Abstract
Diabetes mellitus (DM) is a complex disease that affects all organs of the body and whose prevalence is expanding in almost all countries of the world. The number of individuals with DM in Brazil increased from 2.7 to 11.7 million individuals from 1980 to 2014 (The Lancet 2016 387, 1513-1530). Regardless of the intrinsic mechanisms involved in the genesis of target organ involvement by di…