Abstract
Epstein-Barr virus (EBV) can be found latently infecting Reed-Sternberg (RS) malignant cells in approximately 50% of classical Hodgkin lymphoma (cHL) patients in Brazil. EBV signaling leads to an unbalance between effector and regulatory CD4 T lymphocytes (Tregs) in the tumor microenvironment, promoting the immune evasion of RS malignant cells. Recently, our group showed that patients wit…