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Camila Oliveira de Souza

CV Lattes

Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation from the last research proposal)
Birthplace: Brazil

Over the course of my research career I have been extremely fascinated about the link between alterations on inflammatory state and metabolism. During my master?s (State University of Londrina, Brazil) I was focused in understand the protective role of non-steroids anti-inflammatory drugs (NSAIDs) on liver abnormalities triggered by insulin resistance associated to cancer cachexia. Later on my PhD (University of Sao Paulo, Brazil), I dedicated myself to unravel the properties of the palmitoleic acid (POA), in cellular biology and function of macrophages and hepatocytes from obese mice. This omega-7 fatty acid modulated macrophages polarization and protected the liver from insulin resistance and chronic inflammation associated with obesity. In a further mechanistic characterization, I observed the liver metabolic function were dependent of PPAR activation, but POA anti-inflammatory role occurred in whole liver or macrophages independently of PPAR nuclear receptors, PPAR and PPAR . Since 2018 I have started my postdoctoral training with Dr. Dayoung Oh (UT Southwestern, Dallas, TX) as my mentor and we are exploring the role of GPR92 on the type 2 diabetes induced by diet. GPR92 is a G-Protein Coupled Receptor highly expressed in immune cells and pancreas, which seems to have an important metabolic/anti-inflammatory role that needs to be further explored especially due to the drugability potential of this GPCR. (Source: Lattes Curriculum)

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