- Research Grants
graduate at Ciências Biológicas Modalidade Médica from Universidade de Santo Amaro (1983), master's at Immunology from Universidade de São Paulo (1989) and ph.d. at Immunology from Universidade de São Paulo (1995). Has experience in Immunology, focusing on Immunochemistry, acting on the following subjects: monoclonal and recombinant antibodies, immunoteraphy and snake venoms. (Source: Lattes Curriculum)
Our goal in this project is to produce and characterize antibodies containing the single chain Fragment variable - scFv - anti-toxins from snake venoms, viewing to understand their mechanisms of action and a possible therapeutic alternative for snake bites of the genus Crotalus and Bothrops.Accidents caused by snake venoms were included in the list of Neglected Tropical Diseases of WHO....
(Only some records are available in English at this moment)
Our goal in this project is to study the affinity of mutant human antibody scFv anti-crotoxin, seeking to understand the mechanisms of action of crotoxin and a possible alternative treatment for poisoning by the bite of snakes of the genus Crotalus. Crotalus poisoning, although accounting for only 8% of cases, it has the highest mortality. The venom has several toxins, crotoxin (CTX) pr...
Administration of heterologous antibodies, generally produced in horses, has been the treatment of choice to persons who suffered accidents by snake venoms. However, this kind of therapy can induce adverse reactions. Small fragments of antibodies containing only the VH and VL domains, known as Fv (Fragment variable) or single chain Fv (scFv) were constructed by genetic engineer aiming t...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|