CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
PhD in Sciences from the Institute of Chemistry of São Carlos, University of São Paulo (2015). Between 2006 and 2010 Dr. Dores-Silva acquired extensive experience in the field of analytical chemistry during the scientific initiation, highlighting the purification and structural characterization of macro-biomolecules in soil and organic fertilizers. He obtained mastery of techniques such as: ultraviolet in the UV-Vis region, infrared, fluorescence and pyrolysis coupled to mass spectrometry. During his PhD at the University of São Paulo in the area of Biochemistry with emphasis on the production and purification of recombinant proteins, as well as biophysical techniques of structural and functional characterization, among them: circular dichroism (CD) fluorescence, analytical molecular exclusion chromatography, analytical ultracentrifugation (AUC), low-angle X-ray scattering (SAXS) differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC). He currently develops postdoctoral studies aiming at obtaining structural and functional data of molecular chaperones of the Hsp70 family, membranes and beta amyloid oligomerization. (Source: Lattes Curriculum)
The Human mitochondrial Hsp70 (mtHsp70, also known as mortalin) is involved in a range of cellular processes, where it has paradox roles: while it helps keeping cellular homeostasis, its malfunction is involved in degenerative disorders. In the mitochondrion matrix, mortalin acts in the process of protein importation from cytoplasm; in the cytoplasm, it may works as a p53 scavenger, there…
Heat shock proteins (Hsps) are important components of the cellular chaperone pool, playing an important role in the protein folding, intracellular traffic, degradation and assisting proteins to obtain their native structure, etc. Having around 40-60% of identity among its prokaryotic and eukaryotic members, the Hsp70 superfamily corresponds to a family of proteins highly conserved. In hu…
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 2 / 2 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 6 |
| Citations | 8 |
| Cit./Article | 1.3 |
| Data from Web of Science | |
BATISTA, FERNANDA A. H.; DORES-SILVA, PAULO R.; BORGES, JULIO C.. Molecular Chaperones Involved in Protein Recovery from Aggregates are Present in Protozoa Causative of Malaria and Leishmaniasis. CURRENT PROTEOMICS, v. 16, n. 1, p. 12-21, 2019. Web of Science Citations: 0. (14/07206-6, 14/16646-0, 12/50161-8, 11/23110-0)
DORES-SILVA, P. R.; BELOTI, L. L.; MINARI, K.; SILVA, S. M. O.; BARBOSA, L. R. S.; BORGES, J. C.. Structural and functional studies of Hsp70-escort protein-Hep1-of Leishmania braziliensis. International Journal of Biological Macromolecules, v. 79, p. 903-912, AUG 2015. Web of Science Citations: 4. (14/07206-6, 11/23110-0, 14/16646-0)
DORES-SILVA, PAULO ROBERTO; CAUVI, DAVID M.; KIRALY, VANESSA T. R.; BORGES, JULIO C.; DE MAIO, ANTONIO. Human HSPA9 (mtHsp70, mortalin) interacts with lipid bilayers containing cardiolipin, a major component of the inner mitochondrial membrane. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1862, n. 11, NOV 1 2020. Web of Science Citations: 0. (16/22477-1, 17/07335-9, 14/16646-0, 12/50161-8)
KIRALY, VANESSA T. R.; DORES-SILVA, PAULO R.; SERRAO, VITOR H. B.; CAUVI, DAVID M.; DE MAIO, ANTONIO; BORGES, JULIO C.. Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies. International Journal of Biological Macromolecules, v. 146, p. 320-331, MAR 1 2020. Web of Science Citations: 0. (17/26131-5, 14/07206-6, 11/23110-0, 12/50161-8, 17/07335-9, 14/16646-0)
DORES-SILVA, PAULO R.; NISHIMURA, LETICIA S.; KIRALY, VANESSA T. R.; BORGES, JULIO C.. Structural and functional studies of the Leishmania braziliensis mitochondrial Hsp70: Similarities and dissimilarities to human orthologues. Archives of Biochemistry and Biophysics, v. 613, p. 43-52, JAN 1 2017. Web of Science Citations: 2. (12/50161-8, 14/16646-0, 14/07206-6, 11/23110-0)
DORES-SILVA, PAULO ROBERTO; CAUVI, DAVID M.; COTO, AMANDA L. S.; KIRALY, VANESSA T. R.; BORGES, JULIO C.; DE MAIO, ANTONIO. Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain. CELL STRESS & CHAPERONES, v. 25, n. 6, JUL 2020. Web of Science Citations: 2. (12/50161-8, 14/16646-0, 17/26131-5, 16/22477-1, 17/07335-9)