Abstract
Vascular relaxation signaling pathway involves several mediators. One of the major relaxing factors is nitric oxide (NO). It is produced by the enzymes nitric oxide synthases (NOS). Among the NOS isoforms: NOS-1 (neuronal), NOS-2 (inducible) and NOS-3 (endothelial), the present study will focus on NOS-3 (eNOS) as a cellular target. The NOS-1 and NOS-3 are constitutive enzymes and they dep…