CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Bacharel Em Química from Universidade de São Paulo (1986), master's at Chemistry from Universidade de São Paulo (1991) and ph.d. at Chemistry from Universidade de São Paulo (1995). Has experience in Chemistry, focusing on Polymers and Colloids, acting on the following subjects: fluorescência, polieletrólitos, agregação, fotofísica and copolímeros. (Source: Lattes Curriculum)
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The Sars-Cov2 pandemic highlighted the great potential of therapeutic strategies involving gene therapy, mainly due to the development of vectors capable of delivering mRNA and siRNA molecules. Among the various polymers used in non-viral gene therapy, biodegradable low molar mass amphipathic polymers have shown great potential and generated several patents focusing on the release of mRNA…
Nowadays, the development of alternative therapies for the treatment of inflammatory diseases is an urgent need due to the high cost and limitation of the traditional treatments. In this subject the gene therapy via delivery of small interfering RNA is a promising approach when targeted to modulate the macrophages response, since they play major roles in many chronic diseases including at…
The treatment of diseases by means of gene therapy is becoming a reality, specially due to the massive investment on fundamental research about the understanding of the transfection mechanism and the barriers. The latter prevents effective steps of carrying, delivery and expression of genes. Among the vectors employed for this purpose the non-viral ones are very promising due to their gre…
O projeto propõe a síntese e estudo de derivados de quitosana como sistemas para obtenção de nano e micropartículas como potenciais vetores para liberação de agentes terapêuticos. O projeto será desenvolvido focalizando-se quitosana de diferentes massas molares, modificadas com diferentes grupos hidrofílicos. A escolha de quitosana se deve ao fato deste polímero ter se mostrado bastante p…
(Only some records are available in English at this moment)
The delivery of nucleic acids, such as mRNA and siRNA, represents a promising therapeutic approach for vaccines, cancer immunotherapy, and the treatment of genetic disorders. However, the clinical application of these biopolymers requires the development of efficient carriers capable of promoting nucleic acid complexation, protection, and intracellular release. This project proposes the s…
This project aims to develop multifunctional nanoparticles seeking the treatment of skin diseases and is based on previous studies. In this study will be used polymeric nanoparticles and hybrid gold-polycation nanoparticles for siRNA release to reduce the expression of cytokines (TNF-alpha and IL-17) associated with the development of Psoriasis, a chronic inflammatory disease that manifes…
This project aims to build efficient and site-specific nanodevices to the transport and release of siRNA for the development of an alternative treatment for rheumatoid arthritis. The proposal is based on previous in vitro results, obtained with nanoparticles prepared with biocompatible derivatives of chitosan (CH). The adjustment of composition provided an efficient intracellular release …
The main goal of this project is the synthesis and characterization of chitosan and chitosan-collagen scaffolds by varying the composition as well as pores sizes, degree of reticulation and wetability to provide the needed properties for adhesion and cell growth and proliferation.
(Only some records are available in English at this moment)
The first part of this project was dedicated to the synthesis and characterization of new derivatives of chitosan, focusing the improvement of the stability and buffering capacity of the nanoparticles. Derivatives were synthesized (CH-DEAE15-PEG, QO-DEAE9 and QDDEAE50) and characterized by 1H NMR, FTIR and gel permeation chromatography. The improvement of nanoparticle's stability was conc…