CV Lattes
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Universidade do Oeste Paulista (UNOESTE). Pró-Reitoria de Pesquisa e Pós-Graduação (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Floriano obtained a degree in Biological Sciences (2001-2004) and a Masters degree in Animal Science (2006-2008) from the University of Western São Paulo (UNOESTE, Presidente Prudente, SP). He earned his PhD in Pharmacology (2010-2014) from the State University of Campinas (UNICAMP, Campinas, SP), completing a sandwich doctorate (2013-2013) at the Strathclyde Institute of Pharmacy and Biomedical Sciences from University of Strathclyde (SIPBS, Glasgow, Scotland). Following this, he secured his first postdoctoral position in Pharmacology (2015-2018) at UNICAMP and SIPBS. Currently, Dr. Floriano holds the position of Academic Visitor (2025-2026) in the Neurosciences Laboratory at SIPBS, supported by the São Paulo Research Foundation (FAPESP, São Paulo, SP). His research focuses on the structural and pharmacological characterization of bioactive components of animal venoms, including investigations into synthetic enzyme inhibitors as potential complementary therapies to antivenoms. He serves as a Permanent Professor in the Stricto Sensu Postgraduate Programs in Health Sciences and Animal Science at UNOESTE, where he is also a Full Professor of Pharmacology, Biotechnology, and Tissue Biology in the Undergraduate Program in Biomedicine. (Source: Lattes Curriculum)
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Envenomation by lancehead snakes (genus Bothrops) is characterized by cardiovascular effects (coagulopathy, systemic hemorrhage, hypotension/shock and acute kidney injury) mediated by enzymes such as L-amino acid oxidases, C-type lectins, serine proteinases, metalloproteinases and phospholipases A2 (PLA2), with the some of the latter acting as b-neurotoxins to cause presynaptic neuromuscu…
Accidents caused by snakes of the genus Bothrops induce severe clinical manifestations such as local and systemic myonecrosis, renal dysfunction, hemorrhage, coagulopathy, and hypotension. The treatment for envenomation by Bothrops spp. is restricted to polyvalent serotherapy. B. alternatus (Urutu-Cruzeiro) venom exhibits peculiar neurotoxic action in rodent nerve-muscle preparation in vi…
Envenomation by Lachesis is characterized by clinical manifestations such as local and systemic myonecrosis, renal dysfunction, hemorrhage, coagulopathy, and hypotension. The treatment for envenomation by Lachesis is conditioned to serotherapy and there are few reports related to application of other therapeutics pathways. Recent studies have shown that marimastat, a metalloprotease synth…
Envenomation by Crotalus (rattlesnakes) is characterized by clinical manifestations such as local and systemic myonecrosis, neuromuscular paralysis, renal injury, hemorrhage, coagulopathy, and hypotension. In Brazil, the treatment for crotales envenomation is conditioned to antivenom produced from the subspecies C. durissus terrificus venom (distributed in South and Southeastern regions o…
(Only some records are available in English at this moment)
Bothrops bilineatus smaragdinus (Viperidae: Crotalinae) venom induces two phenomena in mammalian nerve-muscle preparation: 1) neuromuscular facilitation, mediated by a peptide fraction (P8), immediately followed by 2) irreversible neuromuscular blockade, mostly mediated by a presynaptically active fosfolipase A2 (Bbil-TX). The toxinology of the P8 fraction of this venom has not been syste…
Coral snake (Micrurus spp.) venoms are known primarily for their neurotoxicity, which is mediated primarily by alpha-neurotoxins with postsynaptic activity and beta-neurotoxins (neurotoxic phospholipases - PLA2) with presynaptic activity. Preliminary studies have shown that venom of the coral snake Micrurus lemniscatus lemniscatus exerts presynaptic activity involving at least two PLA2 ne…
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| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 14 / 12 | All research grants and scholarships |
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