Abstract
The proopiomelanocortin (POMC) is a prohormone of 241 amino acids mainly produced by the pituitary. After processing it results at various peptides such as adrenocorticotrophic hormone (ACTH). Studies with animals POMC - / -showed that animals which survive to adulthood are obese, with pigmentation defects and severe adrenal insufficiency, reflecting the dependency of the POMC derived pep…