CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmácia from Universidade Federal Fluminense (1981), master's at Farmacos e Medicamento from Universidade de São Paulo (1987) and ph.d. at Biochemistry from Universidade de São Paulo (1995). Has experience in Pharmacy, focusing on Pharmacotechnie, acting on the following subjects: praziquantel, lipossomas, nanotecnologia, fosfatidilcolina and liposomes. (Source: Lattes Curriculum)
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Nanostructured systems with mucoadhesive properties have great potential to be employed in drug release. These systems may increase the residence time of the systems at the site of action or absorption, enhancing drug contact with the mucosal epithelial barrier. The increased of the residence time and of the accumulation of drugs at pathological sites associated with drug controlled rele…
Inflammatory bowel diseases (IBD) cause chronic inflammation in the gastrointestinal system. The most prevalent IBDs are Crohn's disease (CD) and ulcerative colitis (UC), differing in the location of inflammation. As a first-choice treatment for IBD, mesalazine (MLZ) has been widely explored. MLZ inhibits the COX-1 and COX-2 enzymes, helping to reduce inflammation, but in the long term, i…
Alzheimer's disease (AD), the neurodegenerative disorder with the highest prevalence among cases of dementia in the world, is characterized by functional and cognitive decline, with emphasis on memory loss. The current treatment involves acetylcholinesterase inhibitors that causes significant adverse effects such as nausea, vomiting and liver toxicity. Thus, alternatives to the treatment …
Colorectal cancer (CC) ranks the third among the most common worldwide, which reinforces the urgent need for more effective or alternative treatments. A special emphasis regarding treatment modalities should consider drugs that can act against the angiogenesis process, which is directly related to tumor development. Based on nanotechnology tools, the development of polymeric nanoparticles…
Colorectal Cancer is a public health problem, among types of Cancer occupy the third position in terms of incidence and the second in mortality. For years, intravenous chemotherapy has been the therapeutic resource used in the treatment of Cancer, however, limited therapeutic efficacy and adverse effects compromise the use by this route. Bevacizumab (BVZ) was the first FDA approved (Food …
(Only some records are available in English at this moment)
Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Amyotrophic lateral sclerosis share the common feature of pathological protein aggregation that become toxic to brain tissue leading to cell death. While in Alzheimer's beta-amyloid (²A) and Tau proteins aggregate in insoluble amyloid plaques and neurofibrillary tangles, in Parkinson's disease (PD) alfa-synucle…
Colorectal cancer (CRC) affects thousands of people, being the third most prevalent in the world. Bevacizumab (BVZ) drug, already consolidated for other cancer treatments, exhibits limitations to oral administration because of it's proteic structure. In this way, the use of nanotechnology may help to search for new alternatives that are capable to improve BVZ biopharmaceutical characteri…
Colorectal cancer (CRC) is the third most common type of cancer in terms of incidence and the second most lethal in the world. Intravenous chemotherapy has been the therapeutic resource used in the treatment of cancer, however, the therapeutic effectiveness and the adverse effects are limited. compromise their use in this way. The colon-specific release of bevacizumab (BVZ) from nanostruc…
Glioblastomas (GBM) account 77% of malignant tumors that occurs on central nervous system (SNC) and today, despite all advances in chemotherapy, radiotherapy and neurosurgery, remains with limited prognosis. The existence of physiological barriers, especially blood brain barrier (BBB), represents the main obstacle that limits adequate concentrations of the drugs designed to therapy. Due t…
(Only some records are available in English at this moment)
| 5 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 30 / 22 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 9 / 9 | Completed scholarships abroad |
| 46 / 36 | All research grants and scholarships |
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