CV Lattes
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Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Senior Professor at Psychology department of Faculty of Philosophy Sciences and Letters of Ribeirão Preto (FFCLRP) and of Graduation Program in Neurology and Neuroscience in the Faculty of Medicine of Ribeirão Preto (FMRP), University of São Paulo (USP). Graduated in Biological Sciences from Universidade de São Paulo (USP), Master at Pharmacology from Universidade de São Paulo and PhD at Physiology from Universidade de São Paulo. Post Graduation in Wake Forest University, USA (1990-1991) and Universitaet Tuebingen, Alemanha (1992-1995). She was Professor (1985-1990) in the Universidade Federal de Santa Catarina and in the Faculdade de Odontologia de Ribeirão Preto da USP (1999-2020). She was member of undergraduation SBFIS commission (2010-2019) and of Teaching Comission of APS (2015-2018) and recently was nominated (2018) member of the Board General Assembly of International Union of Physiological Sciences (IUPS) where is co-chair of the Education Commitee since 2015. She is also Secretary of Neuroscience Institute in Ribeirão Preto since 2016 when started to work with . scientific dissemination As a scientific researcher got several CNPq and FAPESP grants and gave several national and international lectures in Germany, France, Chile, USA, Germany, Japan, China and New Zealand.Has organized national and international events in physiology teaching and neuroscience and published text and articles in education. As researcher has experience in Neurosciences in the Pharmacology, Physiology and Experimental Odontology working more recently with neuroimmunoendocrine and behaviour alterations during inflammatory process and neurodegenerative. Guest Editor of the Journal of Neuroendocrinology, hold several awards, one in the CNPq /Renama, Academic Production category. For contact mjrocha@forp.usp.brf (Source: Lattes Curriculum)
Sepsis, a systemic inflammation triggered by an infectious agent, produces an inflammatory state in the central nervous system (CNS) that leads to autonomic, endocrine and cognitive-behavioral dysfunctions observed in clinical and experimental studies. Previous findings from this laboratory suggest that oxidative stress, microglial activation, synaptic dysfunction and eventually apoptosis…
Sepsis and its consequences, septic shock and organ dysfunction, pose a serious public health problem. Besides the high costs, cause great mortality and the survivors after hospital discharge may have cognitive impairments resulting in future admissions burdening even more the national health system. During sepsis are released cytokines, prostaglandins, leukotrienes, nitric oxide, etc., w…
(Only some records are available in English at this moment)
The installation of an inflammatory process in the CNS, even in the absence of in situ infection, is commonly referred to as sepsis-associated encephalopathy (SAE). This condition is responsible for brain dysfunction that will result in functional and cognitive impairment in sepsis surviving patients. Although the cognitive disabilities found in sepsis survivors should not be equated with…
Peripheral inflammatory mediators that reach the Central Nervous System (CNS) trigger the activation of microglial cells resulting in neuroinflammation. This inflammatory response may cause changes in the permeability of the blood-brain barrier (BBB), which with other alterations may lead to brain dysfunction causing the appearance of long-term neurological sequelae. Studies have shown th…
Despite technological advances, sepsis and its consequence severe sepsis and septic shock are still the leading cause of death in Intensive Care Unit (ICU). The majority of the survivors of these clinical conditions will present some cognitive impairment soon after discharge which can be or not over the years. Clinical and experimental studies, report that the initial phase of sepsis is c…
(Only some records are available in English at this moment)
Sepsis, a systemic inflammatory condition triggered by an infectious agent, induces an inflammatory status in central nervous system (CSN) which leads to autonomic, cognitive and behavioral alterations. The paraventricular nucleus of the hypothalamus (PVN) plays a major role in endocrine control during sepsis and is associated to the regulation of neurohypophyseal hormones and HPA axis. O…
