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Paulo Cesar Telles de Souza

CV Lattes ResearcherID ORCID

Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ)  (Institutional affiliation from the last research proposal)
Birthplace: Brazil

After completing my studies as a chemistry technician and working for two years at a glass factory (a French company - Saint Gobain), I began my Bachelors and Licentiate degrees in Chemistry in 2003 at the University of Campinas, one of the top technological universities in Brazil and Latin America. I quickly developed an interest in science, which encouraged me to start working with Prof. Munir S. Skaf. With a background in Physical Chemistry, my training during my Master's (2007-2009) and PhD (2009-2013) with Prof. Skaf was mainly in Molecular Biophysics. I applied computational and theoretical methods to biological problems with medical relevance. In particular, I gained experience in code development, force-field parametrization, and computational studies involving nuclear receptors and kinases, including the effects of disease-related mutations, protein-protein interactions, protein conformational changes, and protein-ligand interactions. Most of these studies were conducted in exciting collaborations with experimental research groups, including biophysicists, structural biologists, medicinal chemists, and medical doctors.As a post-doc, I trained in one of the worlds leading laboratories in Computational Biophysics, the Molecular Dynamics Group led by Prof. Siewert J. Marrink at the University of Groningen (one of the top universities in Europe, located in the Netherlands). I specialized in molecular simulations of water-soluble proteins (such as SOD1) and also learned about modeling bilayers, transmembrane proteins (Toll-like receptors, ECF transporters, Signal Peptidase Complex-SPC), DNA-lipid complexes, materials, and (bio)technological applications. I am one of the main developers of the new generation of the Martini coarse-grained (CG) force-field, one of the most popular CG models in the world. In collaboration with nine other research groups, we finished a new version of Martini in 2021, called Martini 3. The new model allows more accurate predictions of molecular packing and interactions, with potential new applications in drug design, which is now part of my future research plans at École normale supérieure (ENS) de Lyon and CNRS (Lyon, France), in collaboration with companies and many academic partners worldwide.I am currently the group leader of a project hosted at the Centre Blaise Pascal de Simulation et de Modélisation Numérique and also part of the Dynamics and Control of Biological Assemblies and Macromolecular Machines (DAMM) team, an horizontal group of researchers at the Laboratoire de Biologie et Modélisation de la Cellule. (Source: Lattes Curriculum)

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