CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor, Department of Physiology and Biophysics, ICB / USP. He holds a Master's degree in Food Science and a PhD in Morphofunctional Sciences from the University of São Paulo and a postdoctoral degree from the University of Texas Southwestern Medical Center. Has experience in the following subjects: leptin, obesity, central control of glycemic homeostasis, energy balance and neuroendocrinology. It uses neuroanatomical, histological, molecular biology and genetic manipulation methods to investigate molecular mechanisms predisposing to obesity and diabetes mellitus via the study of neural circuits. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| A delicate balance |
| Un equilibrio delicado |
| Enemigo de las dietas |
| An enemy unknown |
| News published in Agência FAPESP Newsletter about the researcher |
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The growth hormone (GH) is secreted by the anterior pituitary gland and is related to the regulation of several important physiological functions, such as cell proliferation, tissue growth, protein synthesis, carbohydrate and lipid metabolism, among others. Classically, the main target tissues of GH are the liver, skeletal muscle, bones and adipose tissue which, taken as a whole, were bel…
The Minispec LF50 (compact magnetic resonance device), manufactured by Bruker, allows the analysis of the body composition of mice up to 60 grams (therefore it is not compatible with rats) using an MRI method, but without generating images. The data provided by the equipment refers to the amount of fat, lean mass and body water in the analyzed animal, in relation to its body weight. Analy…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
GH is the most abundant factor secreted by the pituitary gland and plays an important role controlling somatic and tissue growth, as well as cell proliferation and differentiation. Despite the presence of the GH Receptor (GHR) in the brain, little is known about the effects of this hormone on the nervous system. Thus, we propose in this project that GH has a previously unrecognized role i…
Weight regain frequently follows interventions that reduce body weight, leading to a failure in long-term obesity treatment. Inhibitory proteins of the leptin signaling pathway, such as the suppressor of cytokine signaling 3 (SOCS3), have been studied in conditions that predispose animals to obesity. However, whether SOCS3 modulates post-restriction hyperphagia and weight regain remains u…
The metabolic programming can be defined as permanent changes in animal physiology and metabolism that were caused by periods in which the organism has been subjected to some forms of stress. Metabolic programming has been studied in more details during embryo development, when, for example, nutritional changes in the mother are able to predispose embryos/fetuses to an increased risk of m…
(Only some records are available in English at this moment)
Reproductive activity is coordinated by the interaction between the hypothalamic-pituitary-gonadal (HPG) axis, hormone secretion and neuronal stimuli. The gonadotrophic hormones, among other pituitary hormones, act in the gonads through the bloodstream so that gametogenesis and secretion of gonadal hormones are maintained in a proper way to propitiate reproduction. It is known that altera…
Reproduction plays a fundamental role in the maintenance of species, making it important to understand aspects involving reproductive processes. In the hypothalamus, nuclei such as the hypothalamic arcuate (ARH), anteroventral periventricular, and anterior periventricular (AVPV/PeN) nuclei are prominent in controlling reproduction. These nuclei contain neurons expressing the leptin recept…
The hypothalamus is one of the main brain areas responsible for energy metabolism regulation. The arcuate nucleus of hypothalamus (ARH) plays a crucial role in this regulation due to the presence of AgRP and POMC neurons, which are vital for the regulation of food intake and energy expenditure. Loss of function or deletion of some cellular and signaling factors from these neurons can impa…
(Only some records are available in English at this moment)
Several neural populations that control metabolism show GH receptor (GHR) expression. Furthermore, according to recent publications by our group, GHR ablation in some neuron populations causes metabolic changes. Given these findings, one of the objectives of the Thematic Project is to investigate the potential of other neural populations in the metabolic effects induced by GH. Since we pr…
The GH pituitary secretion is regulated by negative feedback loops via hypothalamic neurons. In this regard, hypothalamic neurons that produce GHRH act by stimulating GH synthesis, whereas somatostatin (SST) acts as GH secretion inhibitor. However, only a small portion of the GHRH neurons express GH receptor (GHR) (Wasinski et al., J Neurosci 40: 4309-4322, 2020). In addition, our researc…
The Lateral Hypothalamic Area (LHA) contains several neural populations that control important vegetative and metabolic functions, including food intake, energy expenditure, autonomic control, and several cognitive aspects, such as wakefulness-sleep cycle and reward system. Therefore, the understanding of how hormonal factors affect the functioning and activity of these neurons is fundame…
(Only some records are available in English at this moment)
Obesity is strongly associated with a variety of adverse health outcomes and the increase in childhood obesity is particularly alarming. More than 42 million children under 5 years of age are estimated to be overweight (World Health Organization) and childhood obesity tracks strongly with adolescent and adulthood obesity. Of particular concern is a growing prevalence of obesity in women o…
Approximately 17% of U.S. children and adolescents are obese, and are thus at high risk of developing further complications in adulthood. Animal models recapitulate epidemiological observations in humans that rapid early growth rates (1-3 weeks in rodents and 1-2 years of age in children) are associated with later obesity risk, independent of birth weight. Using the mouse model system, th…
| 3 / 3 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 15 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 29 / 28 | All research grants and scholarships |
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