Alberto Fernando Oliveira Justo

• Abstract

  Late-onset depression is a condition characterized as Major Depressive Disorder that first occurs in individuals aged 60 years or older and presents symptoms such as anhedonia and depressed mood throughout most of the day. Depression has also been recognized as an important and unconventional factor for the development of cardiovascular and cerebrovascular diseases, although it is not cle…

  Association between intracranial atherosclerosis and late-life depression: a clinicopathological study, BP.IC

• Abstract

  Alzheimer's Disease (AD) is a progressive neurodegenerative disease, being the most frequent cause of dementia worldwide. Around 50 million people is estimated to have AD or other dementias and this number tends to double every 20 years. Although the etiology of the disease is partially explained by the deposition of aggregated forms of ²-amyloid proteins and neurofibrillary tangles in th…

  THE ROLE OF NITRIC OXIDE SYNTHASES IN ALZHEIMER'S DISEASE, BP.PD

• Abstract

  Corpora cavernosa from humans and other mammals relax to transmural stimulation, and these relaxations are sensitive to voltage-gated sodium channel blockers such as tetrodotoxin (TTX). Snakes and lizards are unique among amniote vertebrates in having a bilaterally symmetrical intromitteny penis, known as hemipenises. The transmural stimulation of Crotalus durissus terrificus hemipenises …

  Pharmacological, eletrophysiological and morphological characterization of a novel tetrodotoxin-resistant sodium channel coupled to corpus cavernosum of snakes, BP.DD

(Only some records are available in English at this moment)

• Abstract

  The phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) on Tyr81 was shown to increase NO production and blood vessel relaxation in response to agonist stimulation. Although Src has been initially reported to phosphorylate this tyrosine residue, the regulation of the phosphorylation of this site remains largely unexplored. Preliminary work at the Institute for Vascular Signal…

  Study of the regulation of eNOS Tyr81 phosphorylation, BE.EP.DD