology with the development of new drug candidates and new formulations that may show potential impact on human health treatment. The work is mainly directed to synthesis, characterization, reactivity and biological activity of ruthenium compounds bearing…

  STUDY OF RUTHENIUM METALLODRUGS AND NANOPARTICLE SYSTEMS OF THESE METALLODRUGS TARGENTING CANCER THERAPY, AP.R

• Abstract

  Ruthenium compounds containing bioactive ligands such as non-steroidal anti-inflammatory drugs (NSAIDs) are the main focus of research in our laboratory with the purpose of finding novel metallodrugs. Compounds containing multiple metal-metal bonded Ru2(II,III) cores coordinated to NSAIDs have been found in pre-clinical studies to show anticancer properties against models of the highly ma…

  Anticancer metallodrugs of ruthenium containing bioactive ligands: synthesis, interaction with biomolecules and preparation of biocompatible nanoparticle drug delivery systems, AP.R

• Abstract

  This project has the purpose of studying metallotherapeutic drugs as strategic field of bioinorganic with multidisciplinary character involving pharmacological and biological aspects. Previous works of our group gave evidences for anti-inflammatory activity of copper and ruthenium metallodrugs with NSAIDs (non-steroidal anti-inflammatory drugs) and for antiproliferative action of diruthen…

  Anti-inflammatory and antitumor metallotherapeutic drugs: reactivity, properties and interactions with biocompatible hosts, AP.R

(Only some records are available in English at this moment)

• Abstract

  In the context of the Bioinorganic Chemistry, special attention has been dedicated to the investigation of metal complexes with potential application in pharmacology/medicine. Diruthenium compounds containing non-steroidal anti-inflammatory drugs (NSAIDs) have been subject of study in our laboratory for many years with the aim of developing novel metallodrugs. The anticancer potential of …

  Study of the chemical behaviour of metallodrugs of diruthenium(II,III) containing anti-inflammatories, BP.IC

• Abstract

  Ruthenium compounds have received great attention in the field of metallodrugs because of their potential as anticancer agents. Complexes containing Ru2(II,III) dimetal cores coordinated to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) developed in our research group have shown promising results in studies in vitro and in vivo in glioma models, such as the glioblastoma multiforme, a high…

  Study of lipid-based nanoparticles as carriers for anticancer ruthenium metallodrugs, BP.DD

• Abstract

  Complexes of Cu(II) with non-steroidal anti-inflammatory drugs (NSAIDs) have relevance in the field of the development of new metal-based drugs. These complexes show interest due to both the anti-inflammatory activity and the reduced side-effects compared to the correspondent parent organic drugs of clinical use. The main objective of the present project is the investigation of the intera…

  Studies on interactions of copper anti-inflammatory metallodrugs and chitosan and alginate, BP.IC

• Abstract

  Ruthenium compounds have received great attention in the field of metallodrugs because of their potential as anticancer agents. Complexes containing Ru2(II,III) dimetal cores coordinated to non-steroidal anti-inflammatory drugs (NSAIDs) developed in our research group have shown promising results in studies in vitro and in vivo in glioma models, such as the glioblastoma multiforme, a high…

  Study of lipid based nanoparticles as carriers for anticancer ruthenium metallodrugs, BE.EP.DD