Elizabeth Bilsland
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Has a PhD in Cell and Molecular Biology - Göteborg University , Sweden (2004 ) and post- doctorate in Biochemistry at the University of Cambridge ( United Kingdom - 2004 to 2015 ) . Is currently assistant professor in the Department of Structural and Functional Biology (Cell Biology area) Institute of Biology , State University of Campinas (UNICAMP). Has experience in genetics and biochemistry with emphasis on synthetic biology. Uses Saccharomyces cerevisiae as a platform for the discovery of new drugs. This includes the genetic engineering of various metabolic pathways of the yeast for screenings on a large scale . Develops modulators of heterologous metabolic pathways in yeast works on the identification of new compounds with antiparasitic activity, performs chemical-genomic profiling for the indentification of mode of action of natural compounds with antiviral, antibacterial or antiparasitic activity, and works on the identification of cellular drug import mechanisms. (Source: Lattes Curriculum)
- Engineering yeast cells for drug discovery, AP.JP
Abstract
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs though the blood brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as a platform for studying the transport of chemicals into and out of cells. We will construct yeast strains with de...
- Cloning and characterization of 10 human blood-brain-barrier transporters, BP.IC
Abstract
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs though the blood brain barrier.In this project, we aim to use the yeast Saccharomyces cerevisiae as a platform for studying the transport of chemicals into and out of cells. To that end the scientific initiation st...
- Determination of substrate specificity of plasma membrane transporters from Saccharomyces cerevisiae and Homo sapiens, BP.DR
Abstract
Drugs need to reach their targets (present on the surface or inside the cells) in order to function. Traditionally the pharmaceutical industry has designed new compounds assuming that they would enter the cell by passive diffusion through the plasma membrane, however, there is a growing body of evidence indicating that passive diffusion entry is the exception rather than the rule. Studi...
- Identification of plasma membrane import routes of Tau, FUS and alpha-synuclein disaggregating compounds using yeast based high-content screening, BE.EP.DR
Abstract
The drug development for diseases that affect the Central Nervous System (CNS) should consider the transport of the compound through the human Blood Brain Barrier (BBB). Due to the protective function of this barrier, the entrance of xenobiotic molecules is restricted and occurs preferentially via membrane carriers present in the BBB cells. Hence, the development of methodologies for th...
*Updated May 25, 2019
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 5 / 5 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 13 |
| Cit./Article | 4.3 |
| Data from Web of Science | |
BILSLAND, ELIZABETH; TAVELLA, TATYANA A.; KROGH, RENATA; STOKES, JAMIE E.; ROBERTS, ANNABELLE; AJIOKA, JAMES; SPRING, DAVID R.; ANDRICOPULO, ADRIANO D.; COSTA, FABIO T. M.; OLIVER, STEPHEN G.. Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons. BMC Biotechnology, v. 18, APR 11 2018. Web of Science Citations: 2. (15/03553-6, 12/16525-2)
BILSLAND, ELIZABETH; VAN VLIET, LIISA; WILLIAMS, KEVIN; FELTHAM, JACK; CARRASCO, MARTA P.; FOTORAN, WESLEY L.; CUBILLOS, ELIANA F. G.; WUNDERLICH, GERHARD; GROTLI, MORTEN; HOLLFELDER, FLORIAN; et al. Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan. SCIENTIFIC REPORTS, v. 8, JAN 18 2018. Web of Science Citations: 4. (15/03553-6, 12/23306-5, 15/19103-0)
BILSLAND, ELIZABETH; BEAN, DANIEL M.; DEVANEY, EILEEN; OLIVER, STEPHEN G.. Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi. PLoS Neglected Tropical Diseases, v. 10, n. 1, JAN 2016. Web of Science Citations: 7. (15/19103-0)