Sepsis is a potentially fatal condition that occurs when the body produces an inflammatory response to an infectious agent (bacteria, fungi, parasites or viruses) that can lead to multiple organ failure, shock and death. In the pathophysiological process of sepsis excessive production and release of inflammatory mediators may directly or indirectly activate the central nervous system. In …
| 12 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 44 / 15 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 60 / 27 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 82 |
| Cit./Article | 6.8 |
| Data from Web of Science | |
SANTOS-JUNIOR, N. N.; CATALAO, C. H. R.; COSTA, L. H. A.; ROSSIGNOLLI, B. B.; DOS-SANTOS, R. C.; MALVAR, D. C.; MECAWI, A. S.; ROCHA, M. J. A.. Alterations in hypothalamic synaptophysin and death markers may be associated with vasopressin impairment in sepsis survivor rats. Journal of Neuroendocrinology, v. 30, n. 8, SI, AUG 2018. Web of Science Citations: 2. (15/12152-5)
DA SILVA, LETYCIA SILVANO; ROCHA CATALAO, CARLOS HENRIQUE; FELIPPOTTI, TATIANA TOCCHINI; DE OLIVEIRA-PELEGRIN, GABRIELA RAVANELLI; PETENUSCI, SERGIO; PEDRO DE FREITAS, LUIS ALEXANDRE; ALVES ROCHA, MARIA JOSE. Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. Pharmaceutical Biology, v. 55, n. 1, p. 269-276, 2017. Web of Science Citations: 10. (11/14711-0)
ANGENENDT DA COSTA, LUIS HENRIQUE; DOS SANTOS JUNIOR, NILTON NASCIMENTO; ROCHA CATALAO, CARLOS HENRIQUE; SHARSHAR, TAREK; CHRETIEN, FABRICE; ALVES DA ROCHA, MARIA JOSE. Vasopressin Impairment During Sepsis Is Associated with Hypothalamic Intrinsic Apoptotic Pathway and Microglial Activation. Molecular Neurobiology, v. 54, n. 7, p. 5526-5533, SEP 2017. Web of Science Citations: 4. (12/22246-9, 13/03723-3)
VULCZAK, ANDERSON; ROCHA CATALAO, CARLOS HENRIQUE; PEDRO DE FREITAS, LUIZ ALEXANDRE; ALVES ROCHA, MARIA JOSE. HSP-Target of Therapeutic Agents in Sepsis Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 17, SEP 1 2019. Web of Science Citations: 0. (18/02854-0)
OLIVEIRA-PELEGRIN, GABRIELA RAVANELLI; DE AZEVEDO, SERGIO VICENTE; YAO, SONG TIENG; MURPHY, DAVID; ALVES ROCHA, MARIA JOSE. Central NOS inhibition differentially affects vasopressin gene expression in hypothalamic nuclei in septic rats. Journal of Neuroimmunology, v. 227, n. 1-2, p. 80-86, OCT 8 2010. Web of Science Citations: 14. (07/08532-0)
STABILE, A. C.; STUANI, M. B. S.; LEITE-PANISSI, C. R. A.; ROCHA, M. J. A.. Effects of short-term acetaminophen and celecoxib treatment on orthodontic tooth movement and neuronal activation in rat. Brain Research Bulletin, v. 79, n. 6, p. 396-401, AUG 14 2009. Web of Science Citations: 9. (09/02468-4)
DA COSTA, LUIS HENRIQUE ANGENENDT; SANTOS-JUNIOR, NILTON NASCIMENTO; CATALAO, CARLOS HENRIQUE ROCHA; ROCHA, MARIA JOSE ALVES. Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis. Molecular Neurobiology, JAN 2021. Web of Science Citations: 0. (16/07803-0, 18/02854-0)
BIAGIONI, AUDREY FRANCISCO; DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FISHER, ISAAC RENE; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; FELIPPOTTI, TATIANA TOCCHINI; COIMBRA, NORBERTO CYSNE. Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test. Behavioural Brain Research, v. 298, n. B, p. 65-77, FEB 1 2016. Web of Science Citations: 15. (11/05821-7, 14/10742-7, 07/01174-1, 09/17258-5, 08/08955-1, 11/06036-1, 12/03798-0, 13/10984-8)
JOVILIANO‚ P.; JUNQUEIRA‚ AA; STABILE‚ AC; LEITE-PANISSI‚ CRA; ROCHA‚ MJA. Rapid maxillary expansion causes neuronal activation in brain structures of rats. Brain Research Bulletin, v. 76, n. 4, p. 396-401, 2008.
OLIVEIRA-PELEGRIN, G. R.; BRANCO, L. G. S.; ROCHA, M. J. A.. Central NO-cGMP pathway in thermoregulation and survival rate during polymicrobial sepsis. Canadian Journal of Physiology and Pharmacology, v. 88, n. 2, SI, p. 113-120, FEB 2010. Web of Science Citations: 1. (07/08532-0)
OLIVEIRA-PELEGRIN, GABRIELA RAVANELLI; AGUILA, FABIO ALVES; BASSO, PAULO JOSE; ALVES ROCHA, MARIA JOSE. Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis. Peptides, v. 31, n. 10, p. 1847-1852, OCT 2010. Web of Science Citations: 19. (07/08532-0)
PASCOTI BRUHN, FERNANDO HENRIQUE; FARIAS CORREA, POLLYANNA BARBOSA; OLIVEIRA-PELEGRIN, GABRIELA RAVANELLI; ALVES ROCHA, MARIA JOSE. Blocking systemic nitric oxide production alters neuronal activation in brain structures involved in cardiovascular regulation during polymicrobial sepsis. Neuroscience Letters, v. 453, n. 3, p. 141-146, APR 10 2009. Web of Science Citations: 8. (07/08532-0)
DA COSTA, LUIS HENRIQUE ANGENENDT. Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration. NEUROTOXICITY RESEARCH, JUN 2020. Web of Science Citations: 0. (18/10089-2, 18/02854-0, 17/12462-0)