CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a degree in agricultural engineering (ESALQ - USP - 1995), a PhD in Cellular and Molecular Biology - Göteborg University, Sweden (2004) and a post-doctorate in Biochemistry at the University of Cambridge (United Kingdom - 2004 to 2015). Is currently assistant professor at the Department of Structural and Functional Biology (area of #8203;#8203;cell biology) of the Institute of Biology of the State University of Campinas. Established the Laboratory of Synthetic Biology (LaBS), where molecular biology, genetics, microbiology and biochemistry are combined to search for new antimicrobials, antiparasitics and for the engineering of stress-resistant yeasts. LaBS uses the yeast Saccharomyces cerevisiae and bacteria (E. coli, Bacillus, Streptomyces and Komagataeibacter) as a platform for the discovery of new drugs and biotechnological solutions. (Source: Lattes Curriculum)
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The current global energy matrix continues to rely heavily on fossil fuel-based energy sources, leading to increased impact on climate change. Increase awareness of the problem has led to a major shift towards developing cleaner and renewable technologies. In this context, microbial cellular platforms have been engineered to efficiently produce biofuels and biochemicals from lignocellulos…
The evolution of drug resistant malaria parasites coupled with the scarcity of new drugs, urge for discovery of new antimalarials. However, developing a brand new drug is a lengthy and costly process, due to bottlenecks in both the discovery and the therapeutic development (clinical trials) phases. Drug repositioning, which is the application of known and approved drugs and compounds to t…
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs though the blood brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as a platform for studying the transport of chemicals into and out of cells. We will construct yeast strains with dele…
In 2022 Brazil was the country that most used pesticides in the world, approximately 801 thousand tons of the product were applied to cultivated areas. These substances are harmful due to their own formulation and also due to their residues being difficult to degradate, promoting soil infertility and contamination of living beings and the environment. Furthermore, the use of chemical pest…
Violacein is a natural compound with antibacterial, antiparasitic and antitumor activity. Several published studies have shown that violacein induces apoptosis, but the mechanism for this has remained unclear. Using a genomic chemical profile in yeasts, we have identified direct targets of violacein: chaperones Hsp70. The present work aims to elucidate the cellular effects of the inhibiti…
Violacein is a natural compound with antibacterial, antiparasitic and antitumoral activities. Several published studies show evidence that violacein induces apoptosis, however the mechanism involved in it is still unknown. Using chemical genomic profiling in yeast, we identified direct targets of violacein: Hsp70 chaperones. The present work aims to elucidate cellular effects of Hsp70 cha…
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs through the blood-brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as host for expressing human blood-brain barrier transmembrane proteins. We will construct yeast strains where the na…
(Only some records are available in English at this moment)
The drug development for diseases that affect the Central Nervous System (CNS) should consider the transport of the compound through the human Blood Brain Barrier (BBB). Due to the protective function of this barrier, the entrance of xenobiotic molecules is restricted and occurs preferentially via membrane carriers present in the BBB cells. Hence, the development of methodologies for the …
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 14 | All research grants and scholarships |
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