- Research Grants
Bachelor's at Licenciatura em Química from Universidade Estadual de Campinas (2007), bachelor's at Bacharelado em Química from Universidade Estadual de Campinas (2007), master's at Chemistry from Universidade Estadual de Campinas (2009) and doctorate at Chemistry from Universidade Estadual de Campinas (2013). Has experience in Chemistry, acting on the following subjects: molecular dynamics, nuclear receptors, dinâmica molecular, receptores nucleares and simulação computacional. (Source: Lattes Curriculum)
Obesity is a medical condition resulting from the loss on the balance between food intake and energy expenditure. It predisposes the organism to various other illnesses, such as cardiovascular disease and diabetes mellitus type 2, and it is currently considered one of the ten major public health problems in the world. New studies have shown that diets high in animal fat can cause inflam...
Nuclear receptors are a superfamily of proteins responsible for the transcription of several genes involved in fundamental biological processes, like cellular differentiation, control of metabolic rates, hormone regulation, reproduction, morphogenesis, etc.. Much of the cellular activity of these proteins is mediated by their association with hormones. The biophysical and biochemical st...
We propose a molecular dynamics simulations study of the thyroid hormone nuclear receptor (TR) and several (25) mutants of the TR-beta isoform in order to investigate the structural and dyamical changes of the mutants with respect to the TR-beta wild type. The mutations we intend to investigate are largely involved in the thyroid hormone resistance syndrome, in an attempt to contribute ...
The toll-like receptor 4 (TLR4) is a transmembrane protein of the innate immune system responsible for recognizing lipopolysaccharides (LPS), essential components of the Gram-negative bacteria outer membrane. The association of LPS to TLR4 promotes its homodimerization, which triggers an inflammatory response. Given its role in the innate immune system, TLR4 is an important target in dr...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Paulo Cesar Telles de. Modelagem molecular de receptores nucleares : estrutura, dinâmica e interação com ligantes. 2013. Tese (Doutorado) – Instituto de Química. Universidade Estadual de Campinas.
SOUZA, Paulo Cesar Telles de. Simulações de dinamica molecular de mutantes do receptor do hormonio tireoideano. 2009. Dissertação (Mestrado) - Instituto de Química. Universidade Estadual de Campinas (UNICAMP).