CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Has a PhD in Cell and Molecular Biology - Göteborg University , Sweden (2004 ) and post- doctorate in Biochemistry at the University of Cambridge ( United Kingdom - 2004 to 2015 ) . Is currently assistant professor in the Department of Structural and Functional Biology (Cell Biology area) Institute of Biology , State University of Campinas (UNICAMP). Has experience in genetics and biochemistry with emphasis on synthetic biology. Uses Saccharomyces cerevisiae as a platform for the discovery of new drugs. This includes the genetic engineering of various metabolic pathways of the yeast for screenings on a large scale . Develops modulators of heterologous metabolic pathways in yeast works on the identification of new compounds with antiparasitic activity, performs chemical-genomic profiling for the indentification of mode of action of natural compounds with antiviral, antibacterial or antiparasitic activity, and works on the identification of cellular drug import mechanisms. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Antimicrobial used in toiletries could become option against malaria |
| Antimicrobial used in toiletries could become option against malaria |
The evolution of drug resistant malaria parasites coupled with the scarcity of new drugs, urge for discovery of new antimalarials. However, developing a brand new drug is a lengthy and costly process, due to bottlenecks in both the discovery and the therapeutic development (clinical trials) phases. Drug repositioning, which is the application of known and approved drugs and compounds to...
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs though the blood brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as a platform for studying the transport of chemicals into and out of cells. We will construct yeast strains with de...
Violacein is a natural compound with antibacterial, antiparasitic and antitumoral activities. Several published studies show evidence that violacein induces apoptosis, however the mechanism involved in it is still unknown. Using chemical genomic profiling in yeast, we identified direct targets of violacein: Hsp70 chaperones. The present work aims to elucidate cellular effects of Hsp70 c...
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs through the blood-brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as host for expressing human blood-brain barrier transmembrane proteins. We will construct yeast strains where the ...
Drugs targeting the central nervous system often fail clinical trials because of their poor transport to the brain. Therefore, our group is interested in unraveling the mechanisms of import of compounds through plasma membrane transporters of the blood-brain barrier. Using genetically modified Saccharomyces cerevisiae as a biological platform, recent studies have shown that it is possib...
(Only some records are available in English at this moment)
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs through the blood-brain barrier. In this project, we aim to use the yeast Saccharomyces cerevisiae as host for expressing human blood-brain barrier transmembrane proteins. We will construct yeast strains where the ...
Drugs are usually designed on the assumption that they enter cells by passive diffusion through the plasma membrane. However, there is increasing evidence that the transmembrane transport of xenobiotics by passive diffusion is the exception and not the rule. In this project, I will use Saccharomyces cerevisiae yeast as a platform to study the transport of chemicals into and out of cells...
Drugs directed to the central nervous system frequently fail in clinical trials because of their poor transport into the brain. This is due to the inefficient import of drugs though the blood brain barrier.In this project, we aim to use the yeast Saccharomyces cerevisiae as a platform for studying the transport of chemicals into and out of cells. To that end the scientific initiation st...
(Only some records are available in English at this moment)
The drug development for diseases that affect the Central Nervous System (CNS) should consider the transport of the compound through the human Blood Brain Barrier (BBB). Due to the protective function of this barrier, the entrance of xenobiotic molecules is restricted and occurs preferentially via membrane carriers present in the BBB cells. Hence, the development of methodologies for th...
| 2 / 2 | Ongoing research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 4 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 4 |
| Citations | 16 |
| Cit./Article | 4.0 |
| Data from Web of Science | |
BILSLAND, ELIZABETH; TAVELLA, TATYANA A.; KROGH, RENATA; STOKES, JAMIE E.; ROBERTS, ANNABELLE; AJIOKA, JAMES; SPRING, DAVID R.; ANDRICOPULO, ADRIANO D.; COSTA, FABIO T. M.; OLIVER, STEPHEN G.. Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons. BMC Biotechnology, v. 18, APR 11 2018. Web of Science Citations: 2. (15/03553-6, 12/16525-2)
FERREIRA, LETICIA T.; VENANCIO, VINICIUS P.; KAWANO, TAILA; ABRAO, LAILAH C. C.; TAVELLA, TATYANA A.; ALMEIDA, LUDIMILA D.; PIRES, GABRIEL S.; BILSLAND, ELIZABETH; SUNNERHAGEN, PER; AZEVEDO, LUCIANA; et al. Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Acai (Euterpe oleracea Mart.) Polyphenols. ACS OMEGA, v. 4, n. 13, p. 15628-15635, SEP 24 2019. Web of Science Citations: 0. (15/03553-6, 17/01986-8, 17/18611-7, 17/50400-6, 18/07007-4)
BILSLAND, ELIZABETH; VAN VLIET, LIISA; WILLIAMS, KEVIN; FELTHAM, JACK; CARRASCO, MARTA P.; FOTORAN, WESLEY L.; CUBILLOS, ELIANA F. G.; WUNDERLICH, GERHARD; GROTLI, MORTEN; HOLLFELDER, FLORIAN; et al. Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan. SCIENTIFIC REPORTS, v. 8, JAN 18 2018. Web of Science Citations: 6. (15/03553-6, 12/23306-5, 15/19103-0)
BILSLAND, ELIZABETH; BEAN, DANIEL M.; DEVANEY, EILEEN; OLIVER, STEPHEN G.. Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi. PLoS Neglected Tropical Diseases, v. 10, n. 1, JAN 2016. Web of Science Citations: 8. (15/19103-0)