Abstract
The L-asparaginase (ASPase) was discovered in the 1960s and it is used until the present day as a leading biopharmaceutical to treat leukemia. It is an enzyme capable of catalyzing the cleavage of the amino acid asparagine (Asn) to form aspartic acid and ammonia. This prevents the uptake of extracellular Asn by tumor cells, causing decreased protein production and consequently a decrease …