CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Biologist by the Universidade Federal do Pará, Brazil (Belém, 2007), PhD in Molecular Biology at the Universidad Autónoma de Madrid (Madrid, 2011). Worked as post-doctoral research at the CNB-CSIC (Madrid, 2012) on Systems and Synthetic Biology, and at the FMRP-USP (Riebirão Preto, 2015), working on Systems Biology. From 2015 to 2018 worked as Assistant Professor at the Cell and Molecular Biology Department at FMRP-USP. Since 2018 works as Associate Professor at the Cell and Molecular Biology Department at FMRP-USP, working on Systems and Synthetic Biology, Computational Biology and Bioinformatics. E-mail: silvarochar@gmail.com. HomePage: http://silvarochar.wixsite.com/ssbl. (Source: Lattes Curriculum)
| Articles published in other media outlets (1 total): |
| FolhaMT: Bactéria transgênica funciona com interruptor à base de aspirina (23/Aug/2019) |
Gene regulatory networks (GRNs) are the central control units determining the dynamics of living systems to changing environmental conditions. The recent advances in genomics and systems biology approaches have allowed the investigation of GRNs in at a resolution with no precedents. Yet, GRNs are combinatorial, where multiple signaling pathways acts together to control the large diversity…
We will examine how wild-type PA01 catabolises propionate (in comparison with succinate, a control substrate). This will be done by integrating data obtained from a combination of transcriptomic (RNA-Seq), metabolomic (1N NMR, GC-MS/MS and LC-MS) and proteomic (iTRAQ) analyses. The Welch team has expertise in RNA-Seq, metabolomic and proteomic analyses, whereas the Silva-Rocha team has ex…
The ability to coordinate expression of thousands of genes in response to different stimuli is an essential feature of any live organism. However, current knowledge on this matter is largely inferred from data on extant systems involving just a few regulatory components. In this context, this project propose the adoption of a genetically tractable experimental object (Escherichia coli) al…
The microbiota, a term that designates the set of microorganisms present in a given environment, has been gaining significant attention regarding its relationship with human health. The most used method for the characterization of microorganisms based on the sequencing results, both in environments such as rivers, water treatment plants or hospitals, and in human mucous membranes, is base…
The oleaginous and carotenogenic yeast Rhodosporidium toruloides is a promising host for the production of bioproducts from lignocellulosic biomass because it is able to efficiently consume C5 and C6 sugars and lignin-derived aromatic compounds. It also presents a high lipid concentration and a potential to store other compounds derived from acetyl-CoA, such as terpenes. Terpenes are a la…
Biofilms are complexes structures composite by different or similar bacteria that form communities, enclosed into a polymeric extracellular matrix (EPS), constituted by polysaccharides, proteins and nucleic acids. These structures are very present on the natural environment and exert an important role on ecologic and human life. Their formation regulatory networks are composite by environ…
(Only some records are available in English at this moment)
Pseudomonas aeruginosa is a bacterium often found in the environment and opportunistic pathogen associated with serious infections. This organism has a genome of more than 6 Mb which is controlled by sophisticated molecular machinery that includes ~25 sigma factors and hundreds of transcription factors. Although many studies have investigated several transcription factors related to the l…
The problem of antibiotic resistance has become a threat to global health. Increasingly, we are creating an atmosphere of selective pressure that has never been seen before by bacteria, due to either the use or misuse of antibiotics or any environmental contamination due to anthropological action. It is known that genes that confer resistance to antibiotics are both in pathogens and in en…
(Only some records are available in English at this moment)
Synthetic biology directed to biomedical applications aims to develop engineering-driven approaches to the programming of cellular functions that could yield transformative diagnostic tools, as well as unmatched therapeutic strategies for treating significant human pathologies. Our ability to generate bacterial strains with unique and increasingly complex functions has rapidly expanded in…
The sharing of genetic information among microbial communities can be represented by a complex network that interconnects the most diverse information, as for example: metabolites, specific genes, enzymes, substrates and also the transcription factors. For instance, the survival and coexistence of a microbial community could be explained or understood through genes expressed by that commu…
Plant biomass degradation has been studied for years due to the incredible amount of byproducts generated during this process - ranging from biofuels to other noteworthy chemicals. The candidate current master's project is dedicated on building modular vectors based on synthetic biology for the transformation of fungi, more specifically T. reesei. The interest in this fungus arose because…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 18 / 17 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 31 / 29 | All research grants and scholarships |
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