Renata Sesti Costa
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Centro de Hematologia e Hemoterapia (HEMOCENTRO) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the Faculty of Philosophy, Sciences and Languages of Ribeirão Preto - University of São Paulo (2002). Held the master's and doctorate in Basic and Applied Immunology by the Ribeirão Preto Medical School - University of São Paulo, with emphasis on the study of Neuroimmunology (2005 and 2009). Postdoctoral developed in the Department of Pathology and Immunology of Washinghton University in St. Louis, MO, USA, under the supervision of Dr. Marco Colonna in the study of the functions of plasmacytoid dendritic cells (from 2013 to 2015). She is currently a postdoctoral fellow by the Ribeirão Preto Medical School - University of São Paulo, under the supervision of Dr. João Santana da Silva, where investigates the role of dendritic cells and their PRRs in Coxsackie virus infection. She has experience in the area of Immunology, with emphasis on infectious diseases (coxsackievirus, LCMV, Plasmodium berghei and Trypanosoma cruzi) and cellular immunity. (Source: Lattes Curriculum)
- Functional analysis of LXN gene in vitro and in vivo and genes global expression evaluation in primary erythroid culture after HbF induction through the compound decitabine, BP.PD
Abstract
LXN gene that encodes a latexina carboxipeptidases-inhibited showed increased expression in the intermediate and final stages of erythroid differentiation in previous results published by our group. The gene silencing in K562 was able to reduce the expression of alpha and gamma globins genes and HbF production after eritropoese induction. In vivo model, zebrafish embryos silenced for LX...
- Molecular mechanisms involved in dendritic cell differentiation and CD4+ t cells polarization that confer resistance to viral infection, BP.PD
Abstract
Dendritic cells (DC) are a heterogeneous group of cells divided in several subsets that, although share the common function of antigen presentation, they play distinct roles in immune response. Although it has been well studied the different cytokines and transcription factors that induce the development of the distinct subsets of DCs from monocytes and bone marrow precursors during hom...
- The role of IPS-1 and TRIF signaling in the in vivo dendritic cells differentiation and CD4+ t cell polarization during acute and chronic viral infection, BE.EP.PD
Abstract
The development of the distinct subsets of dendritic cells (DCs) from monocytes and bone marrow precursors during homeostasis is mediated by the different transcription factors expressed and the cytokines present in the microenvironment. A number of these cytokines and their receptors is up-regulated upon infection, which can influence the expansion and the differentiation of the prefor...
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SESTI-COSTA, RENATA; SANTIAGO FRANCOZO, MARCELA CRISTINA; SILVA, GRACE KELLY; PROENCA-MODENA, JOSE LUIZ; SILVA, JOAO SANTANA. TLR3 is required for survival following Coxsackievirus B3 infection by driving T lymphocyte activation and polarization: The role of dendritic cells. PLoS One, v. 12, n. 10, OCT 3 2017. Web of Science Citations: 5. (13/08216-2, 12/20786-6)