CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Over the course of my research career I have been extremely fascinated about the link between alterations on inflammatory state and metabolism. During my master?s (State University of Londrina, Brazil) I was focused in understand the protective role of non-steroids anti-inflammatory drugs (NSAIDs) on liver abnormalities triggered by insulin resistance associated to cancer cachexia. Later on my PhD (University of Sao Paulo, Brazil), I dedicated myself to unravel the properties of the palmitoleic acid (POA), in cellular biology and function of macrophages and hepatocytes from obese mice. This omega-7 fatty acid modulated macrophages polarization and protected the liver from insulin resistance and chronic inflammation associated with obesity. In a further mechanistic characterization, I observed the liver metabolic function were dependent of PPAR activation, but POA anti-inflammatory role occurred in whole liver or macrophages independently of PPAR nuclear receptors, PPAR and PPAR . Since 2018 I have started my postdoctoral training with Dr. Dayoung Oh (UT Southwestern, Dallas, TX) as my mentor and we are exploring the role of GPR92 on the type 2 diabetes induced by diet. GPR92 is a G-Protein Coupled Receptor highly expressed in immune cells and pancreas, which seems to have an important metabolic/anti-inflammatory role that needs to be further explored especially due to the drugability potential of this GPCR. (Source: Lattes Curriculum)
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Obesity and insulin resistance are related to glucose and fat acids metabolism hepatic alterations. The insulin resistance promotes transcription factors activation that elevates gluconeogenesis and fatty acids de novo hepatic production, inhibit glycogen synthesis and reduces glucose and fatty acids oxidation. This effect enhances free fatty acids circulation levels and induces triacylgl…
Chronic inflammation contributes to many human diseases and conditions. Often these may be related to diet suggesting that dietary components may either trigger or modify inflammatory responses. Cell culture systems offer controlled settings in which the effect of specific compounds, including nutrients, can be tested for their effects on inflammatory processes and their mechanisms of act…
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
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