CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
DVM - Universidade de Brasília (2006). Master - Allergology and Clinical Immunology - UFMUSP (2009). PhD in Immunology - Universidade de São Paulo (2011). Post doctoral at the Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School. Professor in Immunology at the university of Campinas. The areas of research include: immunometabolism, diabetes and obesity. (Source: Lattes Curriculum)
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The gut microbiota and the innate and adaptive immune systems within the gastrointestinal tract are major contributors to host health, but their functional interactions within sex and across the lifespan remain incompletely defined. Defining the mechanisms by which gut microbial metabolites regulate host gut immune responses will improve our understanding of how to better leverage the gut…
The XFp96e analyzer simultaneously measures, in real time, the two main energy pathways of a cell, mitochondrial respiration and glycolysis in non-sensor-labeled cells, in microplate format. Thus, it is possible to isolate cells, such as different subtypes of macrophages, lymphocytes, adipocytes, among other cell types, and culture them in microplates to evaluate their metabolic profile. …
The growing interest in Immunometabolism is fueled by the global obesity epidemic and obesity-induced inflammation is a risk factor for several chronic pathologies and diseases. The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. Studies on macrophage metabolic adaptation largely relies in th…
(Only some records are available in English at this moment)
The biochemical of activities occurring in mitochondria are linked to mitochondria morphology. For example, the spatial segregation of biochemical pathways ultimately controls oxidative phosphorylation and energy generation. Systemic and tissue-derived cues shape mitochondria through fission/fusion events, which orchestrates how mitochondria will function. In the immune system, effector c…
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 700,000 people on all continents and has been responsible for more than 20,000 deaths worldwide (World Health Organization - official data of March 27, 2020). The only way to treat severe cases is through respiratory support with still unsatisfactory results. To date, there…
The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. The growing interest in Immunometabolism is fueled by the global obesity epidemic and the strong association between inflammation and metabolic disease. Obesity-induced inflammation is a risk factor for several chronic pathologies and diseas…
Macrophages are antigen presenting phagocytes that play a central role in the pathophisiology of many diseases. Their plasticity allows them to adopt pro (M1-like) or anti-inflammatory (M2-like) profiles depending on the surrounding cytokine and substrate microenvironment. This versatily relies on their capability to reprogramm cellular metabolism in order to supply its basal energetic de…
Adipose tissue can be divided into three major types: white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue (BeAT). BAT and BeAT generate heat by oxidizing fatty acids, while white adipocytes handle fat storage. Adaptative thermogenesis (Adaptative thermogenesis) produces heat through brown and beige adipocytes. During cold exposure BAT increases UCP1 expression…
Tbx21/T-bet is a transcription factor of the T-box binding domain protein family that was originally described in CD4 T cells and later in T CD8, NK, NKT and ILC1 cells, as being responsible for the transactivation of the Interferon (IFN)y gene, for Th1-type response maintenance. T-bet represses Gata3 and RoryT in helper T lymphocytes and induces IgG2c expression on B lymphocytes, all of …
(Only some records are available in English at this moment)
Pro-inflammatory macrophages, as those activated with LPS and INF-³ (³), are characterized by NF-ºB activation, pro-inflammatory cytokine induction (IL-1, IL-6, IL-12, TNF-±), and nitric oxide (NO) and reactive oxygen species (ROS) production. One source of ROS rapidly activated in phagocytes is NADPH-oxidase, regulated by NF-ºB, which directly controls gp91phox gene expression. M(LPS/³)…
Obesity is an epidemic disease and a major risk factor for cardiometabolic disorders. Different adipose depots contribute differently to the pathophysiology of Obesity. While accumulation of visceral fat is detrimental, subcutaneous fat is often neutral or beneficial. Many types of immune cells reside in Adipose Tissue (AT). Among them, macrophages are the most abundant and are essential …
(Only some records are available in English at this moment)
The recognition of bacterial components by macrophages triggers the production of inflammatory mediators, such as hydrogen peroxide (ROS), and cytokines, including TNF-a, IL-6, and IL-1b. This profile can be induced in macrophages activated with LPS plus IFN-a (M(LPS/y)) and depends on glucose metabolism and stabilization of hypoxia inducible factor-1a (HIF-1a). Glucose is necessary for N…
Macrophages are key cells for the maintenance of tissue homeostasis, for example, through phagocytosis of dead cells, which is an immunological "silent" process. By contrast, macrophages activated by pathogens are a primary host defense mechanism and via the production of oxygen and nitrogen radicals necessary to kill pathogens, can also damage tissues. ROS production causes oxidative dam…
Activation of the NLRP3 inflammasome follows a "two-step" route: priming and activation. It has been a consensus that the activation step involves a greater efflux of K+, however the mechanism by which the efflux of K+ induces the activation of the inflammasome is not clear yet. Recent studies have shown the essential role of mitochondrial stress in leaking ox-mtDNA into the cytoplasm to …
Macrophages are present in all tissues of vertebrates and play a key role in host defense and tissue homeostasis. During obesity, there is an accumulation of macrophages in adipose tissue (AT). Obesity milieu results in the production of pro-inflammatory cytokines (TNF-± and IL-1²) by AT macrophages (ATMs), leading to AT inflammation and subsequent insulin resistance. Although many propos…
Multiple sclerosis (MS) is considered a T-cell mediated autoimmune disease. Thus the study of the mechanisms that control the T cell response, as well as innovative strategies to modulate the pathways that control T-cell polarization by antigen-presenting cells (APCs) is likely to result in new therapeutic approaches. In this application we propose to study the mechanisms by which the tra…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 23 / 23 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 47 / 47 | All research grants and scholarships |
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