Mariana Kiomy Osako in research grants and scholarships supported by FAPESP.
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The operational unit bone-muscle refers to the mechanical interaction responsible for both bone and muscle and also to the communication via soluble factors that reciprocally regulate bone and muscle metabolism. RANKL (receptor activator of NFkB ligand) and OPG (osteoprotegerin) are examples of osteokynes that together with RANK (receptor activator of NFkB) are essential for osteoclast ac…
High serum osteoprotegerin (OPG) level has been associated with type 2 diabetes mellitus (T2DM), vascular calcification and predicts cardiovascular outcomes, but the biological explanation for the rise of OPG level remains unclear. OPG is a decoy receptor of RANKL, and the binding results in inhibition of RANKL activation of the membrane bound RANK. We have reported the contribution of th…
During the outbreak of COVID-19 by the SARS-CoV-2 virus, a high prevalence of severe acute respiratory syndrome was observed in overweight and obese patients, who also had a higher rate of hospitalization and admission to intensive care units. Obese patients show a greater risk of developing more severe forms of COVID-19; therefore, this project aims to elucidate the interactions between …
SARS-CoV-2 is the pathogenic agent of COVID-19, a disease responsible for more than 5 million deaths in the world until the moment, with more than 360 million cases reported. An essential clinical aspect observed in patients with the disease is the more significant risk of complications associated with obesity cases. It has already been described that SARS-CoV-2 could infect the adipose t…
The bone-muscle operational unit refers to the mechanical interaction between bone and muscle and the communication via soluble factors that reciprocally regulate their metabolism. RANKL (receptor activator of NFkB ligand) and OPG (osteoprotegerin) are examples of bone-specific proteins that, together with RANK (receptor activator of NFkB), are essential for osteoclast activation and bone…
The brown adipose tissue has been a novel target in different studies regarding its roles in thermogenesis. It is characterized by a high mitochondria density, that has its biogenesis regulated by PGC-1 family genes, in special by PGC-1±. PGC-1± is a co-transcriptional regulator factor, being responsible by a higher activity of PPAR³, regulating different metabolic pathways in the differe…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 10 | Completed scholarships in Brazil |
| 16 / 14 | All research grants and scholarships |
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