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Alessandra Pontillo

CV Lattes ResearcherID ORCID

Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation for the last research proposal)
Birthplace: Itália

Since 2013 she is a professor at the Institute of Biomedical Sciences (ICB) of the University of São Paulo (USP), where she currently holds the position of Associate Professor in the Department of Immunology. Graduated in Biological Sciences (1999), PhD in Experimental and Clinical Pathology (2003) and Residency in Medical Genetics (2008) obtained from Universita Degli Studi Di Trieste (Italy). She did a post-doctorate at the Children's Institute "Burlo Garofolo" in Trieste ((Italy) from 2003 to 2011. Between 2011 and 2013 she was a visiting researcher in Brazil (at the LIM-56 at FMUSP and at the Genetics Department at UFPE). In 2021 she obtained the title of "Livre Docencia" by ICB / USP in the area of Immunogenetics. She has expertise in innate immunity and inflammation, inflammasome, autoinflammatory diseases, immunogenetics, medical and population genetics.She develops research projects related to human genetics of innate immunity and inflammation with particular interest in the multiprotein complex of the inflammasome. The analysis of the genes of interest both in autoinflammatory monogenic diseases and in multifactorial diseases with an established inflammatory component (autoinflammatory, autoimmune, infectious, neurodegenerative diseases, neoplasms) aims to contribute to the knowledge of the immunopathological mechanisms of these diseases and to identify alternative or new diagnostic markers targets of therapeutic intervention. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

DE LIMA, D. SOUZA; OGUSKU, M. M.; SADAHIRO, A.; PONTILLO, A.. Inflammasome genetics contributes to the development and control of active pulmonary tuberculosis. INFECTION GENETICS AND EVOLUTION, v. 41, p. 240-244, . Web of Science Citations: 6. (13/06142-1)

SANTOS, MARINA L. S.; REIS, EDIONE CRISTINA; BRICHER, PAMELA N.; SOUSA, TAIS N.; BRITO, CRISTIANA F. A.; LACERDA, MARCUS V. G.; FONTES, COR J. F.; CARVALHO, LUZIA H.; PONTILLO, ALESSANDRA. yy Contribution of inflammasome genetics in Plasmodium vivax malaria. INFECTION GENETICS AND EVOLUTION, v. 40, p. 162-166, . Web of Science Citations: 6. (13/06142-1)

MOURA, RONALD; PONTILLO, ALESSANDRA; D'ADAMO, PIO; PIRASTU, NICOLA; COELHO, ANTONIO CAMPOS; CROVELLA, SERGIO. Exome analysis of HIV patients submitted to dendritic cells therapeutic vaccine reveals an association of CNOT1 gene with response to the treatment. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, v. 17, . Web of Science Citations: 7. (13/06142-1)

PONTILLO, ALESSANDRA; DA SILVA, RONALDO C.; MOURA, RONALD; CROVELLA, SERGIO. Host genomic HIV restriction factors modulate the response to dendritic cell-based treatment against HIV-1. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 10, n. 2, p. 512-518, . Web of Science Citations: 7. (13/06142-1)

PONTILLO, A.; BRICHER, P.; LEAL, V. N. C.; LIMA, S.; SOUZA, P. R. E.; CROVELLA, S.. Role of Inflammasome Genetics in Susceptibility to HPV Infection and Cervical Cancer Development. Journal of Medical Virology, v. 88, n. 9, p. 1646-1651, . Web of Science Citations: 16. (13/06142-1)

DA SILVA, WANESSA CARDOSO; OSHIRO, TELMA M.; DE SA, DANIEL COELHO; FRANCO, DILCILEA D. G. S.; NETO, CYRO FESTA; PONTILLO, ALESSANDRA. Data on inflammasome gene polymorphisms of patients with sporadic malignant melanoma in a Brazilian cohort. DATA IN BRIEF, v. 10, p. 33-37, . Web of Science Citations: 1. (12/18448-5, 12/09824-3, 13/06142-1)

DE LIMA, DHEMERSON SOUZA; BOMFIM, CAIO C. B.; LEAL, VINICIUS N. C.; REIS, EDIONE C.; SOARES, JAINE L. S.; FERNANDES, FERNANDA P.; AMARAL, EDUARDO P.; LOURES, V, FLAVIO; OGUSKU, MAURICIO M.; D'IMPERIO LIMA, MARIA R.; et al. Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas. FRONTIERS IN IMMUNOLOGY, v. 11, . Web of Science Citations: 0. (15/20432-8, 15/23395-6, 15/50650-7)

CORDEIRO LEAL, VINICIUS NUNES; REIS, EDIONE CRISTINA; FERNANDES, FERNANDA PEREIRA; DA SILVA SOARES, JAINE LIMA; COSTA OLIVEIRA, IOHANA GABRIELY; DE LIMA, DHEMERSON SOUZA; LARA, AMANDA NAZARETH; LOPES, MARTA HELOISA; PONTILLO, ALESSANDRA. Common pathogen-associated molecular patterns induce the hyper-activation of NLRP3 inflammasome in circulating B lymphocytes of HIV-infected individuals. AIDS, v. 35, n. 6, p. 899-910, . Web of Science Citations: 1. (18/04361-1, 15/17373-0, 17/10824-1, 15/50650-7, 15/23395-6)

REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, . Web of Science Citations: 0. (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)

DE LIMA, DHEMERSON SOUZA; NUNES, VINICIUS C. L.; OGUSKU, MAURICIO M.; SADAHIRO, AYA; PONTILLO, ALESSANDRA; ALENCAR, BRUNA DE CUNHA. Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1 beta. INFECTION GENETICS AND EVOLUTION, v. 55, p. 313-317, . Web of Science Citations: 2. (15/23395-6, 14/23225-0, 13/06142-1)

REIS, EDIONE C.; DA SILVA, LAIS T.; DA SILVA, WANESSA C.; RIOS, ALEXANDRE; DUARTE, ALBERTO J.; OSHIRO, TELMA M.; CROVELLA, SERGIO; PONTILLO, ALESSANDRA. Host genetics contributes to the effectiveness of dendritic cell-based HIV immunotherapy. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 14, n. 8, p. 1995-2002, . Web of Science Citations: 2. (15/23395-6, 17/22131-0, 13/06142-1)

RODRIGUES, JULIANA DE MORAES; DE LIMA, DHEMERSON SOUZA; LEAL, VINICIUS N. C.; BOSCO, ADRIANA A.; SANDRIM, VALERIA; PONTILLO, ALESSANDRA. Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?. ENDOCRINE, v. 60, n. 2, p. 368-371, . Web of Science Citations: 0. (15/23395-6)

DA SILVA, WANESSA CARDOSO; OSHIRO, TELMA MIYUKI; DE SA, DANIEL COELHO; FRANCO, DILCILEA D. G. S.; NETO, CYRO FESTA; PONTILLO, ALESSANDRA. Genotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression. CANCER GENETICS, v. 209, n. 10, p. 474-480, . Web of Science Citations: 8. (12/18448-5, 12/09824-3, 13/06142-1)

GOMES DOS SANTOS, ALEXANDRA; WATANABE, ELIESER HITOSHI; FERREIRA, DAIANE TOMOMI; OLIVEIRA, JAMILLE; NAKANISHI, ERIKA SHIMODA; OLIVEIRA, CLAUDIA SILVA; BOCCHI, EDIMAR; NOVAES, CRISTINA TERRA GALLAFRIO; CRUZ, FATIMA; CARVALHO, NOEMIA BARBOSA; et al. A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease. FRONTIERS IN IMMUNOLOGY, v. 11, . Web of Science Citations: 0. (19/06363-4, 12/50273-0)

SOARES, JAINE L. S.; OLIVEIRA, ENEDINA M. L.; PONTILLO, ALESSANDRA. Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS, v. 29, p. 26-34, . Web of Science Citations: 3. (15/23395-6, 15/50650-7)

DOS REIS, EDIONE CRISTINA; CORDEIRO LEAL, VINICIUS NUNES; DA SILVA SOARES, JAINE LIMA; FERNANDES, FERNANDA PEREIRA; DE LIMA, DHEMERSON SOUZA; DE ALENCAR, BRUNA CUNHA; PONTILLO, ALESSANDRA. Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals. FRONTIERS IN IMMUNOLOGY, v. 10, . Web of Science Citations: 2. (17/10824-1, 18/04361-1, 15/23395-6, 14/23225-0, 15/17373-0)

REIS, EDIONE C.; LEAL, VINICIUS N. C.; DA SILVA, LAIS T.; DOS REIS, MARILIA M. L.; ARGANARAZ, ENRIQUE R.; OSHIRO, TELMA M.; PONTILLO, ALESSANDRA. Antagonistic role of IL-1 beta and NLRP3/IL-18 genetics in chronic HIV-1 infection. Clinical Immunology, v. 209, . Web of Science Citations: 1. (15/23395-6, 15/50650-7, 13/06142-1)


SOARES, JAINE L. S.; FERNANDES, FERNANDA PEREIRA; PATENTE, THIAGO ANDRADE; MONTEIRO, MARIA B.; PARISI, MARIA C.; GIANNELLA-NETO, DANIEL; CORREA-GIANNELLA, MARIA L.; PONTILLO, ALESSANDRA. Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease: NLRP1 inflammasome role in metabolic stress sensing?. Clinical Immunology, v. 187, p. 46-49, . Web of Science Citations: 6. (15/23395-6, 09/09276-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERNANDES, Fernanda Pereira. Avaliação da ativação do inflamassoma no contexto da infecção por HPV e do câncer cervical associado ao HPV. Dissertação (Mestrado) -  Faculdade de Medicina.  Universidade de São Paulo (USP).  São Paulo.  (18/04361-1

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