- Research Grants
Graduated in Biological Sciences, B.Sc and Licenciate (Institute of Biosciences, University of Sao Paulo, 2004-2007) and PhD in Cell and Tissue Biology (Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, 2009-2014), with a period at Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), USA. Post-doctoral fellow at Institute of Biomedical Sciences, University of Sao Paulo (2014-2017), with a period at Department of Physiology, Development and Neurosciences - Centre for Trophoblast Research, University of Cambridge, UK. Currently work as Scientific Coordinator at R&D Department at Clínica Huntington, Brazil. (Source: Lattes Curriculum)
The Endoplasmic Reticulum (ER) is responsible for synthesis and addressing of secreted and membrane proteins. Adverse environmental conditions may lead to disruption of ER homeostasis causing accumulation of unfolded/misfolded proteins in ER, a phenomenon known as ER stress. ER stress activates the Unfolded Protein Response (UPR) that acts in several signaling cascades to improve chaper...
Using a Signal Sequence Trap method (SST) Hamada et al. (1996) have isolated the cDNA encoding of a novel secretory protein from a stroma cell line ST2 that can support differentiation of hematopoietic cells (Ogawa et al., 1988). They determined the complete nt sequences of this mouse and human protein nominating it stroma derived factor 2, SDF-2. The Amino Acid (aa) sequence deduced fr...
The stromal cell derived factor 2 (SDF2) was first described by Hamada et al. (1996); it is well conserved in mammals but its function is not fully understood. In human and mouse, SDF2 has a paralogous gene, SDF2L1 (78% similar in protein sequence). Human SDF2L1 is an endoplasmic reticulum-stress inducible-gene, whose function is related to quality control of new synthesized proteins. I...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
LORENZON, Aline Rodrigues. Expressão e possível função do Fator 2 derivado de células estromais (SDF2) na gestação.. 2014. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/03510-4)