CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia-Bioquímica from Universidade de São Paulo (2013) and doctorate at Chemistry from Universidade de São Paulo (2020). Has experience in Chemistry (Source: Lattes Curriculum)
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In mammals, formation and detoxification of oxidized lipids are catalysed, among other enzymatic systems, by lipoxygenases and peroxidases, respectively. Some human lipoxygenases, including 5-lipoxygenase (5-LOX) and 15-lipoxygenases (15-LOX-1 and 15-LOX-2), participate in the biosynthesis of pro-inflammatory and pro-resolution lipid mediators and play important roles as modulators of inf…
Over decades, drug discovery has changed from non-systematic methods, based on serendipitous findings, to modern methodological strategies using different rational drug design approaches, which include Ligand Based Drug Design (LBDD) and Structure Based Drug Design (SBDD) approaches. One major example of this latter strategy is Virtual Screening (VS) of potential bioactive compounds (liga…
Ecto-5'-nucleotidase (ecto-5'NT, CD73) is a Zn2+-binding glycosylphosphatidylinositol (GPI)-anchored homodimeric enzyme, which hydrolyses AMP to adenosine, acting as a major control point for the extracellular provision of this signalling molecule. Human ecto-5'NT has been found to be expressed by several types of tumour cells, triggering immunosuppressive pathways in the tumour microenvi…
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