Abstract
The multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant genetic disease caused by germline mutations in the MEN1 gene or, more rarely, by germline mutations in other genes (CDKN2B/CDKN2C/CDKN1A/CDKN1B/AIP). MEN1 is associated with high predisposition to the development of endocrine and non-endocrine tumors, mainly, involving tumors in parathyroid and pituitary glands and e…