- Research Grants
graduate at Ciências Biológicas from Universidade Federal de Santa Catarina (2002), master's at Physiology from Universidade Federal de Santa Catarina (2005) and ph.d. at Cancerology from Fundação Antônio Prudente (2009). Has experience in Biochemistry, acting on the following subjects: vesículas sinápticas, nucleotídeos da guanina, glutamato, derivados da guanina and transporte. (Source: Lattes Curriculum)
Soft tissue sarcomas (STS) are rare neoplasms with different morphological patterns of mesenchymal cells that can evolve with high rates of morbidity and mortality. High-grade tumors larger than 10 cm and deep have a worse prognosis due their high metastatic capacity (mainly to the lungs), with median survival not exceeding 15%. The low efficacy in the treatment of these tumors is in pa...
The cochaperone STI1 forms a protein complex with Hsp70 and 90 and that supports proper protein folding. STI1 is secreted associated to endosomal vesicles, once in extracelular space, it interacts with prion protein (PrPC) on plasma membrane and triggers several trophic effects, such as proliferation, protection against cell death, differentiation and migration. Such effects were observ...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|