- Research Grants
I Graduated in Biological Sciences (BSc and BA) at the Universidade Estadual do Norte do Paraná (UENP) in 2010, being the bachelor's project developed at the Universidade Estadual Paulista (UNESP), which the project was aimed to study Elasmobranchii (sharks and rays) focused on forensic and conservation genetics. My Master Degree was obtained in 2012 in the Genetics Program at UNESP, working in a project focused on analyze the expression profile of muscle-specific microRNAs and their targets in skeletal muscle of Nile tilapia and to understand the genomic organization of these microRNAs among fish genomes. I finished my PhD in Genetics Program at UNESP last February. My PhD project aimed to understand the functional roles of microRNAs in cardiac development. Being two major objectives: (1) comparative analysis of microRNAs expressed in heart tissue of 23 species of vertebrates (from fish to mammals) provided by small RNA-seq; and (2) functional analysis of miR-129 and their targets along cardiac development by using zebrafish as the model. Currently, I am a Postdoctoral researcher at IME-USP, developing a computational predictive model to characterize regulatory genomic regions in metazoan species with high accuracy. Thus, my skills and capabilities are related to Bioinformatics (Comparative genomics and Transcriptome analysis), programming in R and Python, and molecular tools as qPCR, immunodetection (sectioned tissues and whole embryos), in situ hybridization, injection of morpholinos in zebrafish embryos, and development of transgenic zebrafish lineage by using the Tol2 approach. (Source: Lattes Curriculum)
Differences in venom composition produced by different snake species can result from distinct regulatory mechanisms occurring in each species. It is known that changes in expression levels of components of genetic regulatory networks are responsible for phenotypic differences. Recently, few studies showed that miRNAs can be related to modulation of the differential venom composition in ...
MicroRNAs (miRNAs) are small non-coding RNAs that play regulatory roles in plants and animals. These molecules inhibit translation through post-transcriptional regulation of messenger RNAs. In vertebrates, miRNAs have been linked to organismal evolution due to the observed correlation between abundance of miRNAs and complexity. Furthermore, miRNAs are key managers in the development and...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
NACHTIGALL, Pedro Gabriel. Genômica funcional de micrornas no coração de vertebrados zebrafish como organismo modelo. 2017. Tese (Doutorado) – . Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).