CV Lattes
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Universidade do Oeste Paulista (UNOESTE). Pró-Reitoria de Pesquisa e Pós-Graduação (Institutional affiliation for the last research proposal) Birthplace: Brazil
Rafael S. Floriano is graduated in Biological Sciences (2004) and M.Sc. in Animal Science (2008) at Universidade do Oeste Paulista (Presidente Prudente/SP/Brazil). He completed his Ph.D. in Pharmacology (2014) at Universidade Estadual de Campinas (Campinas/SP/Brazil) that included a research internship at Strathclyde Institute of Pharmacy and Biomedical Sciences (University of Strathclyde, Glasgow/UK). Dr. Floriano achieved his post-doctorate in Pharmacology at Universidade Estadual de Campinas (Campinas/SP/Brazil) and Institute of Pharmacy and Biomedical Sciences (University of Strathclyde, Glasgow/UK) from late 2015 until early 2018. His scientific production is based on the pharmacological characterization of bioactive compounds from animal venoms. His academic experience covers the disciplines of Human Physiology, Pharmacology, Toxicology, Biochemistry, Biophysics, Genetics, Biotechnology, Cell Biology and Histology. Dr. Floriano occupies the position of titular professor in the post-graduation program on Health Sciences of the Universidade do Oeste Paulista (Presidente Prudente/SP/Brazil). (Source: Lattes Curriculum)
Envenomation by lancehead snakes (genus Bothrops) is characterized by cardiovascular effects (coagulopathy, systemic hemorrhage, hypotension/shock and acute kidney injury) mediated by enzymes such as L-amino acid oxidases, C-type lectins, serine proteinases, metalloproteinases and phospholipases A2 (PLA2), with the some of the latter acting as b-neurotoxins to cause presynaptic neuromuscu…
Envenomation by Lachesis is characterized by clinical manifestations such as local and systemic myonecrosis, renal dysfunction, hemorrhagic, coagulopathic and hypotensive activities. The treatment of envenomation by Lachesis is conditioned to serotherapy and there are few reports related to application of other therapeutics pathways. Recent studies have shown that varespladib (LY315920), …
Envenomation by Lachesis is characterized by clinical manifestations such as local and systemic myonecrosis, renal dysfunction, hemorrhagic, coagulopathic and hypotensive activities. The treatment of envenomation by Lachesis is conditioned to serotherapy and there are few reports related to application of other therapeutics pathways. Recent studies revealed that n-acetylcysteine (NAC) can…
Coral snake (Micrurus spp.) venoms are well-known for their neurotoxicity mediated primarily by a-neurotoxins that act postsynaptically and b-neurotoxins (neurotoxic phospholipases - PLA2) that act presynaptically. Among the Micrurus spp. that have been screened for neurotoxicity, the venom of M. lemniscatus lemniscatus is of particular interest because of its strong presynaptic activity…
Coral snake (Micrurus spp.) venoms are known primarily for their neurotoxicity, which is mediated primarily by alpha-neurotoxins with postsynaptic activity and beta-neurotoxins (neurotoxic phospholipases - PLA2) with presynaptic activity. Preliminary studies have shown that venom of the coral snake Micrurus lemniscatus lemniscatus exerts presynaptic activity involving at least two PLA2 ne…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 6 / 6 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FLORIANO, RAFAEL S.; SCHEZARO-RAMOS, RAPHAEL; SILVA, JR., NELSON J.; BUCARETCHI, FABIO; ROWAN, EDWARD G.; HYSLOP, STEPHEN. Neurotoxicity of Micrurus lemniscatus lemniscatus (South American coralsnake) venom in vertebrate neuromuscular preparations in vitro and neutralization by antivenom. ARCHIVES OF TOXICOLOGY, v. 93, n. 7, p. 2065-2086, JUL 2019. Web of Science Citations: 0. (14/24409-8)