Adjunct Professor in the Department of Biophysics at UNIFESP, he obtained the title of Doctor in Physics (2011) from the Universities of São Paulo and Bordeaux (France) with a thesis on the structure and dynamics of DNA intercalated in lamellar phases of lipids. During his doctorate, he was a scholarship holder of the Eiffel-Egide Excellence Scholarship Programme. He has experience in biophysical methods focused on the structural characterization of self-organized systems of biomolecules, including spectroscopic techniques, microscopy methods, and low-angle scattering tools (X-rays and neutrons). He was a postdoctoral fellow at UFABC, where he studied self-organized systems based on amphiphilic peptides. Between May 2014 and May 2015, he was a visiting researcher in the Department of Chemistry at the University of Reading, United Kingdom. He was a visiting professor at the Institute of Physics of the Federal University of Alagoas. Currently, he coordinates the Structural Biophysics Laboratory in the Department of Biophysics at the Paulista School of Medicine at UNIFESP. He is a full member of the Brazilian Physics Society (SBF), the Brazilian Biophysics Society (SBBf), and Sigma Xi, The Scientific Research Honor Society (USA). (Source: Lattes Curriculum)
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This Multi-User Equipment (EMU) project aims at installing an Atomic Force Microscope (AFM) at the São Paulo campus of the Federal University of São Paulo (UNIFESP). The AFM is a scanning probe instrument that allows obtaining data from interfaces at the nanoscale. It enables, among other applications, the acquisition of surface topography of various materials, from rigid substrates to ce…
Nanostructured matrices obtained from the self-organization of biomolecules are a promising class to formulate the next generation of biomaterials. In this context, three-dimensional scaffolds consisting of nanoscale fibrillar networks that mimic the biological environment are among the most attractive systems for biotechnological applications. Obviously, detailed knowledge of the spatia…
Nucleic acids and peptides occupy a privileged position in the spectrum of materials intended for the fabrication of bionanostructures. These molecular species exhibit high physicochemical versatility along with intrinsic biocompatibility. Inspired by these unique properties, in this project we aim to formulate nanostructured materials based on self-assembling bioactive peptides and nucl…
In the late 1980's, researches related to HIV conducted to the surprising discovery that certain protein domains are able to cross eukaryotic membranes. These short sequences, usually containing between 5 and 40 amino acids, were quickly called cell-penetrating peptides (CPPs) and their potential for designing synthetic vectors suitable for gene therapy was immediately recognized. Current…
We describe in depth the structure of complexes formed between DNA and two classes of arginine-containing peptide amphiphiles, namely, the lipopeptide PRW-C16 (P = proline, R = arginine, W = tryptophan, C16 = C16 : 0 alkyl chain) and the bolaamphiphile RFL4FR (R = arginine, F = phenylalanine, L = leucine). A combination of X-ray and neutron scattering provided unprecedented insights into …
This project aims to produce and characterize novel nanostructured scaffolds obtained from self-assembling bioactive peptides. Our focus will be on sequences belonging to three major classes of bioactive compounds: cell penetrating peptides, constituents of extracellular matrix (collagen- and elastin-like sequences) and anti-inflammatory peptides. We will seek for answers to fundamental q…
We propose the synthesis and characterization of new peptide nanostructures obtained from self-assembly reactions. Inedited peptide sequences of bola-amphiphile and lipopeptide type will be prepared. The choice of these classes relies on the rich polymorphism of mesophases they are able to form and on their ability to establish biointerfaces through molecular recognition, increasing their…
Biomolecular condensates are a common phenomenon in biological matter, playing a crucial role in proper cellular functioning. This phenomenon appears when spontaneous phase separation occurs in equilibrium in a liquid environment, typically triggered by the mixing of biomolecules with opposite charges in aqueous medium. In addition, they may serve as an intermediate step in the formation …
This Project aims to produce and characterize nanostructured scaffolds based on the self-assembly of peptides belonging to three major classes of bioactive compounds: cell-penetrating peptides (CPPs), constituents of the extracellular matrix (ECM), and anti-inflammatory peptides (AIPs). The supramolecular architectures investigated here are original, and their bioactive characteristics op…
We propose the synthesis and characterization of new peptide nanostructures obtained from self-assembly processes. Novel peptide sequences, of bolamphiphile and lipopeptide type, will be prepared. The choice for these classes relies on the rich polymorphism of mesophases that they are able to form and on their ability to establish biointerfaces through molecular recognition, which increas…
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 11 / 10 | All research grants and scholarships |
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CV Lattes
ORCID